Decreased vitamin B 12

Background: Oral isotretinoin treatment might influence the levels of vitamin B 12 and folic acid. Aims and Objectives: The aim of this study is to compare vitamin B 12 and folic acid levels in patients with moderate and severe acne vulgaris with those of the healthy control group and to investigate the effect of isotretinoin treatment on these vitamins. Materials and Methods: Patients who completed 6 months of isotretinoin therapy for moderate and severe forms of acne vulgaris and a control group consisting of healthy individuals between February 2011 and March 2012 were included in the study. Before isotretinoin therapy and at 6.- months of the therapy, serum vitamin B 12 and folic acid levels were measured. In the healthy control group, vitamin B 12 and folic acid levels were assessed only once. Results: In total, 120 patients with moderate and severe acne vulgaris who completed 6 months isotretinoin therapy and 100 healthy individuals who constituted the control group were included in the study. Pre-treatment vitamin B 12 values of the patient group were found to be statistically significantly higher (P = 0.002), but any statistically significant difference was not detected in folic acid measurements (P = 0.566). A statistically significant decrease was detected in post-treatment vitamin B 12 and folic acid levels (P < 0.05). Conclusion: Vitamin B 12 /folic acid treatment should be given under medical surveillance before and during isotretinoin therapy. Supplementation of these vitamins should be recommended in cases of their deficiency, so as to decrease the risks of neuropsychiatric and occlusive vascular diseases

Familial mediterranean fever: assessment of clinical manifestations, pregnancy, genetic mutational analyses, and disease severity in a national cohort

PMID = 3152223

Dielectric spectroscopy of AC aged polyethylene in the frequency range of 10-5 Hz to 106 Hz

NRC publication: Ye

Rosacea

Rosacea is an inflammatory, chronic-recurring dermatitis of the face. It is common in adult females with I\u2013II phototype. It is characterized clinically by the presence of one or more of the following features: flushing, erythema, telangiectasia, papules, pustules, and nodules. Ocular involvement can also occur. Etiopathogenetic role of Demodex folliculorum and Helicobacter pylori has not been confirmed. The National Rosacea Society Expert Committee divided the disease into four clinical varieties (rosacea characterized by flushing and erythema, with or without telangiectasia, papulopustular rosacea, phymatous rosacea, and ocular rosacea). According to Cochrane, topical metronidazole and azelaic acid as well as oral tetracyclines and metronidazole are effective in the treatment of rosacea. Literature data about the use of peelings are very poor. In some patients, salicylic acid, azelaic acid, and mandelic acid were used