105 research outputs found
Global Budget and Distribution of Peroxyacetyl Nitrate (PAN) for Present and Preindustrial Scenarios
Dramatic Regression of Chronic Lymphocytic Leukemia in the First Patient Treated With Donor-Derived Genetically-Engineered Anti-CD19-Chimeric-Antigen-Receptor-Expressing T Cells After Allogeneic Hematopoietic Stem Cell Transplantation
Continuity of the Maximum-Entropy Inference
We study the inverse problem of inferring the state of a finite-level quantum
system from expected values of a fixed set of observables, by maximizing a
continuous ranking function. We have proved earlier that the maximum-entropy
inference can be a discontinuous map from the convex set of expected values to
the convex set of states because the image contains states of reduced support,
while this map restricts to a smooth parametrization of a Gibbsian family of
fully supported states. Here we prove for arbitrary ranking functions that the
inference is continuous up to boundary points. This follows from a continuity
condition in terms of the openness of the restricted linear map from states to
their expected values. The openness condition shows also that ranking functions
with a discontinuous inference are typical. Moreover it shows that the
inference is continuous in the restriction to any polytope which implies that a
discontinuity belongs to the quantum domain of non-commutative observables and
that a geodesic closure of a Gibbsian family equals the set of maximum-entropy
states. We discuss eight descriptions of the set of maximum-entropy states with
proofs of accuracy and an analysis of deviations.Comment: 34 pages, 1 figur
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies
Aplicação da anĂĄlise multivariada em avaliaçÔes de divergĂȘncia genĂ©tica atravĂ©s de marcadores moleculares dominantes em plantas medicinais
Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer
On the feasibility of establishing the provenance of Australian Aboriginal artefacts using synchrotron radiation xrd and protoon-induced X-ray emission
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