2 research outputs found
ΠΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΡ ΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ· Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² Π² ΠΎΡΠ²Π΅Ρ Π½Π° ΡΡΠΈΠΌΡΠ»ΡΡΠΈΡ Π±ΠΎΡΡΠ΅Π»ΠΈΠΎΠ·Π½ΡΠΌ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠΌ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ ΠΈΠΊΡΠΎΠ΄ΠΎΠ²ΡΠΌ ΠΊΠ»Π΅ΡΠ΅Π²ΡΠΌ Π±ΠΎΡΡΠ΅Π»ΠΈΠΎΠ·ΠΎΠΌ
The object of this work was to study the correlation between the lymphocyte proliferation and apoptosis in the cultures stimulated by specific inactivated Borrelia garinii antigen and the different clinical outcomes in Lyme borreliosis patients. It was found that borrelia antigen stimulation of the cultures obtained from chronic patients induced T helper type 1-like response as well as depression in lymphocyte apoptosis, which may provide the basis of persistent activated T cell immune response and chronic inflammatory in Lyme borreliosis.Π¦Π΅Π»Ρ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ Π·Π°ΠΊΠ»ΡΡΠ°Π»Π°ΡΡ Π² ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌΠΈ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠΈ ΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΠΊΡΠ»ΡΡΡΡΠ°Ρ
Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ², ΡΡΠΈΠΌΡΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΌ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠΌ B. garinii, ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡ
ΠΎΠ΄ΠΎΠ² Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΠΊΡΠΎΠ΄ΠΎΠ²ΡΠΌ ΠΊΠ»Π΅ΡΠ΅Π²ΡΠΌ Π±ΠΎΡΡΠ΅Π»ΠΈΠΎΠ·ΠΎΠΌ (ΠΠΠ). Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΡ Π±ΠΎΡΡΠ΅Π»ΠΈΠΎΠ·Π½ΡΠΌ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠΌ ΠΊΡΠ»ΡΡΡΡ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΎΡ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΠΠ, ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ in vitro Π’-Ρ
Π΅Π»ΠΏΠ΅ΡΠΎΠ² ΡΠΈΠΏΠ° 1 ΠΏΡΠΈ ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ, ΡΡΠΎ ΠΌΠΎΠΆΠ΅Ρ Π»Π΅ΠΆΠ°ΡΡ Π² ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠ΅ΡΡΠΈΡΡΠ΅Π½ΡΠ½ΠΎ Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π’-ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° ΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΏΡΠΈ ΡΡΠΎΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΈ
Proliferation and apoptosis of lymphocytes in response to borrelia antigen stimulation in Lyme-borreliosis patients
The object of this work was to study the correlation between the lymphocyte proliferation and apoptosis in the cultures stimulated by specific inactivated Borrelia garinii antigen and the different clinical outcomes in Lyme borreliosis patients. It was found that borrelia antigen stimulation of the cultures obtained from chronic patients induced T helper type 1-like response as well as depression in lymphocyte apoptosis, which may provide the basis of persistent activated T cell immune response and chronic inflammatory in Lyme borreliosis