An efficient synthesis and spectroscopic characterization of Schiff bases containing 9,10-anthracenedione moiety

A new method has been developed for the synthesis of novel Schiff bases containg anthraquinone moiety using dodeca-Tungstosilicic acid/P2O5 under solvent free conditions at room temperature. The reaction was completed in 1-3 minutes with excellent yields. This method was found to be more efficient, easy and hazardous free for the synthesis of azomethines. The development of these type of methadologies in synthetic chemistry may contribute to green chemistry. The structures of synthesized novel Schiff bases was elucidated using 1H-NMR, 13C-NMR, LCMS, FTIR and CHN analysis

Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives

A series of 4-aryl methylidene-2-phenyl/methyl-5-(4H)-oxazolone derivatives (2-7) have been synthesized using the reported method by condensation of aldehydes with N-benzoyl / N-acetyl glycine in the presence of zinc oxide as a catalyst and acetic anhydride at room temperature in ethanol. The compounds (2-6) are new derivatives. The structures of compounds were evaluated on the basis of 1H-NMR, 13C-NMR, EIMS, FT-IR and elemental analysis. All the compounds were screened for their antibacterial and urease inhibition activity. Antibacterial activity was tested by agar well diffusion method using Mueller Hinton Agar medium. Compound (2) showed excellent activity against S. aureus which has 16 mm (80%) inhibition and above 24 mm (70%) against S. typhi. The most active compound against E. coli was compound (6) having 20 mm (80%) inhibition followed by compound (5) having above 18 mm (70%) inhibition. Urease inhibition activity of all the compounds was determined by indophenol method. Compounds (3, 6) and (7) showed significant inhibition against Jacks bean urease

{2-[(Benzo­yloxy)meth­yl]-1-oxo-3H-pyrrolizin-2-yl}methyl benzoate

The title compound, C23H19NO5, was prepared by esterification of 2,2-bis­(hy­droxy­meth­yl)-2,3-dihydro-1H-pyrrolizin-1-one with benzoyl chloride in pyridine·The pyrrolizine ring system is approximately planar with a maximum deviation of 0.008 (2) Å from the least-squares plane; the two phenyl rings are oriented at dihedral angles of 64.26 (11) and 70.75 (10)° with respect to the pyrrolizine ring system. Weak inter­molecular C—H⋯O hydrogen bonding occurs in the crystal structure

PHYSICO-CHEMICAL STUDIES OF INDIGENOUS DIURETIC MEDICINAL PLANTS

ABSTRACT Six indigenous medicinal plants have been selected for the physico-chemical studies. These plants belong to Graminaceae, cucubitaceae, cruciferae and Moringaceae families. Colour, taste, pH, density, viscosity, refractive index, specific gravity and optical rotation have been studied in hot water extract of Cymbopogon citratus (DC) stapf where moisture, ash content, acid insoluble matter, fiber content, oil content. Iodine value and Invert sugar studies have been carried out in ethanolic extracts of Citrullus vullgaris, Cucumis melo, Moringa oleifera, Raphanus sativus and Zea mays. Refractive index, specific gravity, saponification value, Iodine value, unsaponiflcable matter and Acid value, colour in lovibond cell have been studied in Raphanus seeds oil