Ciguatoxins: Cyclic polyether modulators of voltage-gated Iion channel function

Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by neurological, cardiovascular and gastrointestinal disorders. The pharmacology of ciguatoxins is characterised by their ability to cause persistent activation of voltage-gated sodium channels, to increase neuronal excitability and neurotransmitter release, to impair synaptic vesicle recycling, and to cause cell swelling. It is these effects, in combination with an action to block voltage-gated potassium channels at high doses, which are believed to underlie the complex of symptoms associated with ciguatera. This review examines the sources, structures and pharmacology of ciguatoxins. In particular, attention is placed on their cellular modes of actions to modulate voltage-gated ion channels and other Na+-dependent mechanisms in numerous cell types and to current approaches for detection and treatment of ciguatera

Auger electron spectra : the basic data for understanding the Auger effect

peer reviewedSince the nineties, the Internet has seen an impressive growth, in terms of users, intermediate systems (such as routers), autonomous systems, or applications. In parallel to this growth, the research community has been looking for obtaining and modeling the Internet topology, i.e., how the various elements of the network interconnect between themselves. An impressive amount of work has been done regarding how to collect data and how to analyse and model it. This chapter reviews main approaches for gathering Internet topology data. We first focus on hop limited probing, i.e., traceroute-like probing. We review large-scale tracerouting projects and discuss traceroute limitations and how they are mitigated by new techniques or extensions. Hop limited probing can reveal an IP interface vision of the Internet. We next focus on techniques for aggregating several IP interfaces of a given router into a single identifier. This leads to a router level vision of the topology. The aggregation can be done through a process called alias resolution. We also review a technique based on IGMP probing that silently collect all multicast interfaces of a router into a single probe. We next refine the router level topology by adding subnet information. We finish this chapter by discussing the AS level topology, in particular the relationships between ASes and the induced hierarchy