Marked increase in the incidence rate of esophageal adenocarcinoma in a high-risk area for esophageal cancer

BACKGROUND: Esophageal cancer (EC) is the eighth common cancer worldwide. Esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAD) are the most common histologic types of EC. Many recent reports showed an increasing trend in EAD and a decreasing trend in ESCC in many Western countries. Golestan Province in northeastern Iran has been known as a high-risk area for EC. The aim of this study was to describe the time trend of EAD in this area between 2000-2009. METHODS: Data on cancer cases were obtained from Golestan Population-based Cancer Registry. Analysis was done using Joinpoint software. To examine the incidence trends, the annual percent change was calculated. The possibilities of anatomic and histologic misclassification were considered by assessing the trend of ESCC and gastric adenocarcinoma. RESULTS: A total number of 1186 histologically-confirmed EC cases were recruited. The incidence rate of EAD showed a significant increasing trend. There was no significant trend in the incidence of ESCC during the study period. A significant increase in the incidence rate of gastric adenocarcinoma was observed during the period of 2000-2005, followed by a plateau during the period of 2005-2009. CONCLUSIONS: We found a significant increasing trend in the incidence rate of EAD. We find no evidence to support an alternative explanation including anatomic and histologic misclassification. So, the observed rise in the incidence of EAD seems to be real. Therefore, designing and implementation of control programs, including control of preventable risk factors of EAD, should be considered in this high- risk area

Altered pituitary hormone secretion in male rats exposed to Bisphenol A

Bisphenol A (BPA) is a xenobiotic estrogenic compound. This compound has been suspected to have estrogenic effects on reproductive system of males and females. In this present study we investigated possible low-dose effects of BPAon Luteinizing Hormone in rats. Male Wistar rats (12-13 weeks old) were administrated a daily intra peritoneal 10 μg/kgbw/day, 50 μg/kgbw/day, 100 μg/kgbw/ day dose of BPA for 6, 6, and 12 days, and one day after last injection, serum level of Luteinizing Hormone was examined by ELISA method. All data were expressed as means ± SE. Two-way ANOVA was performed. Analysis of data showed that in all dose groups, plasma level of Luteinizing Hormone significantly decreased compared to control group. The present study showed that BPA at low doses affects Luteinizing Hormone, one of main hormones in spermatogenesis in the adult Wistar rats, and subsequently alters the steroidgenesis in testicular Leydig cells

Effects of dietary isoflavone-genistein on hematological and immunological parameters in pre-brood stock beluga, Huso huso

This study was carried out with the aim of detecting the dietary effects of isoflavone-genistein on hematological and immunological parameters in beluga, Huso huso in a 12-week feeding period. Five isonitrogenous (45% crude protein) and isoenergetic (19.5 MJ kg^-1) diets were formulated to contain four graded levels of isoflavone-genistein, namely 0, 0.2, 0.4, 0.8 and 1.6 g kg^-1 diet. Fish (initial average weight: 26.1 ± 1.8 kg) were stocked in ponds in groups of 3 and fed the experimental diets in triplicate. At the end of experiment, physiological indicators, including hematological and immunological parameters, such as red blood cell (RBC), white blood cell count (WBC), hematocrit (Ht), hemoglobin (Hb), lymphocyte, neutrophil, eosinophil, monocyte, haematological indices, lysozyme, total immunoglobulin (IgM) and complementary activities were determined. Results suggested that mean corpuscular hemoglobin concentration (MCHC) and values of neutrophil had significant differences between treatments. The activities of serum lysozyme, IgM, C3 and C4 were significantly influenced by the dietary genistein concentrations. Results indicated that genistein had significant effects on some hematological and immunological parameters in beluga

Determinants of healthcare utilisation and predictors of outcome in colorectal cancer patients from Northern Iran

We aimed to assess healthcare utilisation (HU), its determinants, as well as its relationship with survival in colorectal cancer (CRC) patients. This study was conducted on incident CRC cases from Northern Iran. Information on HU was collected using a valid questionnaire, considering eight diagnostic and four therapeutic services. The results were categorised as good and poor HU. Multivariate logistic regression analysis was used to assess the relationship between HU and other variables. Cox regression analysis was performed to determine major predictors of survival. In total, 227 new cases of CRC were enrolled. HU could be assessed in 218 subjects (96). Living in rural areas was the strongest variable related to poor HU (adjusted OR, odds ratio=2.65; CI, confidence interval: 1.30-5.40). The median survival time was 40.5months. The 1-, 3- and 5-year survival rates were 71, 52 and 44 respectively. Cox regression analysis showed a significant lower survival rate in patients with poor HU (HR=2.3; CI: 1.46-3.64). HU was an independent predictor of survival in our CRC patients. Patients' place of residence was a significant determinant of HU. Regarding its effects on patients' outcome, HU and its determinants should be considered in designing CRC controlling programmes in our region and similar high-risk populations. © 2016 John Wiley & Sons Ltd

A Competition-based Pricing Strategy in Cloud Markets using Regret Minimization Techniques

Cloud computing as a fairly new commercial paradigm, widely investigated by different researchers, already has a great range of challenges. Pricing is a major problem in Cloud computing marketplace; as providers are competing to attract more customers without knowing the pricing policies of each other. To overcome this lack of knowledge, we model their competition by an incomplete-information game. Considering the issue, this work proposes a pricing policy related to the regret minimization algorithm and applies it to the considered incomplete-information game. Based on the competition based marketplace of the Cloud, providers update the distribution of their strategies using the experienced regret. The idea of iteratively applying the algorithm for updating probabilities of strategies causes the regret get minimized faster. The experimental results show much more increase in profits of the providers in comparison with other pricing policies. Besides, the efficiency of a variety of regret minimization techniques in a simulated marketplace of Cloud are discussed which have not been observed in the studied literature. Moreover, return on investment of providers in considered organizations is studied and promising results appeared

Studying the correlation between serum level of 25-hydroxyvitamin D and glucose metabolism during pregnancy

There are conflicting ideas concerning the correlation between serum levels of 25- hydroxivatmin D and side effects of pregnancy. The present research seeks to study the correlation between lack of this vitamin and glucose metabolism in pregnancy. In this Cross-sectional research, as many as 330 women aging 18 to 35 in the 24th to 28th week of their pregnancy and fully aware of the process entered this project after their consent was gained. They underwent public screening for diabetes through 50-gram oral glucose challenge test (GCT). The serum level of HbA1C and 25-hydroxyvitamin D and analysis of urine for glucose were measured at the same time when the level of blood sugar was assessed. As for those people whose blood sugar 1 hour after receiving 50 g oral glucose was equal to or more than 140 mg/dl, the two-hour OGTT diagnosis test was carried out with 75 grams of glucose. The average levels of Vitamin D and HbA1C were compared with one another among the participants. Variables such as mother's age, parity, family history of diabetes, and BMI of mother were recorded in the checklists. Data was analyzed by SPSS20 software using T-test, Correlation, and K2 statistical methods. The average age of the mothers participating in this research and their average level of parity were 26.78 ± 4.5 and 1.89 ± 0.92 respectively. There were 48 cases (14.5) with pregnancy diabetes, while 282 cases (85.5) had no sign of diabetes. The serum level of vitamin D was above 30 ng/dl in 9 subjects (2.7), while this level was below 20 ng/dl in 321 people (93.7). A reverse significant correlation was observed between the serum level of vitamin D and average levels of HbA1C (p=0.006 and r=0.15). a significant difference was observed in Glucosuria between the diabetic and non-diabetic people (p=0.001) but it had no significant correlation between the level of vitamin D. Prevalence of vitamin D deficiency in this research is really high. The routine assessment of this vitamin before pregnancy and the necessity of correcting its deficiency and prescription of Vitamin D supplements and its effect on OGTT results,needs more researches