Relative Value Iteration for Stochastic Differential Games

We study zero-sum stochastic differential games with player dynamics governed by a nondegenerate controlled diffusion process. Under the assumption of uniform stability, we establish the existence of a solution to the Isaac's equation for the ergodic game and characterize the optimal stationary strategies. The data is not assumed to be bounded, nor do we assume geometric ergodicity. Thus our results extend previous work in the literature. We also study a relative value iteration scheme that takes the form of a parabolic Isaac's equation. Under the hypothesis of geometric ergodicity we show that the relative value iteration converges to the elliptic Isaac's equation as time goes to infinity. We use these results to establish convergence of the relative value iteration for risk-sensitive control problems under an asymptotic flatness assumption

Accelerating vaccine development and deployment: report of a Royal Society satellite meeting.

The Royal Society convened a meeting on the 17th and 18th November 2010 to review the current ways in which vaccines are developed and deployed, and to make recommendations as to how each of these processes might be accelerated. The meeting brought together academics, industry representatives, research sponsors, regulators, government advisors and representatives of international public health agencies from a broad geographical background. Discussions were held under Chatham House rules. High-throughput screening of new vaccine antigens and candidates was seen as a driving force for vaccine discovery. Multi-stakeholder, small-scale manufacturing facilities capable of rapid production of clinical grade vaccines are currently too few and need to be expanded. In both the human and veterinary areas, there is a need for tiered regulatory standards, differentially tailored for experimental and commercial vaccines, to allow accelerated vaccine efficacy testing. Improved cross-fertilization of knowledge between industry and academia, and between human and veterinary vaccine developers, could lead to more rapid application of promising approaches and technologies to new product development. Identification of best-practices and development of checklists for product development plans and implementation programmes were seen as low-cost opportunities to shorten the timeline for vaccine progression from the laboratory bench to the people who need it

On relativization of the Sommerfeld-Gamow-Sakharov factor

The Sommerfeld-Gamow-Sakharov factor is considered for the general case of arbitrary masses and energies. It is shown that the scalar triangular one-loop diagram gives the Coulomb singularity in radiative corrections at the threshold. The singular part of the correction is factorized at the complete Born cross section regardless of its partial wave decomposition. Different approaches to generalize the factor are discussed.Comment: 9 pages, 4 figures; references and discussion are extende

The next-to-leading order forward jet vertex in the small-cone approximation

We consider within QCD collinear factorization the process p+p to jet + jet +X, where two forward high-$p_T$ jets are produced with a large separation in rapidity $\Delta y$ (Mueller-Navelet jets). In this case the (calculable) hard part of the reaction receives large higher-order corrections $\sim \alpha^n_s (\Delta y)^n$, which can be accounted for in the BFKL approach. In particular, we calculate in the next-to-leading order the impact factor (vertex) for the production of a forward high-$p_T$ jet, in the approximation of small aperture of the jet cone in the pseudorapidity-azimuthal angle plane. The final expression for the vertex turns out to be simple and easy to implement in numerical calculations.Comment: 32 pages, 4 figures; a few comments and one reference added; a few inessential misprints removed; version to appear on JHE

Inclusive production of a pair of hadrons separated by a large interval of rapidity in proton collisions

We consider within QCD collinear factorization the inclusive process $p+p\to h_1+h_2+X$, where the pair of identified hadrons, $h_1,h_2$, having large transverse momenta is produced in high-energy proton-proton collisions. In particular, we concentrate on the kinematics where the two identified hadrons in the final state are separated by a large interval of rapidity $\Delta y$. In this case the (calculable) hard part of the reaction receives large higher order corrections $\sim \alpha^n_s \Delta y^n$. We provide a theoretical input for the resummation of such contributions with next-to-leading logarithmic accuracy (NLA) in the BFKL approach. Specifically, we calculate in NLA the vertex (impact-factor) for the inclusive production of the identified hadron. This process has much in common with the widely discussed Mueller-Navelet jets production and can be also used to access the BFKL dynamics at proton colliders. Another application of the obtained identified-hadron vertex could be the NLA BFKL description of inclusive forward hadron production in DIS.Comment: 29 pages, 9 figures; corrected few typos and added an acknowledgment; version to be published on JHEP. arXiv admin note: substantial text overlap with arXiv:1202.108

Report of Acoustic Test on PSLV IS.1/2L Structure

The results of acoustic conducted on PSLV IS.1/2L at Acoustic Test Facility are briefly given. It contains test set up, Instrumentation details and tables of spectral response

Hysteresis of Backflow Imprinted in Collimated Jets

We report two different types of backflow from jets by performing 2D special relativistic hydrodynamical simulations. One is anti-parallel and quasi-straight to the main jet (quasi-straight backflow), and the other is bent path of the backflow (bent backflow). We find that the former appears when the head advance speed is comparable to or higher than the local sound speed at the hotspot while the latter appears when the head advance speed is slower than the sound speed bat the hotspot. Bent backflow collides with the unshocked jet and laterally squeezes the jet. At the same time, a pair of new oblique shocks are formed at the tip of the jet and new bent fast backflows are generated via these oblique shocks. The hysteresis of backflow collisions is thus imprinted in the jet as a node and anti-node structure. This process also promotes broadening of the jet cross sectional area and it also causes a decrease in the head advance velocity. This hydrodynamic process may be tested by observations of compact young jets.Comment: 9 pages, 5 figures, accepted for publication in ApJ

EFFECT OF PUNARNAVADI KASHAYAM AND ASWAGANDHA CHOORNA IN PREMENSTRUAL SYNDROME

Premenstrual syndrome (PMS) is a common disorder of young and middle-aged women characterized by cyclic occurrence in the luteal phase of the menstrual cycle of a combination of distressing physical, psychological and behavioral changes of sufficient severity to result in deterioration of inter- personal relationships; which remit upon onset or immediately after menstruation. PMS is due to doshic imbalance and impairment of satwa. Objective of study is to find out the effect of Punarnavadi kashayam and Aswagandha choornam in Premenstrual syndrome. Study design was interventional, pre and posttest with a sample size of 20. Females of age group 20-35 years with PMS fulfilling the American College of Obstetrics and Gynecology criteria of PMS was selected. Punarnavadi Kashayam in the dose of 48 ml bid, 30 minutes before food and Aswagandha choorna in the dose of 3 gm. bid along with kashaya. Administration of drug started 14 days before menstruation and was continued till fourth day of menstruation for three consecutive cycles. Follow up was done for next two consecutive cycles. Patient was assessed on fifth day of menstruation during study period and follow up period. The research drug had shown effectiveness in the treatment of depressive effect, anxiety, fatigue, irritation, depressive thoughts, pain, appetite changes, sleep changes, bloating assessed by premenstrual scale. Both drugs showed effectiveness in normalizing serum sodium and serum potassium levels. Associated premenstrual complaints also subsided. Study concluded that Punarnavadi kashaya and Aswagandha choorna is very much effective in treating Premenstrual syndrome

Diastolic And Systolic Right Ventricular Dysfunction Precedes Left Ventricular Dysfunction In Patients Paced From Right Ventricular Apex

Background: Cardiac dysfunction after right ventricular (RV) apical pacing is well known but its extent, time frame of appearance and individual effect on left ventricular (LV), RV systolic and diastolic parameters has not evaluated in a systematic fashion. Methods: Patients with symptomatic bradycardia and ACC-AHA Class I indication for permanent pacemaker implantation (PPI) were implanted a single chamber (VVI) pacemaker. They were followed prospectively by echocardiographic examination which was done at baseline, 1 week, 1 month and 6 months after implantation. Parameters observed were chamber dimensions (M-line), chamber volumes, cardiac output (modified Simpson's method), systolic functions (ejection fraction, pre-ejection period, ejection time and ratio) and diastolic functions( isovolumic relaxation time & deceleration time) of left and right heart. Results: Forty eight consecutive patients (mean age 65.6±11.8 yrs, 66.7% males, mean EF 61.82±10.36%) implanted a VVI pacemaker were enrolled in this study. The first significant change to appear in cardiac function after VVI pacing was in diastolic properties of RV as shown by increase in RV isovolumic relaxation time (IVRT) from 65.89±15.93 to 76.58±17.00 ms,(p<0.001) at 1week and RV deceleration time (DT) from 133.84±38.13 to 153.09±31.41 ms, (p=0.02) at 1 month. Increase in RV internal dimension (RVID) from 1.26±0.41 to 1.44±0.44, (p<0.05) was also noticed at 1 week. The LV diastolic parameters were significantly altered after 1 month with increase in LV-IVRT from 92.36±21.47 to 117.24±27.21ms, (p<0.001) and increase in LV DT from 147.56±31.84 to 189.27±28.49ms,(p<0.01). This was followed by LV systolic abnormality which appeared at 6 months with an increase in LVPEP from 100.33±14.43 to 118.41±21.34ms, (p<0.001) and increase in LVPEP/LVET ratio from 0.34±0.46 to 0.44±0.10, (p<0.001)]. The reduction in LV EF was manifested at 6 months falling from 61.82±10.36% to52.52±12.11%, (p<0.05) without any significant change in the resting cardiac output. Conclusion: The present study shows that dysfunction of right ventricle is the first abnormality that occurs in VVI paced patients, which manifests by 1 week followed by LV dysfunction which starts appearing by 1 month and the diastolic dysfunctions precede the systolic dysfunction in both ventricles

Spin-strain coupling in NiCl2-4SC(NH2)2

We report results of ultrasonic investigations of the quantum S = 1 spin-chain magnet NiCl2-4SC(NH2)2, also known as DTN, in magnetic fields up to 18 T and temperatures down to 0.3 K. A field H along the [001] direction induces a transition into an antiferromagnetic phase with T(N)max ≈ 1.2 K. Accordingly, at T = 0 there are two quantum critical points at ~2.1 T and at ~12.6 T. The acoustic c33 mode, propagating along the spin chains, shows a pronounced softening close to the phase transition, accompanied by energy dissipation of the sound wave. The H-T phase diagram obtained from our measurements is compared with results from other experimental investigations and the low-temperature acoustic anomalies are traced up to T > T(N). We also report frequency-dependent effects, which open the possibility to investigate the spin fluctuations in the critical regions. Our observations show an important role of the spin-phonon coupling in DTN