BES with FEM: Building Energy Simulation using Finite Element Methods

An overall objective of energy efficiency in the built environment is to improve building and systems performances in terms of durability, comfort and economics. In order to predict, improve and meet a certain set of performance requirements related to the indoor climate of buildings and the associated energy demand, building energy simulation (BES) tools are indispensable. Due to the rapid development of FEM software and the Multiphysics approaches, it should possible to build and simulate full 3D models of buildings regarding the energy demand. The paper presents a methodology for performing building energy simulation with Comsol. The method was applied to an international test box experiment. The results showed an almost perfect agreement between the used BES model and Comsol. These preliminary results confirm the great opportunities to use FEM related software for building energy performance simulation.Comment: 5 pages, 6 figures, Proceedings of the 2012 COMSOL Conference in Mila

Purification and quantification of recombinant Epstein-Barr viral glycoproteins gp350/220 from Chinese hamster ovary cells

Truncated Epstein-Barr virus (EBV) membrane antigen gp350/220 (EBV-MA) lacking the membrane anchor was expressed and secreted into the medium of recombinant Chinese hamster ovary cells that had been cultured in Plasmapur hollow-fibre modules using defined serum-free medium. The EBV-MA in the medium was concentrated by 70% (w/v) ammonium sulphate precipitation and subsequently purified by immunoaffinity chromatography using an anti-EBV-MA (EBV.0T6) monoclonal antibody (mAb) column. Adsorbed antigen was eluted with 3 M MgCl2 in phosphate-buffered saline, concentrated by Mono Q anion-exchange chromatography and analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis, silver staining and Western blotting using EBV-positive serum and anti-EBV-MA specific mAbs. Monospecific polyclonal rabbit antibodies against the purified EBV-MA were raised and purified by protein G affinity chromatography. For the measurement of EBV-MA antigen levels a sandwich enzyme-linked immunosorbent assay using rabbit polyclonal antibodies and a horseradish peroxidase-conjugated anti-MA mAb was developed having a detection level of 10 ng/ml

Application of system identification methods to implement Comsol models into external simulation environments

Full coupling of distributed parameter models, like Comsol, with the lumped models often lead to very time-consuming simulation duration times. In order to improve the speed of the simulations, the idea of using system identification methods to implement the distributed parameters models of Comsol into external simulation environments (SimuLink), is explored. It is concluded that the system identification methods are a valuable tool for such applications, and result in models that not only are easy and fast to derive using the appropriate tools (SI Toolbox of Matlab), but also in models with a very satisfactory performance that offer great reduction of the simulation times

Levensbeschouwing op school mist status

Volgens Expertisecentrum Lervo is er dringend behoefte aan een leerplan voor het vak levensbeschouwing en religie op middelbare scholen. ‘De school moet kinderen klaarmaken voor de superdiverse samenleving.’Religious Studie

Comsol Simulations of Cracking in Point Loaded Masonry with Randomly Distributed Material Properties

This paper describes COMSOL simulations of the stress and crack development in the area where a masonry wall supports a floor. In these simulations one of the main material properties of calcium silicate, its E-value, was assigned randomly to the finite elements of the modeled specimen. Calcium silicate is a frequently used building material with a relatively brittle fracture characteristic. Its initial E-value varies, as well as tensile strength and post peak behavior. Therefore, in the simulation, initial E-values were randomly assigned to the elements of the model and a step function used for describing the descending branch. The method also allows for variation in strength to be taken into account in future research. The performed non-linear simulation results are compared with experimental findings. They show the stress distribution and cracking behavior in point loaded masonry when varying material properties are used.Comment: Conference pape

The multiphysics modeling of heat and moisture induced stress and strain of historic building materials and artefacts

The basic structure of historic sites and their associated interior artefacts can be damaged or even destroyed by climate change. The evaluation of combined heat and moisture induced stress and strain (HMSS) can predict possible damage-related processes. In this paper, the development of one- and two-dimensional HMSS models of building materials and artefacts in COMSOL Multiphysics Version 4, a commercial finite element software, is presented. The validation of the numerical models is revealed using analytical, numerical and experimental solutions. As a result, the HMSS model was shown to be an adequate predictive tool to determine possible damage-related processes in building assemblies and artefacts

Implementation of a group-based physical activity programme for ageing adults with ID: A process evaluation

Rationale, aim and objectives This paper describes the results of the process evaluation of a physical activity programme for people with intellectual disabilities (ID), including information about the concepts 'fidelity', 'dose delivered', 'satisfaction' and 'context'. Methods Qualitative and quantitative methods among participants and programme leaders were used. Results The programme was well accepted, feasible and applicable to ageing people with ID. It was successfully implemented in terms of fidelity and dose delivered, although differences between day-activity centres were observed. Conclusions The hampering factors that are revealed in this study and the facilitating activities that were part of the implementation plan may be used by care provider services for (ageing) people with ID and other groups of people with cognitive and/or physical deficits, such as frail elderly people or people with dementia when developing and or preparing implementation of health promotion programmes

Spinal cord atrophy in a primary progressive multiple sclerosis trial: Improved sample size using GBSI

Background: We aimed to evaluate the implications for clinical trial design of the generalised boundary-shift integral (GBSI) for spinal cord atrophy measurement. / Methods: We included 220 primary-progressive multiple sclerosis patients from a phase 2 clinical trial, with baseline and week-48 3DT1-weighted MRI of the brain and spinal cord (1 × 1 × 1 mm3), acquired separately. We obtained segmentation-based cross-sectional spinal cord area (CSA) at C1-2 (from both brain and spinal cord MRI) and C2-5 levels (from spinal cord MRI) using DeepSeg, and, then, we computed corresponding GBSI. / Results: Depending on the spinal cord segment, we included 67.4–98.1% patients for CSA measurements, and 66.9–84.2% for GBSI. Spinal cord atrophy measurements obtained with GBSI had lower measurement variability, than corresponding CSA. Looking at the image noise floor, the lowest median standard deviation of the MRI signal within the cerebrospinal fluid surrounding the spinal cord was found on brain MRI at the C1-2 level. Spinal cord atrophy derived from brain MRI was related to the corresponding measures from dedicated spinal cord MRI, more strongly for GBSI than CSA. Spinal cord atrophy measurements using GBSI, but not CSA, were associated with upper and lower limb motor progression. / Discussion: Notwithstanding the reduced measurement variability, the clinical correlates, and the possibility of using brain acquisitions, spinal cord atrophy using GBSI should remain a secondary outcome measure in MS studies, until further advancements increase the quality of acquisition and reliability of processing