11 research outputs found
Π Π΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΠΎΠΉ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π΄Π΅Π½ΡΠΈΠ½Π°: ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ ΡΠ΅ΠΌΠΈΠ½Π΅ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΠΈ ΠΊΡΡΡΠΎΠ²ΠΎΠΌ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ Π·ΡΠ±Π½ΠΎΠΉ ΠΏΠ°ΡΡΡ Ρ ΡΡΠΎΡΠΈΠ΄ΠΎΠΌ ΠΎΠ»ΠΎΠ²Π°
The purpose of the study was clinical and laboratory analysis of the remineralizing properties and clinical efficacy of the course application of the Sensodyne Rapid Relief therapeutic and prophylactic toothpaste for sensitive teeth with tin fluoride. The study involved 50 overwise healthy patients aged from 18 to 25 years diagnosed with a localized form of hyperesthesia of hard dental tissues and no signs of acute inflammation of periodontal tissues. After 7 days of clinical observation and daily use of the toothpaste the hygienic condition of the oral cavity in all patients improved: oral hygiene index was 1.02Β±0.2 units; gum inflammation index (PMA) - 8.0Β±1.5%; the absence of hyperesthesia was diagnosed (1 point, pβ€0.05). Examination of patients after 14 and 28 days confirmed the absence of pain in 100%, the organoleptic properties of the toothpaste under investigation were also highly appreciated by the participants. A laboratory study showed that patients have an increase in the pH value of mixed saliva and a decrease in its buffer capacity by 13.4Β±2.25%, which contributes to a more effective remineralizing effect of calcium ions by calcium-binding proteins of mixed saliva. The concentration of fluoride ions in the saliva of patients of both groups increased by average rate of 34Β±0.5% per week. The combination of tin and fluoride is more effective than fluoride alone. The presence of tin ions causes a higher ability of fluorides to bind with calcium ions on the surface of the dentin and dentinal tubules, inhibits the process of demineralization, enhances the additive interaction of the ions forming the acid-resistant layer on the surface of the dentin and dentinal tubules, leading to a decrease in hyperesthesia of the teeth.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ - ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΠ΅ΠΌΠΈΠ½Π΅ΡΠ°Π»ΠΈΠ·ΡΡΡΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΡΡΡΠΎΠ²ΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π»Π΅ΡΠ΅Π±Π½ΠΎ-ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·ΡΠ±Π½ΠΎΠΉ ΠΏΠ°ΡΡΡ Sensodyne ΠΠ³Π½ΠΎΠ²Π΅Π½Π½ΡΠΉ ΠΡΡΠ΅ΠΊΡ Π΄Π»Ρ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π·ΡΠ±ΠΎΠ² Ρ ΡΡΠΎΡΠΈΠ΄ΠΎΠΌ ΠΎΠ»ΠΎΠ²Π°. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 50 ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 18 Π΄ΠΎ 25 Π»Π΅Ρ, Ρ ΠΊΠΎΡΠΎΡΡΡ
Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½Ρ Π»ΠΎΠΊΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½Π°Ρ ΡΠΎΡΠΌΠ° Π³ΠΈΠΏΠ΅ΡΠ΅ΡΡΠ΅Π·ΠΈΠΈ ΡΠ²Π΅ΡΠ΄ΡΡ
ΡΠΊΠ°Π½Π΅ΠΉ Π·ΡΠ±ΠΎΠ² ΠΈ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² ΠΎΡΡΡΠΎΠ³ΠΎ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡ ΡΠΊΠ°Π½Π΅ΠΉ ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠ°. ΠΠΎ ΠΈΡΡΠ΅ΡΠ΅Π½ΠΈΠΈ 7 Π΄Π½Π΅ΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΈ Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎΠ³ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠΉ Π·ΡΠ±Π½ΠΎΠΉ ΠΏΠ°ΡΡΡ Π³ΠΈΠ³ΠΈΠ΅Π½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΏΠΎΠ»ΠΎΡΡΠΈ ΡΡΠ° Ρ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠ»ΡΡΡΠΈΠ»ΠΎΡΡ - ΠΈΠ½Π΄Π΅ΠΊΡ Π³ΠΈΠ³ΠΈΠ΅Π½Ρ ΡΠΎΡΡΠ°Π²ΠΈΠ» 1,02Β±0,2 Π΅Π΄ΠΈΠ½ΠΈΡΡ; ΠΈΠ½Π΄Π΅ΠΊΡ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡ Π΄Π΅ΡΠ½Ρ (Π ΠΠ) - 8,0Β±1,5%; Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ Π³ΠΈΠΏΠ΅ΡΠ΅ΡΡΠ΅Π·ΠΈΠΈ (1 Π±Π°Π»Π», Ρβ€0,05). ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠ΅ΡΠ΅Π· 14 ΠΈ 28 Π΄Π½Π΅ΠΉ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ»ΠΎ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ Π±ΠΎΠ»ΠΈ Π² 100% ΡΠ»ΡΡΠ°Π΅Π², ΠΎΡΠ³Π°Π½ΠΎΠ»Π΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠΉ Π·ΡΠ±Π½ΠΎΠΉ ΠΏΠ°ΡΡΡ ΡΠ°ΠΊΠΆΠ΅ Π²ΡΡΠΎΠΊΠΎ ΠΎΡΠ΅Π½Π΅Π½Ρ ΡΡΠ°ΡΡΠ½ΠΈΠΊΠ°ΠΌΠΈ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ΅ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, ΡΡΠΎ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΡΠ ΡΠΌΠ΅ΡΠ°Π½Π½ΠΎΠΉ ΡΠ»ΡΠ½Ρ ΠΈ ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π΅Π΅ Π±ΡΡΠ΅ΡΠ½ΠΎΠΉ Π΅ΠΌΠΊΠΎΡΡΠΈ Π½Π° 13,4Β±2,25%, ΡΡΠΎ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ Π±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅ΠΌΠΈΠ½Π΅ΡΠ°Π»ΠΈΠ·ΠΈΡΡΡΡΠ΅ΠΉ ΠΎΡΠ΄Π°ΡΠ΅ ΠΈΠΎΠ½ΠΎΠ² ΠΊΠ°Π»ΡΡΠΈΡ ΠΊΠ°Π»ΡΡΠΈΠΉΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠΈΠΌΠΈ Π±Π΅Π»ΠΊΠ°ΠΌΠΈ ΡΠΌΠ΅ΡΠ°Π½Π½ΠΎΠΉ ΡΠ»ΡΠ½Ρ. ΠΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ ΠΈΠΎΠ½ΠΎΠ² ΡΡΠΎΡΠ° Π² ΡΠ»ΡΠ½Π΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏ Π·Π° 1 Π½Π΅Π΄ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅ΡΡΡ Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ Π½Π° 34Β±0,5%. Π‘ΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ ΠΎΠ»ΠΎΠ²Π° ΠΈ ΡΡΠΎΡΠΈΠ΄Π° Π±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ, ΡΠ΅ΠΌ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠΎΠ»ΡΠΊΠΎ ΡΡΠΎΡΠΈΠ΄Π°. ΠΡΠΈΡΡΡΡΡΠ²ΠΈΠ΅ ΠΈΠΎΠ½ΠΎΠ² ΠΎΠ»ΠΎΠ²Π° ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»ΠΈΠ²Π°Π΅Ρ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΡΡ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΡΡΠΎΡΠΈΠ΄ΠΎΠ² ΠΊ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ Ρ ΠΈΠΎΠ½Π°ΠΌΠΈ ΠΊΠ°Π»ΡΡΠΈΡ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ Π΄Π΅Π½ΡΠΈΠ½Π° ΠΈ Π΄Π΅Π½ΡΠΈΠ½Π½ΡΡ
ΠΊΠ°Π½Π°Π»ΡΡΠ΅Π², ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΠ΅Ρ ΠΏΡΠΎΡΠ΅ΡΡ Π΄Π΅ΠΌΠΈΠ½Π΅ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ, ΡΡΠΈΠ»ΠΈΠ²Π°Π΅Ρ Π°Π΄Π΄ΠΈΡΠΈΠ²Π½ΠΎΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΈΠΎΠ½ΠΎΠ², ΡΠΎΡΠΌΠΈΡΡΡΡΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡΠΎΡΡΡΠΎΠΉΡΠΈΠ²ΡΠΉ ΡΠ»ΠΎΠΉ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ Π΄Π΅Π½ΡΠΈΠ½Π° ΠΈ Π΄Π΅Π½ΡΠΈΠ½Π½ΡΡ
ΠΊΠ°Π½Π°Π»ΡΡΠ΅Π², ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡΠ΅Π΅ ΠΊ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π³ΠΈΠΏΠ΅ΡΠ΅ΡΡΠ΅Π·ΠΈΠΈ Π·ΡΠ±ΠΎΠ²
High prevalence of genotype B0/W148 of Mycobacterium tuberculosis among HIV-TB patients in Perm Krai and Irkutsk Region
Background. The population with HIV-infection plays significant role in ongoing tuberculosis pandemic. Immunosuppression due to HIV-infection is one of the causes of TB disseminated forms in this group of people. Having low immune status is also often associated with a polyclonal M. tuberculosis infection. Aim of the research: comparative assessment of epidemic genotypes of M. tuberculosis prevalence and mixed genotypes identification within HlV-TB co-infected patients in two Russian regions. Materials and methods. The DNAs of 78 clinical isolates from Irkutsk Region (IR) and 64 strains from Perm Krai (PK) have been genotyped by MIRU VNTR 24 and RD105/RD207. Strains were obtained from patients who did not have significant age and sex differences. In the PK age of the patients was 34.5 Β± 0.9, in IR - 34.4 Β± 1.5 years. The samples were obtained from 67.2 and 65.4 % of men, respectively. Result. The study of the M. tuberculosis indicates significant predominance of Beijing genotype strains in patients with TB-HIV of PK (92.2 %) compared to the IR (59.5 %) (Ρ
2 = 18.0; p < 0.01). The prevalence of MDR pathogens in TB-HIV patients exceeded 50 %. The mixed genotype detection in the PK and IR was high (14.1 and 12.7 % respectively). The level of virulent strains B0/W148 was 34.4 % in PK patients and 25.3 % in IR ones. Analysis of the results suggests the epidemic spread of MDR-TB in the immunocompromised individuals. Conclusions: The identified trends may indicate that Perm Kray have a process of active dissemination of transmissible strains of M. tuberculosis within HIV-infected population