96 research outputs found
MODELING OF THE CHEMICAL STAGE OF RADIOBIOLOGICAL MECHANISM USING PETRI NETS
The biological effect of ionizing particles is caused mainly by water radicals being formed by densely ionizing ends of primary or secondary charged particles during physical stage; only greater radical clusters being efficient in DNA molecule damaging. The given clusters diffuse after their formation and the radical concentration changes also by reactions running mutually or with other substances being present in corresponding clusters. The damage effect depends then on radical concentrations at a time when the cluster meets a DNA molecule. The influence of oxygen may be important (mainly in the case of low-LET radiation) because oxygen is always present in living cells. Oxygen may act then in two different directions: at small concentrations the interaction with hydrogen radicals prevails and final biological effect diminishes while at higher concentrations additional efficient oxygen radicals may be formed. The time evolution of changing radical concentrations during cluster diffusion may be modeled and analyzed well with the help of Continuous Petri nets
Three-dimensional harmonic oscillator and time evolution in quantum mechanics
The problem of defining time (or phase) operator for three-dimensional
harmonic oscillator has been analyzed. A new formula for this operator has been
derived. The results have been used to demonstrate a possibility of
representing quantum-mechanical time evolution in the framework of an extended
Hilbert space structure. Physical interpretation of the extended structure has
been discussed shortly, too.Comment: 14 pages; submitted to Phys Rev
Detailed analysis of the cell-inactivation mechanism by accelerated protons and light ions
Published survival data for V79 cells irradiated by monoenergetic protons,
helium-3, carbon, and oxygen ions and for CHO cells irradiated by carbon ions
have been analyzed using the probabilistic two-stage model of cell
inactivation. Three different classes of DNA damages formed by traversing
particles have been distinguished, namely severe single-track damages which
might lead to cell inactivation directly, less severe damages where cell
inactivation is caused by their combinations, and damages of negligible
severity that can be repaired easily. Probabilities of single ions to form
these damages have been assessed in dependence on their linear energy transfer
(LET) values.
Damage induction probabilities increase with atomic number and LET. While
combined damages play crucial role at lower LET values, single-track damages
dominate in high-LET regions. The yields of single-track lethal damages for
protons have been compared with the Monte Carlo estimates of complex DNA
lesions, indicating that lethal events correlate well with complex DNA
double-strand breaks. The decrease in the single-track damage probability for
protons of LET above approx. 30 keV/m, suggested by limited experimental
evidence, is discussed, together with the consequent differences in the
mechanisms of biological effects between protons and heavier ions. Applications
of the results in hadrontherapy treatment planning are outlined.Comment: submitted to Physics in Medicine and Biolog
LHC Optics Measurement with Proton Tracks Detected by the Roman Pots of the TOTEM Experiment
Precise knowledge of the beam optics at the LHC is crucial to fulfil the
physics goals of the TOTEM experiment, where the kinematics of the scattered
protons is reconstructed with the near-beam telescopes -- so-called Roman Pots
(RP). Before being detected, the protons' trajectories are influenced by the
magnetic fields of the accelerator lattice. Thus precise understanding of the
proton transport is of key importance for the experiment. A novel method of
optics evaluation is proposed which exploits kinematical distributions of
elastically scattered protons observed in the RPs. Theoretical predictions, as
well as Monte Carlo studies, show that the residual uncertainty of this optics
estimation method is smaller than 0.25 percent.Comment: 20 pages, 11 figures, 5 figures, to be submitted to New J. Phy
Diamond Detectors for the TOTEM Timing Upgrade
This paper describes the design and the performance of the timing detector
developed by the TOTEM Collaboration for the Roman Pots (RPs) to measure the
Time-Of-Flight (TOF) of the protons produced in central diffractive
interactions at the LHC. The measurement of the TOF of the protons allows the
determination of the longitudinal position of the proton interaction vertex and
its association with one of the vertices reconstructed by the CMS detectors.
The TOF detector is based on single crystal Chemical Vapor Deposition (scCVD)
diamond plates and is designed to measure the protons TOF with about 50 ps time
precision. This upgrade to the TOTEM apparatus will be used in the LHC run 2
and will tag the central diffractive events up to an interaction pileup of
about 1. A dedicated fast and low noise electronics for the signal
amplification has been developed. The digitization of the diamond signal is
performed by sampling the waveform. After introducing the physics studies that
will most profit from the addition of these new detectors, we discuss in detail
the optimization and the performance of the first TOF detector installed in the
LHC in November 2015.Comment: 26 pages, 18 figures, 2 tables, submitted for publication to JINS
Double diffractive cross-section measurement in the forward region at LHC
The first double diffractive cross-section measurement in the very forward
region has been carried out by the TOTEM experiment at the LHC with
center-of-mass energy of sqrt(s)=7 TeV. By utilizing the very forward TOTEM
tracking detectors T1 and T2, which extend up to |eta|=6.5, a clean sample of
double diffractive pp events was extracted. From these events, we measured the
cross-section sigma_DD =(116 +- 25) mub for events where both diffractive
systems have 4.7 <|eta|_min < 6.5 .Comment: 5 pages, 1 figure, submitted for publicatio
Performance of the TOTEM Detectors at the LHC
The TOTEM Experiment is designed to measure the total proton-proton
cross-section with the luminosity-independent method and to study elastic and
diffractive pp scattering at the LHC. To achieve optimum forward coverage for
charged particles emitted by the pp collisions in the interaction point IP5,
two tracking telescopes, T1 and T2, are installed on each side of the IP in the
pseudorapidity region 3.1 < = |eta | < = 6.5, and special movable beam-pipe
insertions - called Roman Pots (RP) - are placed at distances of +- 147 m and
+- 220 m from IP5. This article describes in detail the working of the TOTEM
detector to produce physics results in the first three years of operation and
data taking at the LHC.Comment: 40 pages, 31 figures, submitted to Int. J. Mod. Phys.
Proton-proton elastic scattering at the LHC energy of {\surd} = 7 TeV
Proton-proton elastic scattering has been measured by the TOTEM experiment at
the CERN Large Hadron Collider at {\surd}s = 7 TeV in dedicated runs with the
Roman Pot detectors placed as close as seven times the transverse beam size
(sbeam) from the outgoing beams. After careful study of the accelerator optics
and the detector alignment, |t|, the square of four-momentum transferred in the
elastic scattering process, has been determined with an uncertainty of d t =
0.1GeV p|t|. In this letter, first results of the differential cross section
are presented covering a |t|-range from 0.36 to 2.5GeV2. The differential
cross-section in the range 0.36 < |t| < 0.47 GeV2 is described by an
exponential with a slope parameter B = (23.6{\pm}0.5stat {\pm}0.4syst)GeV-2,
followed by a significant diffractive minimum at |t| =
(0.53{\pm}0.01stat{\pm}0.01syst)GeV2. For |t|-values larger than ~ 1.5GeV2, the
cross-section exhibits a power law behaviour with an exponent of -7.8_\pm}
0.3stat{\pm}0.1syst. When compared to predictions based on the different
available models, the data show a strong discriminative power despite the small
t-range covered.Comment: 12pages, 5 figures, CERN preprin
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