Psychological interventions influence patients' attitudes and beliefs about their chronic pain.

Background: Patients' changing attitudes and beliefs about pain are considered as improvements in the treatment of chronic pain. Multidisciplinary approaches to pain allow modifications of coping strategies of patients, from passive to active. Methods: We investigate how two therapeutic treatments impact patients' attitudes and beliefs regarding pain, as measured with the Survey of Pain Attitudes (SOPA). We allocated 415 patients with chronic pain either to psychoeducation combined with physiotherapy, self-hypnosis combined with self-care learning, or to control groups. Pain intensity, global impression of change, and beliefs and attitudes regarding pain were assessed before and after treatment. Results: Our main results showed a significant effect of psychoeducation/physiotherapy on control, harm, and medical cure SOPA subscales; and a significant effect of self-hypnosis/self-care on control, disability and medical cure subscales. Correlation results showed that pain perception was negatively associated with control, while positively associated with disability, and a belief that hurt signifies harm. Patients' impression of improvement was associated with greater control, lower disability, and lower belief that hurt signifies harm. Conclusions: The present study showed that self-hypnosis/self-care and psychoeducation/physiotherapy were associated with patients' evolution of coping strategies from passive to active, allowing them to reduce pain perception and improve their global impression of treatment effectiveness. Keywords: Chronic pain, Hypnosis, Psychoeducation, Coping, Pain belief

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

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Hypnosis for pain management

peer reviewedThe purposes of this chapter are : - to provide a brief definition of hypnosis, hypnotic process and self-hypnosis. - to describe briefly the neurophysiological correlates of hypnosis and hypnotic analgesia. - to propose a short review of recent literature concerning the effectiveness of clinical hypnosis in chronic pain, emphasizing more specifically research on the effectiveness of hypnosis with migraine. - to address some questions about its daily clinical use

Comment aider les patients douloureux chroniques à mieux gérer leur problème de douleur ? Etude exploratoire de l'impact de l'apprentissage de l'autohypnose et de la psycho-éducation

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De la théorie au pragmatisme d'une conception postmoderne de la motivation dans l'éducation thérapeutique des patients douloureux chroniques

Ces dernières années, la littérature a démontré un intérêt croissant pour le concept de motivation dans l’éducation thérapeutique des patients souffrant de douleurs chroniques. Ainsi, de nombreux courants idéologiques ont abordé le concept de motivation mais aussi d’éducation thérapeutique tout en produisant de multiples théories et nouveaux savoirs, cloisonnés les uns des autres. Dans cet article, nous situons et contextualisons, dans un premier temps, les concepts de motivation et d’éducation thérapeutique des patients souffrant de douleurs chroniques et nous terminons, ensuite, par une réflexion sur l’importance d’utiliser ces concepts dans une visée postmoderne au sein de paradigmes. À ce titre, nous questionnons notre pratique clinique en proposant une lecture des concepts de motivation et d’éducation thérapeutique des patients atteints de douleurs chroniques au moyen du paradigme des 12 besoins de J.-P. Pourtois et H. Desmet.Recent research indicates a growing interest in motivation and therapeutic education of patients with chronic pain. Many ideological currents have thus developed much knowledge and new theories about motivation and therapeutic education. The purpose of the present work is to contextualize the concepts of motivation and therapeutic education of patients with chronic pain, and, finally to focus on the importance of using these concepts in a set of postmodern paradigms. Therefore, we questioned our clinical practice using the paradigm of J.-P. Pourto is and H. Desmet according to the 12 human needs

Drop-out from chronic pain treatment programmes: Is randomization justified in biopsychosocial approaches?

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Psychological Interventions Influence Patients’ Attitudes and Beliefs about their Chronic Pain: A 6-Month Follow-up

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