7,065 research outputs found
Analysis of pressure blips in aft-finocyl solid rocket motor
Ballistic anomalies have frequently occurred during the firing of several solid rocket motors (SRMs) (Inertial Upper Stage, Space Shuttle Redesigned SRM (RSRM) and Titan IV SRM Upgrade (SRMU)), producing even relevant and unexpected variations of the SRM pressure trace from its nominal profile. This paper has the purpose to provide a numerical analysis of the following possible causes of ballistic anomalies in SRMs: an inert object discharge, a slag ejection, and an unexpected increase in the propellant burning rate or in the combustion surface. The SRM configuration under investigation is an aft-finocyl SRM with a first-stage/small booster design. The numerical simulations are performed with a quasi-one-dimensional (Q1D) unsteady model of the SRM internal ballistics, properly tailored to model each possible cause of the ballistic anomalies. The results have shown that a classification based on the head-end pressure (HEP) signature, relating each other the HEP shape and the ballistic anomaly cause, can be made. For each cause of ballistic anomalies, a deepened discussion of the parameters driving the HEP signatures is provided, as well as qualitative and quantitative assessments of the resultant pressure signals
A 22-Week-Old Fetus with Nager Syndrome and Congenital Diaphragmatic Hernia due to a Novel SF3B4 Mutation.
Nager syndrome, or acrofacial dysostosis type 1 (AFD1), is a rare multiple malformation syndrome characterized by hypoplasia of first and second branchial arches derivatives and appendicular anomalies with variable involvement of the radial/axial ray. In 2012, AFD1 has been associated with dominant mutations in SF3B4. We report a 22-week-old fetus with AFD1 associated with diaphragmatic hernia due to a previously unreported SF3B4 mutation (c.35-2A>G). Defective diaphragmatic development is a rare manifestation in AFD1 as it is described in only 2 previous cases, with molecular confirmation in 1 of them. Our molecular finding adds a novel pathogenic splicing variant to the SF3B4 mutational spectrum and contributes to defining its prenatal/fetal phenotype
Reference priors for high energy physics
Bayesian inferences in high energy physics often use uniform prior
distributions for parameters about which little or no information is available
before data are collected. The resulting posterior distributions are therefore
sensitive to the choice of parametrization for the problem and may even be
improper if this choice is not carefully considered. Here we describe an
extensively tested methodology, known as reference analysis, which allows one
to construct parametrization-invariant priors that embody the notion of minimal
informativeness in a mathematically well-defined sense. We apply this
methodology to general cross section measurements and show that it yields
sensible results. A recent measurement of the single top quark cross section
illustrates the relevant techniques in a realistic situation
Maximum Entropy and Bayesian Data Analysis: Entropic Priors
The problem of assigning probability distributions which objectively reflect
the prior information available about experiments is one of the major stumbling
blocks in the use of Bayesian methods of data analysis. In this paper the
method of Maximum (relative) Entropy (ME) is used to translate the information
contained in the known form of the likelihood into a prior distribution for
Bayesian inference. The argument is inspired and guided by intuition gained
from the successful use of ME methods in statistical mechanics. For experiments
that cannot be repeated the resulting "entropic prior" is formally identical
with the Einstein fluctuation formula. For repeatable experiments, however, the
expected value of the entropy of the likelihood turns out to be relevant
information that must be included in the analysis. The important case of a
Gaussian likelihood is treated in detail.Comment: 23 pages, 2 figure
Counting States: A Combinatorial Analysis of SQM Fragmentation
The Strange Quark matter (SQM) hypothesis states that at extreme pressure and
density conditions a new ground state of matter would arise, in which half of
the \textit{down} quarks become strange quarks. If true, it would mean that at
least the core of neutron stars is made of SQM. In this hypothesis, SQM would
be released in the inter-stellar medium when two of these objects merge. It is
estimated that of SQM would be released this way. This matter
will undergo a sequence of processes that should result in a fraction of the
released SQM becoming heavy nuclei through \textit{r-process}. In this work we
are interested in characterizing the fragmentation of SQM, with the novelty of
keeping track of the \textit{quark configuration} of the fragmented matter.
This is accomplished by developing a methodology to estimate the energy of each
fragment as the sum of its \textit{constituent quarks}, the Coulomb interaction
among the quarks and fragments' momenta. The determination of the fragmentation
output is crucial to fully characterize the subsequent nucleosynthesis.Comment: 4 pages, 2 figures, 2 table
Functional bioglass/carbon nanocomposite scaffolds from vat photopolymerization of a novel preceramic polymer-based nanoemulsion
Silicone polymers are already known as feedstock for a variety of silicate bioceramics, in the form of scaffolds with complex shapes, obtained by Vat Photopolymerization. Printing is enabled by using silicone blended with photocurable acrylates. The development of a particular silicate composition that functions as a glass or glass-ceramic precursor is possible by the addition of suitable oxide fillers (especially carbonate powders), suspended in the polymer blend. Oxides, from the fillers, easily react with silica left by the thermal transformation of the silicone. The fillers, however, also determine complications in Vat Photopolymerization, due to light scattering; in addition, local oxide concentrations generally impede the obtainment of glassy products. The present paper illustrates a simple solution to these issues, based on the inclusion of a Ca salt in nano-emulsion within a silicone-containing blend. Homogeneous printed samples are later converted into crack-free, fully amorphous ceramic composites, by firing at only 700 °C. The glass matrix, resembling 70S30C (70 % SiO2 and 30 % CaO) bioglass, is achieved according to the quasi-molecular CaO distribution. The secondary phase, promoted by treatment in N2 atmosphere and consisting of pyrolytic carbon, provides a marked photothermal effect
Noise Enhanced Stability in Fluctuating Metastable States
We derive general equations for the nonlinear relaxation time of Brownian
diffusion in randomly switching potential with a sink. For piece-wise linear
dichotomously fluctuating potential with metastable state, we obtain the exact
average lifetime as a function of the potential parameters and the noise
intensity. Our result is valid for arbitrary white noise intensity and for
arbitrary fluctuation rate of the potential. We find noise enhanced stability
phenomenon in the system investigated: the average lifetime of the metastable
state is greater than the time obtained in the absence of additive white noise.
We obtain the parameter region of the fluctuating potential where the effect
can be observed. The system investigated also exhibits a maximum of the
lifetime as a function of the fluctuation rate of the potential.Comment: 7 pages, 5 figures, to appear in Phys. Rev. E vol. 69 (6),200
Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy.
Background: Hypertrophic cardiomyopathy (HCM) is a common genetic heart disorder characterized by
unexplained left ventricle hypertrophy associated with non-dilated ventricular chambers. Several genes
encoding heart sarcomeric proteins have been associated to HCM, but a small proportion of HCM patients
harbor alterations in other non-sarcomeric loci. The variable expression of HCM seems influenced by genetic
modifier factors and new sequencing technologies are redefining the understanding of genotype–phenotype
relationships, even if the interpretations of the numerous identified variants pose several challenges.
Methods and results: We investigated 62 sarcomeric and non-sarcomeric genes in 41 HCM cases and in
3 HCM-related disorders patients. We employed an integrated approach that combines multiple tools for
the prediction, annotation and visualization of functional variants. Genotype–phenotype correlations
were carried out for inspecting the involvement of each gene in age onset and clinical variability of HCM. The
80% of the non-syndromic patients showed at least one rare non-synonymous variant (nsSNV) and among
them, 58% carried alterations in sarcomeric loci, 14% in desmosomal and 7% in other non-sarcomeric ones
without any sarcomere change. Statistical analyses revealed an inverse correlation between the number of
nsSNVs and age at onset, and a relationship between the clinical variability and number and type of variants.
Conclusions: Our results extend the mutational spectrum of HCM and contribute in defining the molecular
pathogenesis and inheritance pattern(s) of this condition. Besides, we delineate a specific procedure for the
identification of the most likely pathogenetic variants for a next generation sequencing approach embodied in
a clinical context
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