Long-term Output From Amlodipine Or Enalapril Treated Hypertensives With Left Ventricular Hypertrophy [alteracoes Na Remodelacao Ventricular A Longo Prazo Pelo Tratamento Com Amlodipina Ou Enalapril Para Hipertensos Com Hipertrofia Ventricular Esquerda]

57 hypertensives with LVH underwent wash-out with placebo for 4 weeks before randomization. For the following 24 weeks, 20 patients received amlodipine and 21 enalapril on doses respectively of 5-10mg, and 10-20mg. Echocardiographic and ABPM changes were prospectively analysed and revealed, despite similar blood lowering effects from both therapies, a significative reduction in 6 of the 7 echocardiographic variables with amlodipine and 3 with enalapril. These variables were related either to LV mass or to diastolic function. Of the 12 ABPM variables studied both regimens led to marked reductions, except for two night time variables in the enalapril group. It is concluded that both treatments are effective in bringing about regression of signs of LVH in hypertension.561-26577Kannel, W.B., Gordon, T., Offut, D., Lett Ventricular Hypertrophy by Electrocardiogram. Prevalence, Incidence and Mortality in the Framingham Study (1969) Ann Intern Med, 71, pp. 89-101De Simone, G., Ganau, A., Verdecchia, P., Devereux, R.B., Echocardiography in arterial hypertension: When, why and how? (1994) J Hypertens, 12, pp. 1129-1136Schillaci, G., Verdecchia, P., Borgioni, C., Association between Persistent Pressure Overload and Ventricular Arrhythmias in Essential Hypertension (1996) Hypertension, 28, pp. 284-289Messerli, F.H., Ventura, H.O., Elizardi, D.J., Dunn, F.G., Frohlich, E.D., Hypertension and sudden death: Increased ventricular ectopic activity in left ventricular hypertrophy (1984) Am J Med, 77, pp. 18-22Neaton, J.D., Grimm, R.H., Preneas, R.J., Treatment of Mild Hypertension Study (TOMHS) (1993) J Am Med Assoc, 270, pp. 713-724Hoes, A.W., De Grobbee, Lubsen, J., Diuretics, B-Blockers, and the risk for sudden cardiac death in hypertensive patients (1995) Ann Intern Med, 123, pp. 481-487Casale, P.N., Devereux, R.B., Alonso, D.R., Improved sex-specific criteria of left ventricular hypertrophy for clinical and computer interpretation of electrocardiograms: Validation with autopsy findings (1987) Circulation, 75, pp. 565-572The Fifth Report of the Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure. JNC V (1993) Arch Intern Med, 153, pp. 154-183Hammond, I.W., Devereux, R.B., Aldermann, M.A., The prevalence and correlates of echocardiographic left ventricular hypertrophy among employed patients with uncomplicated hypertension (1986) J Am Coll Cardiol, 7, pp. 639-650Byrd, B.F., Wahr, D., Wang, Y.S., Left ventricular mass and volume/mass ratio determined by two-dimensional echocardiography in normal adults (1985) J Am Coll Cardiol, 6, pp. 1021-1025Levy, D., Savage, D.D., Garrison, R.J., Echocardiographic criteria for left ventricular hypertrophy: The Framingham Heart Study (1987) Am J Cardiol, 59, pp. 956-960Koren, M.J., Devereux, R.B., Casale, P.N., Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension (1991) Ann Intern Med, 114, pp. 345-352Papademetriou, V., Gottdiener, J.S., Fletcher, R.D., Diastolic left ventricular function and left ventricular hypertrophy in patients with borderline or mild hypertension. Echocardiographic assessment by computer-assisted analysis (1985) Am J Cardiol, 56, pp. 546-550Gardin, J.M., Drayer, J.I.M., Weber, M., (1987) Echocardiographic Assessment of Left Ventricular Systolic and Diastolic Function in Mild Hypertension, 9 (2 SUPPL.). , II-90-6Ren, J.F., Pancholy, S.B., Iskandrian, A.S., Doppler echocardiographic evaluation of the spectrum of left ventricular diastolic dysfunction in essential hypertension (1994) Am Heart J, 127, pp. 906-913Omvik, P., Thaulow, E., Herland, O.B., Double-blind, Parallel, Comparative Study on Quality of Life during Treatment with Amlodipine or Enalapril in Mild to Moderate Hypertensive Patients (1993) J Hypert, 11, pp. 103-113Fowler, G., Webster, J., Lyons, D., A comparison of Amlodipine with Enalapril in the Treatment of Moderate/Severe Hypertension (1993) Br J Clin Pharm, 35, pp. 491-498Liebson, P.R., Clinical studies of drug reversal of hypertensive left ventricular hypertrophy (1990) Am J Hypertens, 3, p. 512Agabiti-Rosei, E., Muiesan, M.L., Rizzoni, D., Cardiovascular structural changes and calcium antagonist therapy in patients with hypertension (1994) J Cardiovasc Pharmacol, 24 (SUPPL. A), pp. S37-43Lyons, D., Webster, J., Benjamin, N., The effect of antihypertensive therapy on responsiveness to local intra-arterial NG-monomethyl-L-arginine in patients with essential hypertension J Hyperten