21 research outputs found
Expression of odorant-binding protein 1F in rat olfactory mucosa is regulated by nutritional status
National audienc
L'expression de l'OBP-1F dans la muqueuse olfactive de rat est régulée par l'état nutritionnel
National audienc
Transcription profile analysis reveals that OBP-1F mRNA is downregulated in the olfactory mucosa following food deprivation
International audienc
Imager au-delà de la limite de diffraction grâce à la microscopie STED
International audienc
Parvalbumin-deficiency affects network properties resulting in increased susceptibility to epileptic seizure
Networks of GABAergic interneurons are of utmost importance in generating and promoting synchronous activity and are involved in producing coherent oscillations. These neurons are characterized by their fast-spiking rate and by the expression of the Ca2+-binding protein parvalbumin (PV). Alteration of their inhibitory activity has been proposed as a major mechanism leading to epileptic seizures and thus the role of PV in maintaining the stability of neuronal networks was assessed in knockout (PV-/-) mice. Pentylenetetrazole induced generalized tonic-clonic seizures in all genotypes, but the severity of seizures was significantly greater in PV-/- than in PV+/+ animals. Extracellular single-unit activity recorded from over 1000 neurons in vivo in the temporal cortex revealed an increase of units firing regularly and a decrease of cells firing in bursts. In the hippocampus, PV deficiency facilitated the GABA(A)ergic current reversal induced by high-frequency stimulation, a mechanism implied in the generation of epileptic activity. We postulate that PV plays a key role in the regulation of local inhibitory effects exerted by GABAergic interneurons on pyramidal neurons. Through an increase in inhibition, the absence of PV facilitates synchronous activity in the cortex and facilitates hypersynchrony through the depolarizing action of GABA in the hippocampus
Mutating the cholesterol binding site on amyloid precursor protein alters the processing and production of Aβ-amyloid peptides
International audienc
Mutating the cholesterol binding site on amyloid precursor protein alters the processing and production of Aβ-amyloid peptides
International audienc
Classification of variations of HSA21 gene expression in down syndrome lymphoblastoid cell lines : impact on disease phenotype
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