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Assembly Of The First Dwarf Galaxies
Understanding the formation and evolution of the first stars and galaxies is crucial to understanding reionization, a key epoch in the history of the Universe. Detailed theoretical studies of the galaxies before and during reionization are now particularly urgent because of the wealth of observational data that will soon be provided by the next generation of telescopes, such as JWST, ALMA, LOFAR, MWA, and others. We simulate the formation of the first galaxies using cosmological smoothed particle hydrodynamics simulations. Zooming in on individual galaxies, we explore how various physical processes affect their assembly and further evolution. A highlight of our study will be the simulation of the radiation-hydrodynamics of galaxy assembly, which we will perform using our multi-frequency radiative transfer method TRAPHIC. Feedback from radiation has long been suspected to play a decisive role in galaxy formation and we will investigate its implications for observable properties of the first galaxies.Astronom
Black Hole Feedback On The First Galaxies
We study how the first galaxies were assembled under feedback from the accretion onto a central black hole (BH) that is left behind by the first generation of metal-free stars through self-consistent, cosmological simulations. X-ray radiation from the accretion of gas onto BH remnants of Population III (Pop III) stars, or from high-mass X-ray binaries (HMXBs), again involving Pop III stars, influences the mode of second generation star formation. We track the evolution of the black hole accretion rate and the associated X-ray feedback starting with the death of the Pop III progenitor star inside a minihalo and following the subsequent evolution of the black hole as the minihalo grows to become an atomically cooling galaxy. We find that X-ray photoionization heating from a stellar-mass BH is able to quench further star formation in the host halo at all times before the halo enters the atomic cooling phase. X-ray radiation from a HMXB, assuming a luminosity close to the Eddington value, exerts an even stronger, and more diverse, feedback on star formation. It photoheats the gas inside the host halo, but also promotes the formation of molecular hydrogen and cooling of gas in the intergalactic medium and in nearby minihalos, leading to a net increase in the number of stars formed at early times. Our simulations further show that the radiative feedback from the first BHs may strongly suppress early BH growth, thus constraining models for the formation of supermassive BHs.Astronom
Can short-term preconditioning with lemon balm extract protect the heart from I/R injury? : [abstract]
Co-overexpression of bcl-2 and c-myc in uterine cervix carcinomas and premalignant lesions
To establish the role of co-overexpression of bcl-2 and c-myc protooncogenes in uterine cervix carcinogenesis, we examined 138 tissue samples of low grade cervical squamous intraepithelial lesions (SIL), high grade SIL, portio vaginalis uteri (PVU) carcinoma in situ and PVU invasive carcinoma, stage IA-IIA (study group) and 36 samples without SIL or malignancy (control group). The expression of bcl-2 and c-myc was detected immunohistochemically using a monoclonal antibody. Fisher's exact test (P<0.05) was used to assess statistical significance. Overexpression of bcl-2 was found to increase in direct relation to the grade of the cervical lesions. High sensitivity was of great diagnostic significance for the detection of these types of changes in the uterine cervix. On the basis of high predictive values it can be said that in patients with bcl-2 overexpression there is a great possibility that they have premalignant or malignant changes in the uterine cervix. Co-overexpression of bcl-2 and c-myc oncogenes was found only in patients with PVU invasive carcinoma (6/26-23.0%). Statistically significant difference was not found in the frequency of co-overexpression in patients with PVU invasive carcinoma in relation to the control group (Fisher's test; P=0.064). The method's sensitivity of determining these oncogenes with the aim of detecting PVU invasive carcinoma was 23%, while specificity was 72.2%. On the basis of high predictive values (100%), speaking in statistical terms, it can be concluded that all patients with co-overexpression of bcl-2 and c-myc oncogenes will have PVU invasive carcinoma. We confirmed in our research that co-overexpression of bcl-2 and c-myc oncogenes was increased only in PVU invasive carcinoma. However, a more extensive series of samples and additional tests are required to establish the prognostic significance of bcl-2 and c-myc co-overexpression in cervical carcinogenesis
Pyrrolizidine alkaloids from seven wild-growing Senecio species in Serbia and Montenegro
The genus Senecio (family Asteraceae) is one of the largest in the world. It comprises about 1100 species which are the rich source of pyrrolizidine alkaloids. Plants containing pyrrolizidine alkaloids are among the most important sources of human and animal exposure to plant toxins and carcinogens. The pyrrolizidine alkaloids of seven Senecio species (S. erucifolius, S. othonnae, S. wagneri, S. subalpinus, S. carpathicus, S. paludosus and S. rupestris) were studied. Fourteen alkaloids were isolated and their structures determined from spectroscopic data (1H- and 13C-NMR, IR and MS). Five of them were identified in S. erucifolius, four in S. othonnae, two in S. wagneri, four in S. subalpinus, two in S. carpathicus, three in S. paludosus and three in S. rupestris. Seven pyrrolizidine alkaloids were found for the first time in particular species. The results have chemotaxonomic importance. The cytotoxic activity and antimicrobial activity of some alkaloids were also studied
Direct Formation of Supermassive Black Holes via Multi-Scale Gas Inflows in Galaxy Mergers
Observations of distant bright quasars suggest that billion solar mass
supermassive black holes (SMBHs) were already in place less than a billion
years after the Big Bang. Models in which light black hole seeds form by the
collapse of primordial metal-free stars cannot explain their rapid appearance
due to inefficient gas accretion. Alternatively, these black holes may form by
direct collapse of gas at the center of protogalaxies. However, this requires
metal-free gas that does not cool efficiently and thus is not turned into
stars, in contrast with the rapid metal enrichment of protogalaxies. Here we
use a numerical simulation to show that mergers between massive protogalaxies
naturally produce the required central gas accumulation with no need to
suppress star formation. Merger-driven gas inflows produce an unstable, massive
nuclear gas disk. Within the disk a second gas inflow accumulates more than 100
million solar masses of gas in a sub-parsec scale cloud in one hundred thousand
years. The cloud undergoes gravitational collapse, which eventually leads to
the formation of a massive black hole. The black hole can grow to a billion
solar masses in less than a billion years by accreting gas from the surrounding
disk.Comment: 26 pages, 4 Figures, submitted to Nature (includes Supplementary
Information
Evolution of supermassive black holes
Supermassive black holes (SMBHs) are nowadays believed to reside in most
local galaxies, and the available data show an empirical correlation between
bulge luminosity - or stellar velocity dispersion - and black hole mass,
suggesting a single mechanism for assembling black holes and forming spheroids
in galaxy halos. The evidence is therefore in favour of a co-evolution between
galaxies, black holes and quasars. In cold dark matter cosmogonies, small-mass
subgalactic systems form first to merge later into larger and larger
structures. In this paradigm galaxy halos experience multiple mergers during
their lifetime. If every galaxy with a bulge hosts a SMBH in its center, and a
local galaxy has been made up by multiple mergers, then a black hole binary is
a natural evolutionary stage. The evolution of the supermassive black hole
population clearly has to be investigated taking into account both the
cosmological framework and the dynamical evolution of SMBHs and their hosts.
The seeds of SMBHs have to be looked for in the early Universe, as very
luminous quasars are detected up to redshift higher than z=6. These black holes
evolve then in a hierarchical fashion, following the merger hierarchy of their
host halos. Accretion of gas, traced by quasar activity, plays a fundamental
role in determining the two parameters defining a black hole: mass and spin. A
particularly intriguing epoch is the initial phase of SMBH growth. It is very
challenging to meet the observational constraints at z=6 if BHs are not fed at
very high rates in their infancy.Comment: Extended version of the invited paper to appear in the Proceedings of
the Conference "Relativistic Astrophysics and Cosmology - Einstein's Legacy
Two photon annihilation of Kaluza-Klein dark matter
We investigate the fermionic one-loop cross section for the two photon
annihilation of Kaluza-Klein (KK) dark matter particles in a model of universal
extra dimensions (UED). This process gives a nearly mono-energetic gamma-ray
line with energy equal to the KK dark matter particle mass. We find that the
cross section is large enough that if a continuum signature is detected, the
energy distribution of gamma-rays should end at the particle mass with a peak
that is visible for an energy resolution of the detector at the percent level.
This would give an unmistakable signature of a dark matter origin of the
gamma-rays, and a unique determination of the dark matter particle mass, which
in the case studied should be around 800 GeV. Unlike the situation for
supersymmetric models where the two-gamma peak may or may not be visible
depending on parameters, this feature seems to be quite robust in UED models,
and should be similar in other models where annihilation into fermions is not
helicity suppressed. The observability of the signal still depends on largely
unknown astrophysical parameters related to the structure of the dark matter
halo. If the dark matter near the galactic center is adiabatically contracted
by the central star cluster, or if the dark matter halo has substructure
surviving tidal effects, prospects for detection look promising.Comment: 17 pages, 3 figures; slightly revised versio
Raman scattering analysis of silicon dioxide single crystal treated by direct current plasma discharge
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