Assessment of the DNA damage level in peripheral blood leukocytes of mice treated orally with Rapitalam in acute and therapeutic doses

Centre there was performed experimental research, which carried out the identification and quantitative assessment of alkali-labile sites and DNA strand breaks in leukocytes of peripheral blood of male mice treated with Rapitalam. The method is based on the assessment of the integrity of DNA in leukocytes of the whole blood of animals. Rapitalam was administered to animals orally according to 2 schemes: a single acute dose (413 mg/kg, which corresponds to 1/5 LD50 dose) and once daily in a therapeutic dose (3 mg/kg) for 4 day

Pharmacokinetic studies of new antiparkinsonian drug Rapitalam

The aim of this study was to investigate the pharmacokinetic parameters of the mGluR4 receptor blocker Rapitalam on rabbits. There was developed the method of the quantitative determination of Rapitalam in the blood plasma of rabbits using high performance liquid chromatography with tandem mass spectrometric detection. The study was performed on 12 rabbits (males, weighing between 3,300 to 3,500 g). In intragastric dosing of the substance was administered using a gastric tube in the form of suspension in water 0.9 mg/ml, 9 mg/ml, and 90 mg/ml at a dose of 0.3 mg/kg, 3 mg/kg and 30 mg/kg. The main pharmacokinetic parameters of the substance was established on rabbits that allow you to optimize the future use of it's as a potential drug for the treatment of Parkinson's diseas

The definition of specific antiparkinsonian effects of Rapitalam

Previously, we identified a metabotropic glutamate receptor 4 (mGluR4) as a potential target for drugs and predicted that activation of mGluR4 could provide a palliative advantage in the treatment of Parkinson's disease. Determine the mechanism of action of Rapitalam in vitro on a cell culture with mGluR4 over expression. The HEK293T cell line expressing human mGluR4 was used in the wor

Social and psychological adaptation features of newly appointed managers

In the professional environment, socio-psychological adaptation to work occurs among workers, ordinary specialists and managers. The adaptation process is the most difficult for employees appointed to a managerial position for the first time. This is because they need not only to adapt to a new job, but also to choose a suitable management strategy, as well as to meet the expectations of subordinates and match their level. They should have such managerial skills to set correctly tasks taking into account the professional level of subordinates and their socio-psychological characteristics. The authors of the article consider the main problems faced by first-time managers during the socio-psychological adaptation to professional activity. The study presents the most effective mechanisms and tools that will make the adaptation of such employees as successful as possible

Socio-psychological adaptation in the context of the trend of transition to a remote work format

Digital technologies have become firmly embedded in all spheres of our life. Presently, it is almost impossible to imagine a single day without the use of gadgets and electronic devices. An important place in the modern world is occupied by the problem of socio-psychological adaptation, which takes place in the process of digitalization. Managers pay attention to the adaptation process of new employees, but they do not always take into account that the transition to a remote format of work for most employees can cause a stressful state. Therefore, it is so important to organize comfortable conditions during the adaptation period to new working conditions. The article considers the socio-psychological features that allow them to pass most effectively the adaptation period in the conditions of the tendency to switch to a remote format of work. The most distinctive characteristics are highlighted, in which the adaptation is as successful as possible

THE SPECIFICITY OF THE PROFESSIONAL ADAPTATION OF THE MANAGERIAL STAFF OF DIFFERENT GENERATIONS

The problem of adaptation to professional activity among representatives of different generations is acute. Currently, managers understand the need and importance of the adaptation process for new employees. But they do not always take into account the fact that employees belonging to different generations may not only have radically different views on the same problems, but also the process of adaptation may take place in different ways, using different socio-psychological mechanisms of adaptation. Using the example of generation X and generation Y the psychological features that make it possible to pass the adaptation period most effectively have been considered in the article. The most distinctive characteristics of representatives of different generations have been highlighted

The application of lean technologies to optimize oncological screening in the periodic health examination of adult population groups

Background. Improving organizational technologies for early detection of cancer using targeted programs for large-scale cancer screening is a priority task of primary health care.The aim: to assess the potential of lean technologies to optimize cancer screening during periodic health examination of the adult population.Materials and methods. To develop an optimal organizational and functional model of cancer screening, a working group was created; information about the current state of the process was collected.Results. A comprehensive analysis of the state of the process revealed the following problems: violation of the algorithms of oncological screening at stage 1 of periodic health examination (13.8 %); cases of non-completion of stage 2 of periodic health examination by patients with suspected colon cancer (20.4 %); queues for endoscopic examinations (14 days) and, as a consequence, not a quick visit to the oncologist of the primary oncology department (17–18 days). After optimization of the periodic health examination: there is no queue for endoscopy for patients with suspected oncopathology; accelerated access of patients with suspected oncopathology to the oncologist of the primary oncology department (from 17–18 to 5 days; p < 0.01). Increased awareness of patients about the rules for preparing for endoscopic examination and a reminder of the date and time of the upcoming endoscopy, there was an increase in the number of patients who completed stage 2 of health examination to exclude/confirm oncopathology (from 79.6 to 90 %; p < 0.05). The frequency of violations by doctors of the oncological screening algorithm decreased from 13.8 to 2.3 % (p < 0.01).Conclusion. The use of lean manufacturing marketing strategies in primary health care has helped to identify, eliminate and control the causes of problems during the first and second stages of clinical examination of patients with suspected oncopathology

Improving Methodological Approach to Measures Planning for Hydraulic Fracturing in Oil Fields

Goal of the research is development of an integrated approach to the planning of hydraulic fracturing (HF) treatment taking into account geo-technical, hydrodynamic, technological and economic criteria for the selection of wells for inclusion in the programs of HF with increasing importance of economic criteria. Stages of formation of the program for HF of the oil company are selected, systematized and analyzed. It is shown that high potential effectiveness of enhanced oil recovery method in fields with hard-to-recover reserves, on the one hand, and the complexity and high cost of application, on the other, determine the need to optimize the parameters of this business process at all stages of implementation and improve its planning methods. The priority directions for improving the hydraulic fracturing planning were justified: a clear definition of the criterion for the payback period of hydraulic fracturing activities, taking into account their technological features, improving the procedure for calculating the costs of implementing this technology and improving the reasonableness of selecting candidate wells for inclusion in the hydraulic fracturing program. Feasibility of using an additional criterion in the formation of hydraulic fracturing programs – marginal minimum cost-effective wall capacity – has been shown and a method for calculating it has been developed. The use of this criterion will allow to take into account not only technological limitations, but also limits of economic efficiency of conducting hydraulic fracturing at each specific well and, at the preliminary selection of candidate wells, exclude a priori unprofitable measures. It is advisable to take into account proposed directions for improving planning of hydraulic fracturing in the development of corporate regulatory documents, which will help to improve the quality of planning geological and technical measures, minimize investment risks, make more rational use of oil companies' resources for improving oil recovery, choosing the best management decision

Fe/Co Alloys for the Catalytic Chemical Vapor Deposition Synthesis of Single- and Double-Walled Carbon Nanotubes (CNTs). 1. The CNT−Fe/Co−MgO System

Mg0.90FexCoyO (x + y ) 0.1) solid solutions were synthesized by the ureic combustion route. Upon reduction at 1000 °C in H2-CH4 of these powders, Fe/Co alloy nanoparticles are formed, which are involved in the formation of carbon nanotubes, which are mostly single and double walled, with an average diameter close to 2.5 nm. Characterizations of the materials are performed using 57Fe Mo¨ssbauer spectroscopy and electron microscopy, and a well-established macroscopic method, based on specific-surface-area measurements, was applied to quantify the carbon quality and the nanotubes quantity. A detailed investigation of the Fe/Co alloys’ formation and composition is reported. An increasing fraction of Co2+ ions hinders the dissolution of iron in the MgO lattice and favors the formation of MgFe2O4-like particles in the oxide powders. Upon reduction, these particles form R-Fe/Co particles with a size and composition (close to Fe0.50Co0.50) adequate for the increased production of carbon nanotubes. However, larger particles are also produced resulting in the formation of undesirable carbon species. The highest CNT quantity and carbon quality are eventually obtained upon reduction of the iron-free Mg0.90Co0.10O solid solution, in the absence of clusters of metal ions in the starting material. Introduction Catalyti

Zero modes, beta functions and IR/UV interplay in higher-loop QED

We analyze the relation between the short-distance behavior of quantum field theory and the strong-field limit of the background field formalism, for QED effective Lagrangians in self-dual backgrounds, at both one and two loop. The self-duality of the background leads to zero modes in the case of spinor QED, and these zero modes must be taken into account before comparing the perturbative beta function coefficients and the coefficients of the strong-field limit of the effective Lagrangian. At one-loop this is familiar from instanton physics, but we find that at two-loop the role of the zero modes, and the interplay between IR and UV effects in the renormalization, is quite different. Our analysis is motivated in part by the remarkable simplicity of the two-loop QED effective Lagrangians for a self-dual constant background, and we also present here a new independent derivation of these two-loop results.Comment: 15 pages, revtex