11 research outputs found
239 SPHINGOSINE-1-PHOSPHATE INHIBITSII-1 AND TNF-α INDUCED INOS EXPRESSION VIA S1P1 AND S1P2 IN HUMAN ARTICULAR CHONDROCYTES
233 THE NUCLEAR ORPHAN RECEPTOR NR4A3 IS REQUIRED FOR MMP-13 AND ADAMTS-5 EXPRESSION IN HUMAN CHONDROCYTES
397 PILOTSTUDY TO COMPARE EROSIVE OSTEOARTHRITIS (EOA) AND ARTHRITIS PSORIATICA (PSA) PATIENTS USING MRI TESLA 1.5 AS AN IMAGING TOOL
397 PILOTSTUDY TO COMPARE EROSIVE OSTEOARTHRITIS (EOA) AND ARTHRITIS PSORIATICA (PSA) PATIENTS USING MRI TESLA 1.5 AS AN IMAGING TOOL
268 LAMA4 IS EXPRESSED BY CLUSTERS OF HYPERTROPHIC CHONDROCYTES IN OSTEOARTHRITIC CARTILAGE AND REGULATED BY EPIGENETIC MECHANIMS
Salivary Gland Ultrasonography in Sjögren's Syndrome: A European Multicenter Reliability Exercise for the HarmonicSS Project
Objectives: Salivary gland ultrasonography (SGUS) is increasingly applied for the management of primary Sjögren's syndrome (pSS). This study aims to: (i) compare the reliability between two SGUS scores; (ii) test the reliability among sonographers with different levels of experience. Methods: In the reliability exercise, two four-grade semi-quantitative SGUS scoring systems, namely De Vita et al. and OMERACT, were tested. The sonographers involved in work-package 7 of the HarmonicSS project from nine countries in Europe were invited to participate. Different levels of sonographers were identified on the basis of their SGUS experience and of the knowledge of the tested scores. A dedicated atlas was used as support for SGUS scoring. Results: Twenty sonographers participated in the two rounds of the reliability exercise. The intra-rater reliability for both scores was almost perfect, with a Light's kappa of 0.86 for the De Vita et al. score and 0.87 for the OMERACT score. The inter-rater reliability for the De Vita et al. and the OMERACT score was substantial with Light's Kappa of 0.75 and 0.77, respectively. Furthermore, no significant difference was noticed among sonographers with different levels of experience. Conclusion: The two tested SGUS scores are reliable for the evaluation of major salivary glands in pSS, and even less-expert sonographers could be reliable if adequately instructed. © Copyright © 2020 Zabotti, Zandonella Callegher, Tullio, Vukicevic, Hocevar, Milic, Cafaro, Carotti, Delli, De Lucia, Ernst, Ferro, Gattamelata, Germanò, Giovannini, Hammenfors, Jonsson, Jousse-Joulin, Macchioni, Parisi, Perricone, Stradner, Filipovic, Tzioufas, Valent and De Vita