14 research outputs found

    Preliminary fMRI Evidence of Visual System Dysfunction in Parkinson\u27s Disease Patients With Visual Hallucinations

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    Using functional magnetic resonance imaging (fMRI), the authors examined visual cortex function in Parkinson’s disease patients who did and did not experience visual hallucinations. Patients with visual hallucinations demonstrated increased activation in the visual association cortex and deficits in the primary visual cortex, suggesting that visual hallucinations are associated with an abnormality of visual-cortex function

    Unusual manifestations of type II cryoglobulinaemia associated with Waldenström's macroglobulinaemia

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    Cryoglobulinaemia in association with Waldenström's macroglobulinaemia is relatively common, ranging from 8% to 18% of cases; however, < 5% have symptoms or complications. We describe a patient with a history of cutaneous, peritoneal, and fallopian tube vasculitis related to type II cryoglobulinaemia associated with Waldenström's macroglobulinaemia. Cytotoxic treatment was initiated (cyclophosphamide, vincristine, and prednisone) and had a good initial response. However, after the third course of chemotherapy, the patient presented with septic shock and died. Even though cryoglobulinaemia is a model of systemic vasculitis, peritoneal and fallopian tube vasculitis associated with type II cryoglobulinemia has not been described previously. Key Words: cryoglobulinaemia • Waldenström's macroglobulinaemia • peritoneum • fallopian tub

    New Horizons: Scalar and Vector Ultralight Dark Matter

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    The last decade has seen unprecedented effort in dark matter model building at all mass scales coupled with the design of numerous new detection strategies. Transformative advances in quantum technologies have led to a plethora of new high-precision quantum sensors and dark matter detection strategies for ultralight (<10 <10\,eV) bosonic dark matter that can be described by an oscillating classical, largely coherent field. This white paper focuses on searches for wavelike scalar and vector dark matter candidates.The last decade has seen unprecedented effort in dark matter model building at all mass scales coupled with the design of numerous new detection strategies. Transformative advances in quantum technologies have led to a plethora of new high-precision quantum sensors and dark matter detection strategies for ultralight (<10 <10\,eV) bosonic dark matter that can be described by an oscillating classical, largely coherent field. This white paper focuses on searches for wavelike scalar and vector dark matter candidates

    Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics

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