Combined EEG-fMRI and tractography to visualise propagation of epileptic activity

In a patient with refractory temporal lobe epilepsy, EEG-fMRI showed activation in association with left anterior temporal interictal discharges, in the left temporal, parietal and occipital lobes. Dynamic causal modelling suggested propagation of neural activity from the temporal focus to the area of occipital activation. Tractography showed connections from the site of temporal lobe activation to the site of occipital activation. This demonstrates the principle of combining EEG-fMRI and tractography to delineate the pathways of propagation of epileptic activity

Recording of EEG during fMRI experiments: patient safety

The acquisition of electroencephalograms (EEG) during functional magnetic resonance imaging (fMRI) experiments raises important practical issues of patient safety. The presence of electrical wires connected to the patient in rapidly changing magnetic fields results in currents flowing through the patient due to induced electromotive forces (EMF), by three possible mechanisms: fixed loop in rapidly changing gradient fields; fixed loop in a RF electromagnetic field; moving loop in the static magnetic field. RF-induced EMFs were identified as the most important potential hazard. We calculated the minimum value of current-limiting resistance to be fitted in each EEG electrode lead for a representative worst case loop, and measured RF magnetic field intensity and heating in a specific type of current-limiting resistors. The results show that electrode resistance should be > or = 13 k(omega) for our setup. The methodology presented is general and can be useful for other centers

Wallerian degeneration in the optic radiation after temporal lobectomy demonstrated in vivo with diffusion tensor imaging

PURPOSE: Diffusion tensor imaging allows the quantitative assessment of the microstructural organization of tracts in vivo (MR tractography). We used the new technique of MR tractography to demonstrate the effects of temporal lobectomy on the optic radiation. METHODS: Spatially normalised maps encoding magnitude of the bias (anisotropy) of diffusion of three patients with temporal lobe resections were compared with spatially normalised diffusion maps of 22 control subjects. All three patients were operated on for the treatment of medically intractable temporal lobe epilepsy and had a normal neurologic examination before surgery. One patient had an amygdalocorticectomy. Two patients had standard en bloc resections, one of whom developed a homonymous hemianopia after surgery. RESULTS: In the patient with hemianopia, a significant reduction of diffusion anisotropy (greater than mean+/-2 SD) consistent with wallerian degeneration was demonstrated in the optic radiation on the side of the temporal lobectomy, extending from the temporal to the occipital lobe. In the other patient with standard en bloc resection but clinically no hemianopia, the optic radiation was only marginally affected. In the third patient (amygdalocorticectomy), the diffusion anisotropy was within the normal range in the expected position of the optic radiation. CONCLUSIONS: Our findings show that MR tractography may be a useful tool to demonstrate wallerian degeneration in the optic radiation after temporal lobectomy in patients with hemianopia. This is the first time that this new method has been applied in postoperative imaging; it enables us to visualise the morphologic correlate of dysfunctional pathways after epilepsy surgery in vivo. The potential for using MR tractography to study other aspects of epilepsy is discussed

Spin preparation sequences for echo-planar imaging

SIGLEAvailable from British Library Document Supply Centre- DSC:D176966 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Evaluation of temperature increase during Magnetic Resonance examinations by combining electromagnetic/thermal simulations and B1 maps

The purpose of the present study is to evaluate the temperature increase due to radio-frequency (RF) exposure in Magnetic Resonance (MR) examinations, by combining electromagnetic/thermal simulations and B1 maps