Early surgery prolongs professional activity in IDH mutant low-grade glioma patients: a policy change analysis

BackgroundUntil 2015, Dutch guidelines recommended follow-up and biopsy rather than surgery as initial care for suspected low-grade gliomas (LGG). Given evidence that surgery could extend patient survival, our center stopped following this guideline on January 1, 2010 and opted for early maximal safe resection of LGG. The effects of early surgery on the ability of patients to work remains little documented. MethodsA total of 104 patients operated on at our center between January 2000 and April 2013 and diagnosed with the WHO 2016 grade 2 astrocytoma, IDH mutant or oligodendroglioma, IDH mutant and deleted 1p19q were included. The clinical characteristics, survival, and work history of patients operated on before or after January 2010 were obtained from the patients' records and compared. The minimal follow-up was 8 years. ResultsAs per policy change, the interval between radiological diagnosis and first surgery decreased significantly after 2010. Likewise, before 2010, 25.8% of tumors were initially biopsied, 51.6% were resected under anesthesia, and 22.5% under awake conditions versus 14.3%, 23.8%, and 61.9% after this date (p < 0.001). The severity of permanent postoperative neurological deficits decreased after 2010. In total, 82.5% of the patients returned to work postoperatively before 2010 versus 100% after 2010. The postoperative control of epilepsy increased significantly after 2010 (74.4% vs. 47.9%). The median time from diagnosis to a definitive incapacity to work increased by more than 2 years after 2010 (88.7 vs. 62.2 months). ConclusionA policy shift towards early aggressive surgical treatment of IDH mutant LGG is safe and prolongs the patients' ability to work

Network Analyses of Maternal Pre- and Post-Partum Symptoms of Depression and Anxiety

10.3389/fpsyt.2020.00785Frontiers in Psychiatry1178

The influence of perceived parenting styles on socio-emotional development from pre-puberty into puberty

10.1007/s00787-017-1016-9European Child and Adolescent Psychiatry27137-4

Influence of birth weight on internalizing traits modulated by serotonergic genes

10.1542/peds.2010-3714Pediatrics1285e1250-e1258PEDI

Maternal Parenting Stress, Child Exuberance, and Preschoolers’ Behavior Problems

10.1111/cdev.13180Child Development901136-146CHDEAGUSTO (Growing up towards Healthy Outcomes

Micropaleontological counting methods and techniques : an exercise on an eight metres section of the lower Pliocene of Capo Rossello, Sicily

The LG.C.P. project 74/1/1 "a systems approach to accuracy in time", aims at a quantification of the refinement that may be attained with various methods of stratigraphic correlation. A considerable part of the pilot studies carried out by the "Dutch" working group deals with the application of numerical methods in biostratigraphy, in which one of the lines of research aims at a better understanding of counted numbers of specimens of individual taxa in suites of samples, as presented in so-called distribution charts or range charts. The biozonations constructed from such charts, from which in practice the more general zonation schemes are compiled, are commonly based on entries and exits of indivual taxa or groups of taxa. The corresponding datum levels based on single or multiple presence-absence criteria (as well as relatively high frequencies of taxa, so-called acmes) determine the zones recognized in the vertical successions. These methods and the actual counting on which they are - often unconsciously - based are being evaluated by the Utrecht team for several sections of the Mediterranean Neogene. The purpose of the present investigation was only to obtain a better documented insight in the reliability of different methods of collecting quantitative data

Flavonoid concentrations in three grass species and a sedge grown in the field and under controlled environment conditions in response to enhanced UV-B radiation.

An investigation was carried out to find whether enhanced levels of UV-B radiation induce increased concentrations of flavonoids in the leaves of the grass species Deschampsia antarctica, Deschampsia borealis and Calamagrostis epigeios and the sedge Carex arenaria. Whether the enhanced levels of UV-B influenced the proportions of the various flavonoids in the leaves was also studied. Increased flavonoid concentrations would improve the UV-B shielding of UV-B susceptible tissues. Using HPLC analysis the flavonoids orientin and luteolin were identified in D. antarctica, orientin in D. borealis and tricin in C. arenaria. Neither flavonoid concentrations nor the proportion of the various flavonoids in climate room grown D. antarctica and D. borealis plants differed between individuals grown under 0, ambient or elevated UV-B levels. After 12 weeks of growth biomass production and shoot-to-root ratios of D. antarctica were not affected by elevated UV-B radiation. Greenhouse grown C. epigeios plants contained higher concentrations and different proportions of flavonoids grown under elevated levels of UV-B than when grown under ambient or 0 UV-B. In C. epigeios plants grown in their natural habitat in the field under ambient or elevated levels of UV-B, flavonoid concentrations and proportions were the same in plants from both treatments. In the leaves of the sedge C. arenaria grown in a greenhouse flavonoid concentrations and proportions were not affected by UV-B radiation. Leaves were harvested four times during the growing season from C. arenaria plants grown in their natural habitat in the field under ambient or elevated levels of UV-B. Leaves harvested in January contained higher concentrations of flavonoids when grown under elevated UV-B than when grown under ambient UV-B radiation. In leaves harvested in May, September and December flavonoid concentrations were the same in plants grown under ambient or elevated UV-B. The proportion of the different flavonoids was the same for both treatments in all months. These results indicate that constitutive levels of flavonoids in these grass and sedge species are adequately high to protect them against ambient and elevated levels of solar UV-B radiation. © 2002 Elsevier Science B.V. All rights reserved

Inflammatory modulation of the associations between prenatal maternal depression and neonatal brain

10.1038/s41386-020-0774-0Neuropsychopharmacology462470 - 477NEROEGUSTO (Growing up towards Healthy Outcomes

Our children then and now: Changes in mental health symptoms among Singaporean children from 2003 to 2017

10.1016/j.ajp.2021.102773Asian Journal of Psychiatry6310277

Birth weight and catch up growth are associated with childhood impulsivity in two independent cohorts

10.1038/s41598-018-31816-5Scientific Reports8113705GUSTO (Growing up towards Healthy Outcomes