Polymorphisme Thréonine 312 Alanine de la chaîne Aa du fibrinogène (recherche d'une association avec l'embolie pulmonaire)

Le polymorphisme Thr312Ala du fibrinogène est situé dans la région carboxy-terminale de la chaîne Aa du fibrinogène. Il influence les propriétés structurales du caillot de fibrine et sa stabilité et pourrait lui donner une susceptibilité plus importante à la migration. Deux études cliniques effectuées par la même équipe : Carter et coll. semblent appuyer cette hypothèse. Le but de ce travail était de comparer la fréquence génotypique de ce polymorphisme chez les sujets ayant eu un accident de thrombose veineuse profonde proximale et/ou une d'embolie pulmonaire avec une population de patients de la même région géographique ayant présenté une thrombose distale. La comparaison statistique entre les groupes de patients en appliquant le test du chi2 n'a montré aucune association significative entre la présence du polymorphisme Aa Thr312Ala et la survenue d'embolie pulmonaireTOURS-BU Sciences Pharmacie (372612104) / SudocSudocFranceF

Evaluation of the capillary electrophoresis Capillarys II instrument for the analysis of hemoglobin

info:eu-repo/semantics/nonPublishe

Evaluation of the capillary electrophoresis Capillarys CDT method

info:eu-repo/semantics/nonPublishe

In vitro activity of temocillin against extended spectrum β-lactamase-producing Escherichia coli

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Emergence of CTX-M extended spectrum beta-lactamase-producing Escherichia coli in Belgium.

Journal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Fibrinogen Aalpha-Thr312Ala and factor XIII-A Val34Leu polymorphisms in idiopathic venous thromboembolism.

International audienceINTRODUCTION: Fibrinogen Aalpha-Thr312Ala and Factor XIII Val34Leu polymorphisms have been shown to modify fibrin clot structure and function. However, clinical studies have yielded conflicting results on their possible association with venous thromboembolism (VTE). METHODS: We studied the association between these two polymorphisms and VTE in a hospital-based case-control study. We also assessed whether an independent or interactive association exists between Aalpha-fibrinogen Thr312Ala and FXIII Val34Leu polymorphisms and VTE. Fibrinogen Aalpha-Thr312Ala and FXIII Val34Leu polymorphisms were determined after PCR and restriction endonuclease digestion in 286 patients with idiopathic VTE and 286 age- and gender-matched controls. Results were analysed using a conditional logistic regression model for matched series. RESULTS: The Fg-Aalpha 312Ala allele was associated with higher risk of VTE (OR 1.5; 95% CI: 1.1 to 2.2, p=0.01) while the FXIII 34Leu allele appeared protective (OR 0.7; 95% CI: 0.6 to 0.9, p=0.02). Both alleles demonstrated an independent association with idiopathic VTE after adjustment for Factor V Leiden and G20210A prothrombin polymorphisms. There was no interaction between the fibrinogen Aalpha-Thr312Ala and FXIII Val34Leu polymorphisms for the risk of VTE. CONCLUSION: In this case-control study, the fibrinogen Fg-Aalpha 312Ala allele was associated with an increased risk of VTE. The FXIII 34Leu allele was also significantly associated with a lower risk of VTE without any interaction between the two polymorphisms studied