The body constitution of patients and intubation scales as predictors of difficult intubation considered in relation to the experience of the intubator

The aims of the study were to identify factors that may result in difficulties in intubation, and to compare the results obtained when an experienced and when a less experienced anaesthesiologist was involved. The 96 patients included in the study were evaluated for difficult intubation according to the following scales: Mallampati, upper lip bite test (ULBT) and Patil. The mobility of the cervical segments of the vertebral column, the distance between the jugular notch of the sternum and the chin and the anatomical constitution of the body were other factors that were taken into consideration. Statistical analysis was performed in order to identify factors that may result in difficulties in intubation for an experienced and for a less experienced anaesthesiologist

The multi-stream flows and the dynamics of the cosmic web

A new numerical technique to identify the cosmic web is proposed. It is based on locating multi-stream flows, i.e. the places where the velocity field is multi-valued. The method is local in Eulerian space, simple and computaionally efficient. This technique uses the velocities of particles and thus takes into account the dynamical information. This is in contrast with the majority of standard methods that use the coordinates of particles only. Two quantities are computed in every mesh cell: the mean and variance of the velocity field. In the cells where the velocity is single-valued the variance must be equal to zero exactly, therefore the cells with non-zero variance are identified as multi-stream flows. The technique has been tested in a N-body simulation of the \L CDM model. The preliminary analysis has shown that numerical noise does not pose a significant problem. The web identified by the new method has been compared with the web identified by the standard technique using only the particle coordinates. The comparison has shown overall similarity of two webs as expected, however they by no means are identical. For example, the isocontours of the corresponding fields have significantly different shapes and some density peaks of similar heights exhibit significant differences in the velocity variance and vice versa. This suggest that the density and velocity variance have a significant degree of independence. The shape of the two-dimensional pdf of density and velocity variance confirms this proposition. Thus, we conclude that the dynamical information probed by this technique introduces an additional dimension into analysis of the web.Comment: 19 pages, 10 figure

The Fueling and Evolution of AGN: Internal and External Triggers

In this chapter, I review the fueling and evolution of active galactic nuclei (AGN) under the influence of internal and external triggers, namely intrinsic properties of host galaxies (morphological or Hubble type, color, presence of bars and other non-axisymmetric features, etc) and external factors such as environment and interactions. The most daunting challenge in fueling AGN is arguably the angular momentum problem as even matter located at a radius of a few hundred pc must lose more than 99.99 % of its specific angular momentum before it is fit for consumption by a BH. I review mass accretion rates, angular momentum requirements, the effectiveness of different fueling mechanisms, and the growth and mass density of black BHs at different epochs. I discuss connections between the nuclear and larger-scale properties of AGN, both locally and at intermediate redshifts, outlining some recent results from the GEMS and GOODS HST surveys.Comment: Invited Review Chapter to appear in LNP Volume on "AGN Physics on All Scales", Chapter 6, in press. 40 pages, 12 figures. Typo in Eq 5 correcte

The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic syndromes

Nonsynonymous TP53 exon 4 single-nucleotide polymorphism (SNP), R72P, is linked to cancer and mutagen susceptibility. R72P associations with specific cancer risk, particularly hematological malignancies, have been conflicting. Myelodysplastic syndrome (MDS) with chromosome 5q deletion is characterized by erythroid hypoplasia arising from lineage-specific p53 accumulation resulting from ribosomal insufficiency. We hypothesized that apoptotically diminished R72P C-allele may influence predisposition to del(5q) MDS. Bone marrow and blood DNA was sequenced from 705 MDS cases (333 del(5q), 372 non-del(5q)) and 157 controls. Genotype distribution did not significantly differ between del(5q) cases (12.6% CC, 38.1% CG, 49.2% GG), non-del(5q) cases (9.7% CC, 44.6% CG, 45.7% GG) and controls (7.6% CC, 37.6% CG, 54.8% GG) (P = 0.13). Allele frequency did not differ between non-del(5q) and del(5q) cases (P = 0.91) but trended towards increased C-allele frequency comparing non-del(5q) (P = 0.08) and del(5q) (P = 0.10) cases with controls. Median lenalidomide response duration increased proportionate to C-allele dosage in del(5q) patients (2.2 (CC), 1.3 (CG) and 0.89 years (GG)). Furthermore, C-allele homozygosity in del(5q) was associated with prolonged overall and progressionfree survival and non-terminal interstitial deletions that excluded 5q34, whereas G-allele homozygozity was associated with inferior outcome and terminal deletions involving 5q34 (P = 0.05). These findings comprise the largest MDS R72P SNP analysis

A Parallel Algorithm and Architecture for the Control of Kinematically Redundant Manipulators

Kinematically redundant manipulators are inherently capable of more dextrous manipulation due to their additional degrees of freedom. To achieve this dexterity, however, one must be able to efficiently calculate the most desirable configuration from the infinite number of possible configurations that satisfy the end-effector constraint. It has been previously shown that the singular value decomposition (SVD) plays a crucial role in doing such calculations. In this work, a parallel algorithm for calculating the SVD is incorporated into a computational scheme for solving the equations of motion for kinematically redundant systems. This algorithm, which generalizes the damped least squares formulation to include solutions that utilize null-space projections and task prioritization as well as augmented or extended Jacobians, is then implemented on a simple linear array of processing elements. By taking advantage of the error bounds on the perturbation of the SVD, it is shown that an array ..