Aggressive behavior of pregnant mice toward males

Aggressive behavior toward male intruders was compared between pregnant, pseudopregnant, and virgin females during a series of successive daily encounters. The pregnant and the pseudopregnant females obtained significantly higher scores than the virgins. Changes in ovarian activity may be a determinant of the female aggression toward males.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development

SummaryThe establishment of functional neural circuits requires the guidance of axons in response to the actions of secreted and cell-surface molecules such as the semaphorins. Semaphorin 3E and its receptor PlexinD1 are expressed in the brain, but their functions are unknown. Here, we show that Sema3E/PlexinD1 signaling plays an important role in initial development of descending axon tracts in the forebrain. Early errors in axonal projections are reflected in behavioral deficits in Sema3E null mutant mice. Two distinct signaling mechanisms can be distinguished downstream of Sema3E. On corticofugal and striatonigral neurons expressing PlexinD1 but not Neuropilin-1, Sema3E acts as a repellent. In contrast, on subiculo-mammillary neurons coexpressing PlexinD1 and Neuropilin-1, Sema3E acts as an attractant. The extracellular domain of Neuropilin-1 is sufficient to convert repulsive signaling by PlexinD1 to attraction. Our data therefore reveal a “gating” function of neuropilins in semaphorin-plexin signaling during the assembly of forebrain neuronal circuits