7 research outputs found
Determinisitic Optical Fock State Generation
We present a scheme for the deterministic generation of N-photon Fock states
from N three-level atoms in a high-finesse optical cavity. The method applies
an external laser pulsethat generates an -photon output state while
adiabatically keeping the atom-cavity system within a subspace of optically
dark states. We present analytical estimates of the error due to amplitude
leakage from these dark states for general N, and compare it with explicit
results of numerical simulations for N \leq 5. The method is shown to provide a
robust source of N-photon states under a variety of experimental conditions and
is suitable for experimental implementation using a cloud of cold atoms
magnetically trapped in a cavity. The resulting N-photon states have potential
applications in fundamental studies of non-classical states and in quantum
information processing.Comment: 25 pages, 9 figure
Chemical Approaches to Inhibiting the Hepatitis B Virus Ribonuclease H
Hepatitis B virus (HBV) chronically infects >250 million people and kills nearly a million annually, and current antivirals cannot clear the infection or adequately suppress disease. The virus replicates by reverse transcription, and the dominant antiviral drugs are nucleos(t)ide analogs that target the viral reverse transcriptase. We are developing antivirals targeting the other essential viral enzymatic activity, the ribonuclease H (RNaseH). HBV RNaseH inhibitors with efficacies in the low micromolar to nanomolar range against viral replication in culture have been identified in the α-hydroxytropolone and hydroxyimide chemotypes. Here, we review the promise of RNaseH inhibitors, their current structure-activity relationships, and challenges to optimizing the inhibitors into leads for clinical assessment. © 2018 American Chemical Society