849 research outputs found
Integration of the VIMOS Control System
The VIRMOS consortium of French and Italian Institutes (PI: O. Le Fevre, co-PI: G. Vettolani) is manufacturing two wide field imaging multi-object spectrographs for the European Southern Observatory Very Large Telescope (VLT), with emphasis on the ability to carry over spectroscopic surveys of large numbers of sources: the VIsible Multi-Object Spectrograph, VIMOS, and the Near InfraRed Multi-Object Spectrograph, NIRMOS. There are 52 motors to be controlled in parallel in the spectrograph, making VIMOS a complex machine to be handled. This paper will focus on the description of the control system, designed in the ESO VLT standard control concepts, and on some integration issues and problem solving strategies...
A compact ultranarrow high-power laser system for experiments with 578nm Ytterbium clock transition
In this paper we present the realization of a compact, high-power laser
system able to excite the Ytterbium clock transition at 578 nm. Starting from
an external-cavity laser based on a quantum dot chip at 1156 nm with an
intra-cavity electro-optic modulator, we were able to obtain up to 60 mW of
visible light at 578 nm via frequency doubling. The laser is locked with a 500
kHz bandwidth to a ultra-low-expansion glass cavity stabilized at its zero
coefficient of thermal expansion temperature through an original thermal
insulation and correction system. This laser allowed the observation of the
clock transition in fermionic Yb with a < 50 Hz linewidth over 5
minutes, limited only by a residual frequency drift of some 0.1 Hz/s
The VST Telescope Control Software in the ESO VLT Environment
The VST (VLT Survey Telescope) is a 2.6 m Alt-Az telescope to be installed at Mount Paranal in Chile, in the European Southern Observatory (ESO) site. The VST is a wide-field imaging facility planned to supply databases for the ESO Very Large Telescope (VLT) science and carry out stand-alone observations in the UV to I spectral range. This paper will focus mainly on control software aspects, describing the VST software architecture in the context of the whole ESO VLT control concept. The general architecture and the main components of the control software will be described...
Neurophysiological Profile of Antismoking Campaigns
Over the past few decades, antismoking public service announcements (PSAs) have been used by governments to promote healthy
behaviours in citizens, for instance, against drinking before the drive and against smoke. Effectiveness of such PSAs has been
suggested especially for young persons. By now, PSAs efficacy is still mainly assessed through traditional methods (questionnaires
and metrics) and could be performed only after the PSAs broadcasting, leading to waste of economic resources and time in the
case of Ineffective PSAs. One possible countermeasure to such ineffective use of PSAs could be promoted by the evaluation of the
cerebral reaction to the PSA of particular segments of population (e.g., old, young, and heavy smokers). In addition, it is crucial to
gather such cerebral activity in front of PSAs that have been assessed to be effective against smoke (Effective PSAs), comparing
results to the cerebral reactions to PSAs that have been certified to be not effective (Ineffective PSAs). &e eventual differences
between the cerebral responses toward the two PSA groups will provide crucial information about the possible outcome of new
PSAs before to its broadcasting. &is study focused on adult population, by investigating the cerebral reaction to the vision of
different PSA images, which have already been shown to be Effective and Ineffective for the promotion of an antismoking
behaviour. Results showed how variables as gender and smoking habits can influence the perception of PSA images, and how
different communication styles of the antismoking campaigns could facilitate the comprehension of PSA’s message and then
enhance the related impac
Antismoking campaigns’ perception and gender differences: a comparison among EEG Indices
Human factors’ aim is to understand and evaluate the interactions between people and tasks, technologies, and environment. Among human factors, it is possible then to include the subjective reaction to external stimuli, due to individual’s characteristics and states of mind. These processes are also involved in the perception of antismoking public service announcements (PSAs), the main tool for governments to contrast the first cause of preventable deaths in the world: tobacco addiction. In the light of that, in the present article, it has been investigated through the comparison of different electroencephalographic (EEG) indices a typical item known to be able of influencing PSA perception, that is gender. In order to investigate the neurophysiological underpinnings of such different perception, we tested two PSAs: one with a female character and one with a male character. Furthermore, the experimental sample was divided into men and women, as well as smokers and nonsmokers. The employed EEG indices were the mental engagement (ME: the ratio between beta activity and the sum of alpha and theta activity); the approach/withdrawal (AW: the frontal alpha asymmetry in the alpha band); and the frontal theta activity and the spectral asymmetry index (SASI: the ratio between beta minus theta and beta plus theta). Results suggested that the ME and the AW presented an opposite trend, with smokers showing higher ME and lower AW than nonsmokers. The ME and the frontal theta also evidenced a statistically significant interaction between the kind of the PSA and the gender of the observers; specifically, women showed higher ME and frontal theta activity for the male character PSA. This study then supports the usefulness of the ME and frontal theta for purposes of PSAs targeting on the basis of gender issues and of the ME and the AW and for purposes of PSAs targeting on the basis of smoking habits
Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent
A recombinant MnSOD (rMnSOD) synthesized by specific cDNA clones derived from a liposarcoma cell line was shown to have the same sequence as the wild-type MnSOD expressed in the human myeloid leukaemia cell line U937, except for the presence of the leader peptide at the N-terminus. These results were fully confirmed by the molecular mass of rMnSOD as evaluated by ES/MS analysis (26662.7 Da) and the nucleotide sequence of the MnSOD cDNA. The role of the leader peptide in rMnSOD was investigated using a fluorescent and/or 68Gallium-labelled synthetic peptide. The labelled peptide permeated MCF-7 cells and uptake could be inhibited in the presence of an excess of oestrogen. In vivo it was taken up by the tumour, suggesting that the molecule can be used for both therapy and diagnosis. The in vitro and in vivo pharmacology tests confirmed that rMnSOD is only oncotoxic for tumour cells expressing oestrogen receptors. Pharmacokinetic studies in animals performed with 125I- and 131I-labelled proteins confirmed that, when administered systemically, rMnSOD selectively reached the tumour, where its presence was unambiguously demonstrated by scintigraphic and PET scans. PCR analysis revealed that Bax gene expression was increased and the Bcl2 gene was down regulated in MCF7 cells treated with rMnSOD, which suggests that the protein induces a pro-apoptotic mechanism
Using Old Laboratory Equipment with Modern Web-of-Things Standards: a Smart Laboratory with LabThings Retro
There has been an increasing, and welcome, Open Hardware trend towards
science teams building and sharing their designs for new instruments. These
devices, often built upon low-cost microprocessors and micro-controllers, can
be readily connected to enable complex, automated, and smart experiments. When
designed to use open communication web standards, devices from different
laboratories and manufacturers can be controlled using a single protocol, and
even communicate with each other. However, science labs still have a majority
of old, perfectly functional, equipment which tends to use older, and sometimes
proprietary, standards for communications. In order to encourage the continued
and integrated use of this equipment in modern automated experiments, we
develop and demonstrate LabThings Retro. This allows us to retrofit old
instruments to use modern web-of-things standards, which we demonstrate with
closed-loop feedback involving an optical microscope, digital imaging and fluid
pumping.Comment: Supplementary material - video demonstration available at
https://zenodo.org/doi/10.5281/zenodo.1012373
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