Effects of GIMP Retinex Filtering Evaluated by the Image Entropy

A GIMP Retinex filtering can be used for enhancing images, with good results on foggy images, as recently discussed. Since this filter has some parameters that can be adjusted to optimize the output image, several approaches can be decided according to desired results. Here, as a criterion for optimizing the filtering parameters, we consider the maximization of the image entropy. We use, besides the Shannon entropy, also a generalized entropy.Comment: Keywords: Image Processing, Foggy Images, Retinex, Shannon Entropy, Generalized Entropies, Kaniadakis Entrop

A tour about Isaac Newton's life

Here we propose a tour about the life of Isaac Newton, using a georeferenced method, based on the free satellite maps. Our tour is modelled on the time-line of the great scientist's life, as an ancient "itinerarium" was modelled on the Roman roads, providing a listing of places and intervening distances, sometimes with short description or symbols concerning the places. KML language and Google Earth, with its Street View and 3D images are powerful tools to create this virtual tour.Comment: Georeferencing, Satellite Maps, KML, XML, Acme Mapper, History of Physic

Using Google Ngram Viewer for Scientific Referencing and History of Science

Today, several universal digital libraries exist such as Google Books, Project Gutenberg, Internet Archive libraries, which possess texts from general collections, and many other archives are available, concerning more specific subjects. On the digitalized texts available from these libraries, we can perform several analyses, from those typically used for time-series to those of network theory. For what concerns time-series, an interesting tool provided by Google Books exists, which can help us in bibliographical and reference researches. This tool is the Ngram Viewer, based on yearly count of n-grams. As we will show in this paper, although it seems suitable just for literary works, it can be useful for scientific researches, not only for history of science, but also for acquiring references often unknown to researchers.Comment: Keywords: Computers and Society, Literary works, Time-series, Referencin

Effects of GIMP Retinex Filtering Evaluated by the Image Entropy

A GIMP Retinex filtering can be used for enhancing images, with good results on foggy images, as recently discussed. Since this filter has some parameters that can be adjusted to optimize the output image, several approaches can be decided according to desired results. Here, as a criterion for optimizing the filtering parameters, we consider the maximization of the image entropy. We use, besides the Shannon entropy, also a generalized entropy

Using Google Ngram Viewer for Scientific Referencing and History of Science

Today, several universal digital libraries exist such as Google Books, Project Gutenberg, Internet Archive libraries, which possess texts from general collections, and many other archives are available, concerning more specific subjects. On the digitalized texts available from these libraries, we can perform several analyses, from those typically used for time-series to those of network theory. For what concerns time-series, an interesting tool provided by Google Books exists, which can help us in bibliographical and reference researches. This tool is the Ngram Viewer, based on yearly count of n-grams. As we will show in this paper, although it seems suitable just for literary works, it can be useful for scientific researches, not only for history of science, but also for acquiring references often unknown to researchers

The adherent/invasive escherichia coli (AIEC) strain LF82 invades and persists in human prostate cell lineRWPE-1 activating a strong inflammatory response

Adherent/invasive Escherichia coli (AIEC) strains have recently been receiving increased attention because they are more prevalent and persistent in the intestine of Crohn's disease (CD) patients than in healthy subjects. Since AIEC strains show a high percentage of similarity to extraintestinal pathogenic E. coli (ExPEC), neonatal meningitis-associated E. coli (NMEC), and uropathogenic E. coli (UPEC) strains, here we compared AIEC strain LF82 with a UPEC isolate (strain EC73) to assess whether LF82 would be able to infect prostate cells as an extraintestinal target. The virulence phenotypes of both strains were determined by using the RWPE-1 prostate cell line. The results obtained indicated that LF82 and EC73 are able to adhere to, invade, and survive within prostate epithelial cells. Invasion was confirmed by immunofluorescence and electron microscopy. Moreover, cytochalasin D and colchicine strongly inhibited bacterial uptake of both strains, indicating the involvement of actin microfilaments and microtubules in host cell invasion. Moreover, both strains belong to phylogenetic group B2 and are strong biofilm producers. In silico analysis reveals that LF82 shares with UPEC strains several virulence factors: namely, type 1 pili, the group II capsule, the vacuolating autotransporter toxin, four iron uptake systems, and the pathogenic island (PAI). Furthermore, compared to EC73, LF82 induces in RWPE-1 cells a marked increase of phosphorylation of mitogen-activated protein kinases (MAPKs) and of NF-κB already by 5 min postinfection, thus inducing a strong inflammatory response. Our in vitro data support the hypothesis that AIEC strains might play a role in prostatitis, and, by exploiting host-cell signaling pathways controlling the innate immune response, likely facilitate bacterial multiplication and dissemination within the male genitourinary trac

Nanoemulsions of Satureja montana essential oil. Antimicrobial and antibiofilm activity against avian Escherichia coli strains

Satureja montana essential oil (SEO) presents a wide range of biological activities due to its high content of active phytochemicals. In order to improve the essential oil’s (EO) properties, oil in water nanoemulsions (NEs) composed of SEO and Tween-80 were prepared, characterized, and their antimicrobial and antibiofilm properties assayed against Escherichia coli strains isolated from healthy chicken. Since surfactant and oil composition can strongly influence NE features and their application field, a ternary phase diagram was constructed and evaluated to select a suitable sur-factant/oil/water ratio. Minimal inhibitory concentration and minimal bactericidal concentration of NEs, evaluated by the microdilution method, showed that the SEO NE formulation exhibited higher inhibitory effects against planktonic E. coli than SEO alone. The quantification of biofilm production in the presence of NEs, assessed by crystal violet staining and scanning electron microscopy, evi-denced that sub-MIC concentrations of SEO NEs enable an efficient reduction of biofilm production by the strong producer strains. The optimized nanoemulsion formulation could ensure food safety quality, and counteract the antibiotic resistance of poultry associated E. coli, if applied/aerosolized in poultry farms

Oral bacteriotherapy in patients with COVID-19: a retrospective cohort study

Background: Mounting evidence suggests SARS-CoV-2 may impact on host microbiota and gut inflammation, infecting intestinal epithelial cells. This possible link and its implications can be investigated by observing the effects of modulation of the microbial flora in patients with COVID-19. The aim of this study was to compare the rate of mortality, the need of ICU hospitalization and the length of hospitalization in patients with severe COVID-19 pneumonia who received the best available therapy (BAT) vs. patients treated with BAT and supplemented with oral bacteriotherapy. Methods: This retrospective, observational cohort study included 200 adults with severe COVID-19 pneumonia. All patients received therapeutic regimens including low molecular weight heparin plus one or more between hydroxychloroquine, azithromycin, antivirals, and Tocilizumab. Oral bacteriotherapy was used as complementary treatment. Results: Out of the 200 patients, 112 received BAT without oral bacteriotherapy, and 88 BAT with oral bacteriotherapy. Crude mortality was 22%. Eleven percent died in the group of patients treated with BAT plus oral bacteriotherapy vs. 30% subjects in the group of patients managed only with BAT (p < 0.001). By multivariate analysis, the age >65 years, CRP >41.8 mg/L, Platelets <150.000 mmc, and cardiovascular events were associated with the increased risk of mortality. Oral bacteriotherapy was an independent variable associated with a reduced risk for death. Despite large prospective trials are needed, this study highlights a possible role for oral bacteriotherapy in the management of patients hospitalized for COVID-19 pneumonia

Diet supplementation, probiotics, and nutraceuticals in SARS-CoV-2 infection. A scoping review

The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) global pandemic is a devastating event that is causing thousands of victims every day around the world. One of the main reasons of the great impact of coronavirus disease 2019 (COVID-19) on society is its unexpected spread, which has not allowed an adequate preparation. The scientific community is fighting against time for the production of a vaccine, but it is difficult to place a safe and effective product on the market as fast as the virus is spreading. Similarly, for drugs that can directly interfere with viral pathways, their production times are long, despite the great efforts made. For these reasons, we analyzed the possible role of non-pharmacological substances such as supplements, probiotics, and nutraceuticals in reducing the risk of Sars-CoV-2 infection or mitigating the symptoms of COVID-19. These substances could have numerous advantages in the current circumstances, are generally easily available, and have negligible side effects if administered at the already used and tested dosages. Large scientific evidence supports the benefits that some bacterial and molecular products may exert on the immune response to respiratory viruses. These could also have a regulatory role in systemic inflammation or endothelial damage, which are two crucial aspects of COVID-19. However, there are no specific data available, and rigorous clinical trials should be conducted to confirm the putative benefits of diet supplementation, probiotics, and nutraceuticals in the current pandemic