Long-term deficits in cortical circuit function after asphyxial cardiac arrest and resuscitation in developing rats

AbstractCardiac arrest is a common cause of global hypoxic-ischemic brain injury. Poor neurologic outcome among cardiac arrest survivors results not only from direct cellular injury but also from subsequent long-term dysfunction of neuronal circuits. Here, we investigated the long-term impact of cardiac arrest during development on the function of cortical layer IV (L4) barrel circuits in the rat primary somatosensory cortex. We used multielectrode single-neuron recordings to examine responses of presumed excitatory L4 barrel neurons to controlled whisker stimuli in adult (8 ± 2-mo-old) rats that had undergone 9 min of asphyxial cardiac arrest and resuscitation during the third postnatal week. Results indicate that responses to deflections of the topographically appropriate principal whisker (PW) are smaller in magnitude in cardiac arrest survivors than in control rats. Responses to adjacent whisker (AW) deflections are similar in magnitude between the two groups. Because of a disproportionate decrease in PW-evoked responses, receptive fields of L4 barrel neurons are less spatially focused in cardiac arrest survivors than in control rats. In addition, spiking activity among L4 barrel neurons is more correlated in cardiac arrest survivors than in controls. Computational modeling demonstrates that experimentally observed disruptions in barrel circuit function after cardiac arrest can emerge from a balanced increase in background excitatory and inhibitory conductances in L4 neurons. Experimental and modeling data together suggest that after a hypoxic-ischemic insult, cortical sensory circuits are less responsive and less spatially tuned. Modulation of these deficits may represent a therapeutic approach to improving neurologic outcome after cardiac arrest.</jats:p

Emergence of stability in a stochastically driven pendulum: beyond the Kapitsa effect

We consider a prototypical nonlinear system which can be stabilized by multiplicative noise: an underdamped non-linear pendulum with a stochastically vibrating pivot. A numerical solution of the pertinent Fokker-Planck equation shows that the upper equilibrium point of the pendulum can become stable even when the noise is white, and the "Kapitsa pendulum" effect is not at work. The stabilization occurs in a strong-noise regime where WKB approximation does not hold.Comment: 4 pages, 7 figure

Ising Deconfinement Transition Between Feshbach-Resonant Superfluids

We investigate the phase diagram of bosons interacting via Feshbach-resonant pairing interactions in a one-dimensional lattice. Using large scale density matrix renormalization group (DMRG) and field theory techniques we explore the atomic and molecular correlations in this low-dimensional setting. We provide compelling evidence for an Ising deconfinement transition occurring between distinct superfluids and extract the Ising order parameter and correlation length of this unusual superfluid transition. This is supported by results for the entanglement entropy which reveal both the location of the transition and critical Ising degrees of freedom on the phase boundary.Comment: 4 pages, 4 figure

Itinerant ferromagnetism in an atomic Fermi gas: Influence of population imbalance

We investigate ferromagnetic ordering in an itinerant ultracold atomic Fermi gas with repulsive interactions and population imbalance. In a spatially uniform system, we show that at zero temperature the transition to the itinerant magnetic phase transforms from first to second order with increasing population imbalance. Drawing on these results, we elucidate the phases present in a trapped geometry, finding three characteristic types of behavior with changing population imbalance. Finally, we outline the potential experimental implications of the findings.Comment: 10 pages, 4 figures, typos added, references adde

Universal parametric correlations in the transmission eigenvalue spectra of disordered conductors

We study the response of the transmission eigenvalue spectrum of disordered metallic conductors to an arbitrary external perturbation. For systems without time-reversal symmetry we find an exact non-perturbative solution for the two-point correlation function, which exhibits a new kind of universal behavior characteristic of disordered conductors. Systems with orthogonal and symplectic symmetries are studied in the hydrodynamic regime.Comment: 10 pages, written in plain TeX, Preprint OUTP-93-36S (University of Oxford), to appear in Phys. Rev. B (Rapid Communication

Experimental characterization of vertical-axis wind turbine noise.

Vertical-axis wind turbines are wind-energy generators suitable for use in urban environments. Their associated noise thus needs to be characterized and understood. As a first step, this work investigates the relative importance of harmonic and broadband contributions via model-scale wind-tunnel experiments. Cross-spectra from a pair of flush-mounted wall microphones exhibit both components, but further analysis shows that the broadband dominates at frequencies corresponding to the audible range in full-scale operation. This observation has detrimental implications for noise-prediction reliability and hence also for acoustic design optimization.The first author thanks the UK Engineering and Physical Sciences Research Council for a Doctoral Training Grant.This is the final published version. It first appeared at http://scitation.aip.org/content/asa/journal/jasa/137/1/10.1121/1.4904915

Use of a mass spectrometer to determine the composition of the undisturbed Martian atmosphere from a hypersonic entry vehicle Final report

Mass spectrometer aboard hypersonic entry vehicle for chemical composition study of Martian atmospher

A Brownian Motion Model of Parametric Correlations in Ballistic Cavities

A Brownian motion model is proposed to study parametric correlations in the transmission eigenvalues of open ballistic cavities. We find interesting universal properties when the eigenvalues are rescaled at the hard edge of the spectrum. We derive a formula for the power spectrum of the fluctuations of transport observables as a response to an external adiabatic perturbation. Our formula correctly recovers the Lorentzian-squared behaviour obtained by semiclassical approaches for the correlation function of conductance fluctuations.Comment: 19 pages, written in RevTe