44 research outputs found
<Abstract of published report>Variable glyceryl dinitrate formation as a function of glutathione S-transferase.
<Abstract of published report>Inhibition of purified human sucrase and isomaltase by ethanolamine derivatives.
<Abstract of Published Report>Expression of Sucrase and Intestinal-type Alkaline Phosphatase in Colorectal Carcinomas in Rats Treated with Methylazoxymethanol Acetate.
<Abstract of Published Report>Decreases of Metallothionein and Aminopeptidase N in Rental Cancer Tissues.
Undifferentiated Sarcoma of the Salivary Gland in a Mongolian Gerbil (Meriones unguiculatus)
A subcutaneous mass was found in the lower ventral neck region of a 55-week-old male
Mongolian gerbil (Meriones unguiculatus). Histopathologically, the mass
involved salivary glands and featured diffuse proliferation of pleomorphic neoplastic
cells with large necrotic foci. The lesion was well demarcated from the surrounding
tissue, although invasive growth to fibrous septa was occasionally observed. The
neoplastic cells were mainly arranged in irregular sheets with severe cellular atypia,
round to oval nuclei and varying amounts of eosinophilic cytoplasm. Mitotic figures and
multinucleated giant cells were frequent. Immunohistochemical analysis revealed that the
neoplastic cells were strongly positive for vimentin and S-100 and negative for NSE,
cytokeratin, α-SMA, c-kit, factor VIII, CD34, α-1-antitrypsin, lysozyme and MSR-A. Based
on the results, the mass was diagnosed as an undifferentiated sarcoma of the salivary
gland. To the best of our knowledge, this is the first report of such a tumor in Mongolian
gerbils
<Abstract of Published Report>Aminopeptidase N Regulated by Zinc in Human Prostate Participates in Tumor Cell Invasion.
<Abstract of Published Report>Hydrolytic Profile for Ester- or Amide-linkage by Carboxylesterases pI 5.3 and 4.5 from Human Liver.
<Abstract of published report>Gastric tumorigenicity of 1,2-dimethylhydrazine on the background of gastric intestinal metaplasia induced by X-irradiation in CD (SD) rats.
Gastric-and-Intestinal Mixed Intestinal Metaplasia Is Irreversible Point with Eradication of Helicobacter pylori
Abstract Helicobacter pylori (H. pylori) represents an important factor in the development of atrophic gastritis, intestinal metaplasia (IM), and gastric cancer. Eradication of H. pylori has been reported to prevent gastric cancer only in cases without atrophy or IM. However, histological changes with eradication have yet to be fully clarified. We evaluated 38 H. pylori-positive cases before and after eradication at the gland level; pyloric glands were classified as showing gastric proper (G) and IM gland types, with the latter including gastric-and-intestinal mixed IM (GI-IM) and solely intestinal IM (I-IM), depending on the remaining gastric phenotypes. On eradication, acute and chronic inflammation attenuated rapidly and gradually, respectively, whereas levels of MUC5AC and MUC6 expression were not markedly altered. Gland width, size of nuclei and cytoplasm and their ratio in surface foveolar epithelium, the number of Ki-67-positive cells and the length of the proliferating zone in each gland were significantly decreased in G glands after eradication compared with those in GI-IM and I-IM. The number of mitotic phase cells, positive for phosphorylated histone H3 at serine 28, was increased in both types of IM compared to that in G glands in the H. pylori-infected state, but unexpectedly remained unchanged with eradication. These results suggest that GI-IM, as the beginning of IM, could represent a histological irreversible point with eradication and be considered as a "histological point of no return"