107 research outputs found
Brain regions essential for improved lexical access in an aged aphasic patient: a case report
BACKGROUND: The relationship between functional recovery after brain injury and concomitant neuroplastic changes is emphasized in recent research. In the present study we aimed to delineate brain regions essential for language performance in aphasia using functional magnetic resonance imaging and acquisition in a temporal sparse sampling procedure, which allows monitoring of overt verbal responses during scanning. CASE PRESENTATION: An 80-year old patient with chronic aphasia (2 years post-onset) was investigated before and after intensive language training using an overt picture naming task. Differential brain activation in the right inferior frontal gyrus for correct word retrieval and errors was found. Improved language performance following therapy was mirrored by increased fronto-thalamic activation while stability in more general measures of attention/concentration and working memory was assured. Three healthy age-matched control subjects did not show behavioral changes or increased activation when tested repeatedly within the same 2-week time interval. CONCLUSION: The results bear significance in that the changes in brain activation reported can unequivocally be attributed to the short-term training program and a language domain-specific plasticity process. Moreover, it further challenges the claim of a limited recovery potential in chronic aphasia, even at very old age. Delineation of brain regions essential for performance on a single case basis might have major implications for treatment using transcranial magnetic stimulation
Transcranial brain stimulation (TMS and tDCS) for post-stroke aphasia rehabilitation: Controversies
Contribution to the evaluation of language disturbances in subcortical lesions: a piloty study
Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: implications for neurodegenerative diseases
Estimulação magnética transcraniana na neuropsicologia: novos horizontes em pesquisa sobre o cérebro
EinfluĂ von Lokalisation und GröĂe der LĂ€sion auf den Spontanverlauf und den Therapieerfolg bei Aphasien
- âŠ