The ovarian cancer oncobiome.

Humans and other mammals are colonized by microbial agents across the kingdom which can represent a unique microbiome pattern. Dysbiosis of the microbiome has been associated with pathology including cancer. We have identified a microbiome signature unique to ovarian cancers, one of the most lethal malignancies of the female reproductive system, primarily because of its asymptomatic nature during the early stages in development. We screened ovarian cancer samples along with matched, and non-matched control samples using our pan-pathogen array (PathoChip), combined with capture-next generation sequencing. The results show a distinct group of viral, bacterial, fungal and parasitic signatures of high significance in ovarian cases. Further analysis shows specific viral integration sites within the host genome of tumor samples, which may contribute to the carcinogenic process. The ovarian cancer microbiome signature provides insights for the development of targeted therapeutics against ovarian cancers

Large Deviations for Stochastic Evolution Equations with Small Multiplicative Noise

The Freidlin-Wentzell large deviation principle is established for the distributions of stochastic evolution equations with general monotone drift and small multiplicative noise. As examples, the main results are applied to derive the large deviation principle for different types of SPDE such as stochastic reaction-diffusion equations, stochastic porous media equations and fast diffusion equations, and the stochastic p-Laplace equation in Hilbert space. The weak convergence approach is employed in the proof to establish the Laplace principle, which is equivalent to the large deviation principle in our framework.Comment: 31 pages, published in Appl. Math. Opti

Two-Photon Doppler cooling of alkaline-earth-metal and ytterbium atoms

A new possibility of laser cooling of alkaline-earth-metal and Ytterbium atoms using a two-photon transition is analyzed. We consider a $^{1}S_{0}$ - $^{1}S_{0}$ transition, with excitation in near resonance with the $^{1}P_{1}$ level. This greatly increases the two-photon transition rate, allowing an effective transfer of momentum. The experimental implementation of this technique is discussed and we show that for Calcium, for example, two-photon cooling can be used to achieve a Doppler limit of 123 microKelvin. The efficiency of this cooling scheme and the main loss mechanisms are analyzed.Comment: 7 pages, 5 figure

Fractional Exclusion Statistics and Anyons

Do anyons, dynamically realized by the field theoretic Chern-Simons construction, obey fractional exclusion statistics? We find that they do if the statistical interaction between anyons and anti-anyons is taken into account. For this anyon model, we show perturbatively that the exchange statistical parameter of anyons is equal to the exclusion statistical parameter. We obtain the same result by applying the relation between the exclusion statistical parameter and the second virial coefficient in the non-relativistic limit.Comment: 9 pages, latex, IFT-498-UN

Dynamical electron transport through a nanoelectromechanical wire in a magnetic field

We investigate dynamical transport properties of interacting electrons moving in a vibrating nanoelectromechanical wire in a magnetic field. We have built an exactly solvable model in which electric current and mechanical oscillation are treated fully quantum mechanically on an equal footing. Quantum mechanically fluctuating Aharonov-Bohm phases obtained by the electrons cause nontrivial contribution to mechanical vibration and electrical conduction of the wire. We demonstrate our theory by calculating the admittance of the wire which are influenced by the multiple interplay between the mechanical and the electrical energy scales, magnetic field strength, and the electron-electron interaction

Thermal Stabilization of the HCP Phase in Titanium

We have used a tight-binding model that is fit to first-principles electronic-structure calculations for titanium to calculate quasi-harmonic phonons and the Gibbs free energy of the hexagonal close-packed (hcp) and omega crystal structures. We show that the true zero-temperature ground-state is the omega structure, although this has never been observed experimentally at normal pressure, and that it is the entropy from the thermal population of phonon states which stabilizes the hcp structure at room temperature. We present the first completely theoretical prediction of the temperature- and pressure-dependence of the hcp-omega phase transformation and show that it is in good agreement with experiment. The quasi-harmonic approximation fails to adequately treat the bcc phase because the zero-temperature phonons of this structure are not all stable

Generalized measurements by linear elements

I give a first characterization of the class of generalized measurements that can be exactly realized on a pair of qudits encoded in indistinguishable particles, by using only linear elements and particle detectors. Two immediate results follow from this characterization. (i) The Schmidt number of each POVM element cannot exceed the number of initial particles. This rules out any possibility of performing perfect Bell-measurements for qudits. (ii) The maximum probability of performing a generalized incomplete Bell-measurement is 1/2.Comment: 4 pages. Submitted to Phys. Rev.

Conditions for the freezing phenomena of geometric measure of quantum discord for arbitrary two-qubit X states under non-dissipative dephasing noises

We study the dynamics of geometric measure of quantum discord (GMQD) under the influences of two local phase damping noises. Consider the two qubits initially in arbitrary X-states, we find the necessary and sufficient conditions for which GMQD is unaffected for a finite period. It is further shown that such results also hold for the non-Markovian dephasing process.Comment: 4 pages, 2 figure

Cosmic histories of star formation and reionization: An analysis with a power-law approximation

With a simple power-law approximation of high-redshift ($\gtrsim3.5$) star formation history, i.e., $\dot{\rho}_*(z)\propto [(1+z)/4.5]^{-\alpha}$, we investigate the reionization of intergalactic medium (IGM) and the consequent Thomson scattering optical depth for cosmic microwave background (CMB) photons. A constraint on the evolution index $\alpha$ is derived from the CMB optical depth measured by the {\it Wilkinson Microwave Anisotropy Probe} (WMAP) experiment, which reads $\alpha\approx2.18\lg{\mathscr{N}_{\gamma}}-3.89$, where the free parameter $\mathscr{N}_\gamma$ is the number of the escaped ionizing ultraviolet photons per baryon. Moreover, the redshift for full reionization, $z_f$, can also be expressed as a function of $\alpha$ as well as $\mathscr{N}_{\gamma}$. By further taking into account the implication of the Gunn-Peterson trough observations to quasars for the full reionization redshift, i.e., $6\lesssim z_f \lesssim7$, we obtain $0.3\lesssim\alpha\lesssim1.3$ and $80\lesssim\mathscr{N}_{\gamma}\lesssim230$. For a typical number of $\sim4000$ of ionizing photons released per baryon of normal stars, the fraction of these photons escaping from the stars, $f_{\rm esc}$, can be constrained to within the range of $(2.0-5.8)$.Comment: 10 pages, 4 figures, accepted for publication in JCA