12 research outputs found
Outcomes of Adjuvant Radiation Therapy and Lymph Node Dissection in Pancreatic Cancer: A SEER Analysis
Favorable Perioperative and Survival Outcomes After Resection of Borderline Resectable Pancreatic Cancer Treated With Neoadjuvant Stereotactic Radiation and Chemotherapy Compared With Upfront Pancreatectomy for Resectable Cancer
Stereotactic Body Radiation Therapy (SBRT) for Borderline Resectable and Locally Advanced Pancreatic Cancer is Effective and Well Tolerated
Stereotactic Body Radiation Therapy for Locally Advanced and Borderline Resectable Pancreatic Cancer: Updated Outcomes and Toxicity in Over 100 Patients
Survival Benefits of Adjuvant Radiation Therapy and Lymph Node Dissection in Pancreatic Cancer Treated With Surgery and Chemotherapy
Predictors and Survival for Pathologic Tumor Response Grade in Borderline Resectable and Locally Advanced Pancreatic Cancer Treated With Induction Chemotherapy and Neoadjuvant Stereotactic Body Radiation Therapy
Outcomes of Adjuvant Radiation Therapy and Lymph Node Dissection in Elderly Pancreatic Cancer Patients Treated With Surgery and Chemotherapy
Does Metabolic Tumor Volume Predict Tumor Regression Grade After Neoadjuvant Therapy for Borderline Resectable Pancreatic Cancer?
Adenomatous polyposis coli (APC) regulates miR17-92 cluster through \u3b2-catenin pathway in colorectal cancer
Adenomatous polyposis coli (APC) mutation is the most common genetic change in sporadic colorectal cancer (CRC). Although deregulations of miRNAs have been frequently reported in this malignancy, APC-regulated miRNAs have not been extensively documented. Here, by using an APC-inducible cell line and array analysis, we identified a total of 26 deregulated miRNAs. Among them, members of miR-17-92 cluster were dramatically inhibited by APC and induced by enforced expression of \u3b2-catenin. Furthermore, we demonstrate that activated \u3b2-catenin resulted from APC loss binds to and activates the miR-17-92 promoter. Notably, enforced expression of miR-19a overrides APC tumor suppressor activity, and knockdown of miR-19a in cancer cells with compromised APC function reduced their aggressive features in vitro. Finally, we observed that expression of miR-19a significantly correlates with \u3b2-catenin levels in colorectal cancer specimens, and it is associated to the aggressive stage of tumor progression. Thus, our study reveals that miR-17-92 cluster is directly regulated by APC/\u3b2-catenin pathway and could be a potential therapeutic target in colon cancers with aberrant APC/\u3b2-catenin signaling.Oncogene advance online publication, 25 January 2016; doi:10.1038/onc.2015.522