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    ОЦЕНКА ЭФФЕКТИВНОСТИ И БЕЗОПАСНОСТИ ПЕРОРАЛЬНЫХ АНТИКОАГУЛЯНТОВ У ПАЦИЕНТОВ С ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ В ПРОСПЕКТИВНОМ НАБЛЮДЕНИИ

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    PURPOSE. To evaluate the effectiveness and safety of warfarin therapy using a clinical laboratory model of centralized monitoring of international normalized relationships, and direct oral anticoagulants in patients with atrial fibrillation in real clinical practice.MATERIAL AND METHODS. In a non-interactive prospective study, 661 atrial fibrillation patients were prescribed oral anticoagulants to prevent cardioembolic complications. The study included patients older than 18 years of age, with creatinine clearance at least 50 ml/min. Рatients were divided into 4 groups: 1 group of 120 people who took warfarin was observed in the conditions of centralized monitoring the international normalized ratio (INR), group 2 – 112 people– was taking Rivaroxaban, group 3 – 106 people– was taking Dabigatran, group 4 – 98 people took Apixaban. Formed 4 groups of patients were comparable in age, concomitant diseases, risks of thromboembolic and hemorrhagic complications.The follow-up period was 2 years from the date of prescribing.RESULTS. In patients who were observed in the clinical laboratory model of centralized monitoring of INR, the TTR was 69.4%. The groups did not differ in the number of thromboembolic complications (p>0.05). Warfarin had an advantage in the amount of large bleeding - 0.9% versus 3.6% taking rivaroxaban and 3.8% taking dabigatran (p = 0.044 and p = 0.035, respectively) without statistical significance for apixaban.CONCLUSION. The ratio of efficacy and safety of warfarin therapy can be successfully maintained at a satisfactory level using a centralized monitoring system of international normalized relationships. It allows you to get comparable treatment results with warfarin and direct inhibitors of blood coagulation factors in real clinical practice.ЦЕЛЬ. Оценить эффективность и безопасность терапии варфарином при использовании клинико-лабораторной модели централизованного мониторинга международного нормализованного отношения и прямыми оральными антикоагулянтами у пациентов с фибрилляцией предсердий в условиях реальной клинической практики.МАТЕРИАЛ И МЕТОДЫ. В ходе неинтервенционного проспективного исследования наблюдались 661 пациент с фибрилляцией предсердий старше 18 лет и с клиренсом креатинина не менее 50 мл/мин, получавшие варфарин (n = 120), ривароксабан (n = 112), дабигатран (n = 106) и апиксабан (n = 98). Пациенты, принимавшие варфарин, наблюдались в условиях централизованного мониторинга международного нормализованного отношения (МНО). Сформированные четыре группы пациентов были сопоставимы по возрасту, сопутствующим заболеваниям, рискам тромбоэмболических и геморрагических осложнений. Срок наблюдения составил 2 года от момента назначения препарата. В качестве конечных точек наблюдения рассматривали тромбоэмболические осложнения (ТЭО), большие кровотечения и смерть по любой причине.РЕЗУЛЬТАТЫ. В ходе наблюдения и использования клинико-лабораторной модели централизованного мониторинга МНО для варфарина достигнуто среднее время нахождения пациентов в терапевтическом целевом интервале 69,4%. Сравнение клинических результатов не показало статистически значимых отличий в исследованных группах по частоте ТЭО и некоторое преимущество в группе принимающих варфарин по количеству больших кровотечений – 0,9% против 3,6% принимающих ривароксабан и 3,8% принимающих дабигатран (р = 0,044 и р = 0,035 соответственно) без статистической значимости для апиксабана.ВЫВОД. Соотношение эффективности и безопасности терапии варфарином может с успехом поддерживаться на удовлетворительном уровне с помощью системы централизованного мониторинга международного нормализованного отношения, которая позволяет получать сопоставимые результаты лечения варфарином и прямыми ингибиторами факторов свертывания крови в реальной клинической практике

    X-band coaxial monopole antenna with an additional metal screen

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    The novel coaxial monopole antenna design with an additional metal screen is presented. The radiation char- acteristics of this antenna are investigated depending on a dis- tance between the ground plane and additional metal screens, as well as on a size of the latter. Measured and calculated ra- diation patterns are compared within limits of the operative frequency band and their revealed distinctions are discussed. The antennas characteristics allow pronounce that it can be considered as a promising candidate for various practical ap- plications both a single radiator and a composite element of antenna arrays

    The antenna system of the compact nonlinear locator for the wide application

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    Two printed antennas (f<sub>1</sub> = 1.85 GHz; f<sub>2</sub> = 3.7 GHz) made in the same form factor for the nonlinear locator has been determined. The first tests of antennas in a network of the nonlinear locator showed the ability to detect a variety of radio-electronic devices

    Trochantric severity score a useful tool to assess outcomes after intertrochantric fractures

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    INTRODUCTION: Intertrochanteric fractures (ITF) are of intense interest globally. These fractures are most frequently operated type having the highest postoperative fatality rates and hence have become a serious health resource issue. AIM: The aim of this study is to assess the risk factors and their effect on the outcome of intertrochanteric fractures treated by sliding hip screw fixation. SETTINGS AND DESIGN: This is a retrospective and prospective observational study of all the intertrochanteric fractures treated by sliding hip screw fixation at our institute between January 2013 to August 2015. MATERIALS AND METHODS: A total of 78 intertrochanteric fractures have met the inclusion criteria proposed for the study. Preoperative and intraoperative risk factors were assessed for all the cases and treated by sliding hip screw. The Radiological outcome was assessed after a minimum follow-up of 3 months for all the cases. RESULTS: When comparing all the preoperative and intraoperative variables independently with the outcome, P value was found to be statistically significant only in displacement, reverse obliquity, inadequate lateral wall thickness, and reduction. We devised a scoring system to assess the risk outcome in the treatment of trochanteric fractures based on local fracture factors. Least score of zero and a maximum score of eight was seen in the study participants. CONCLUSION: Trochantric severity score is a useful tool to assess the outcome of management of intertrochanteric fractures. Sliding hip screw may not be an ideal implant for, trochantric fractures with inadequate lateral wall thickness (failure rate of 63%), reverse oblique type of trochanter fractures (failure rates of 50%), and displaced comminuted fractures (failure rate of 13%)
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