The Insider - video art

Video art, with text by Booker Prize Winner Ben Ben Okri. Commissioned by ‘The Coronet theatre’ (a fringes theatre) to accompany Albert Camus’ ‘The Outsider’, adapted for stage By Ben Okri

'Looking back' - on the young unemployed

This is a photographic work made in 2013/2014 when under David Cameron’s government “the youth unemployment reached the highest level…the UK has seen in modern times"

‘You don’t know what nights are like?’ – public art project

A major billboard project commissioned by the ‘Art on the Underground’ (initially as a response to the launch of the night trains), entitled ‘You don’t know what nights are like?’. It focuses on ‘night - time workers’, with a number of interviews made with those who work between 8 to 12 hour night shifts , including Laura, the figure in the first image here, who has been working as a security guard,12 hour night shift for the last 16 years (pls see interviews

Gholam- British/Iranian feature film

Set in London, Gholam is the story of an enigmatic Iranian cab driver, who works at night and doesn’t like to talk about his past. He has two jobs, yet seems not to be interested in the money. He eats at his uncle’s café every day, yet is fully aware of being betrayed by him. He agrees to the arrangement his mother makes for his return home, yet has no intention of going back. And we learn that he was once a war hero, and yet disappeared from the battlefield without a trace. A man with no past, no future, no 'conviction', he still gets involved in the conflict of a total stranger and carries it through to the very end

Is liquid biopsy the future commutator of decision-making in liver transplantation for hepatocellular carcinoma?

Liver transplant (LT) is the most favorable treatment option for patients with early stage hepatocellular carcinoma (HCC). Numerous attempts have been pursued to establish eligibility criteria and select HCC patients for LT, leading to various systems that essentially integrate clinico-morphological variables. Lacking of sufficient granularity to recapitulate the biological complexity of the disease, all these alternatives display substantial limitations and are thus undeniably imperfect. Liquid biopsy, defined as the molecular analysis of circulating analytes released by a cancer into the bloodstream, was revealed as an incomparable tool in the management of cancers, including HCC. It appears as an ideal candidate to refine selection criteria of LT in HCC. The present comprehensive review analyzed the available literature on this topic. Data in the field, however, remain scarce with only 17 studies. Although rare, these studies provided important and encouraging findings highlighting notable prognostic values and supporting the contribution of liquid biopsy in this specific clinical scenario. These results underpinned the critical and urgent need to intensify and accelerate research on liquid biopsy, in order to determine whether and how liquid biopsy may be integrated in the decision-making of LT in HCC

An experimental study of the effects of swept angle on the boundary layer of the 2D wing

Paper presented at the 9th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Malta, 16-18 July, 2012.dc201

Feasibility and safety of liver transplantation or resection after transarterial radioembolization with Yttrium-90 for unresectable hepatocellular carcinoma.

The benefit of transarterial radioembolization (TARE) in patients with unresectable hepatocellular carcinoma (HCC) is increasingly evidenced. However, data on outcome of liver transplantation or resection after TARE remain scarce. This study aimed to assess the safety and feasibility of surgery after TARE in patients with unresectable HCC. Patients exclusively undergoing TARE followed by either orthotopic liver transplantation (OLT) or liver resection (LR) for HCC between 2012 and 2016 were included. Primary outcomes were postoperative morbidity and mortality. Secondary outcomes were overall survival (OS) and response to TARE. Among 349 patients with HCC treated with TARE, 32 (9%) underwent either OLT (n = 22) or LR (n = 10), which represent the study cohort. In this group, TARE induced decreased viable nodules (p < 0.001), an efficient downsizing (p < 0.001) as well as a significant downstaging based on BCLC classification (p < 0.001). Overall, major complications and mortality after surgery occurred in 5 (16%) and 1 (3%) patients, respectively. For the whole study cohort, OS was 47 months while survival rates at 1-, 3- and 5-years reached 97%, 86% and 86%, respectively. Liver surgery after TARE is feasible and safe. This strategy allows to offer a curative treatment in a subset of patients with unresectable HCC

Effects of training in the Morris water maze on the spatial learning acquisition and VAChT expression in male rats

"n  "n  Background and the purpose of the study: It has been well established that cholinergic pathway plays an important role in learning and memory processes. The present study was designed to evaluate the effects of Morris water maze (MWM) training on spatial memory acquisition and expression of the vesicular acetylcholine transporter (VAChT) in male rats. "n  Methods: In this study, training trials of all groups of animals were conducted in the MWM task. Rats received one training session consisting of four trials per day which continued for another four consecutive days. Controls received visible platform MWM training. The escape latency, the traveled distance and swimming speed for each rat were recorded and used to evaluate the performance of the animal during training period. For evaluation of expression of VAChT protein levels, brain tissues from animals in each experiment were obtained immediately after the last trial on the related experimental day and processed for immunohistochemistry staining and western blotting analysis. "n  Results: There was a significant difference between animals subjected to one day training and those receiving four days of training in escape latency and travel distance. There were an apparent increase in VAChT immunoreactivity in the medial septal area (MSA) and CA1 region of the hippocampus in one day and four day trained animals compared with controls (visible group). Quantitative immunostaining analysis by optical density measurements in the CA1 region and evaluation of immunopositive neurons in medial septal area of brain sections confirmed qualitative findings. Assessment of VAChT protein level expression in hippocampus by western blotting evaluation showed the same pattern of immunohistochemistry results. "n  Conclusion: Overall, results of this study reveal changes in cholinergic neuron activity in different stages of training in the MWM task. Data suggest that there is a significant level of cholinergic neuronal activity during early stages of the training especially in the hippocampus region that may contribute to the apparent increase in VAChT expression

An experimental study on boundary layer transition detection over a pitching supercritical airfoil using hot-film sensors

In the present work, experimental tests are conducted to study boundary layer transition over a supercritical airfoil undergoing pitch oscillations using hot-film sensors. Tests have been undertaken at an incompressible flow. Three reduced frequencies of oscillations and two mean angles of attack are studied and the influences of those parameters on transition location are discussed. Different algorithms are examined on the hot-film signals to detect the transition point. Results show the formation of a laminar separation bubble near the leading edge and at relatively higher angles of attack which leads to the transition of the boundary layer. However, at lower angles of attack, the amplification of the peaks in voltage signal indicate the emergence of the vortical structures within the boundary layer, introducing a different transition mechanism. Moreover, an increase in reduced frequency leads to a delay in transition onset, postponing it to a higher angle of attack, which widens the hysteresis between the upstroke and downstroke motions. Rising the reduced frequency yields in weakening or omission of vortical disturbances ensuing the removal of spikes in the signals. Of the other important results observed, is faster movement of the relaminarization point in the higher mean angle of attack. Finally, a time–frequency analysis of the hot-film signals is performed to investigate evolution of spectral features of the transition due to the pitching motion. An asymmetry is clearly observed in frequency pattern of the signals far from the bubble zone towards the trailing edge; this may reflect the difference between the transition and relaminarization physics. Also, various ranges of frequency were obtained for different transition mechanisms

A review of the pharmacological and therapeutic effects of auraptene

There is a growing awareness in herbal medications as they are usually safe and devoid of significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether and is consumed all over the world. There is growing evidence of the therapeutic benefits of auraptene. Auraptene, also known as auraptene and 7‐geranyloxycoumarin, is a bioactive monoterpene coumarin from Rutaceae family, which is isolated from Citrus aurantium (Seville orange) and Aegle marmelos (bael fruit). Auraptene is a highly pleiotropic molecule, which can modulate intracellular signaling pathways that control inflammation, cell growth, and apoptosis. It has a potential therapeutic role in the prevention and treatment of various diseases due to its anti‐inflammatory and antioxidant activities as well as its excellent safety profile. In the present article, various pharmacological and therapeutic effects of auraptene were reviewed. Different online databases using keywords such as auraptene, therapeutic effects and pharmacological effects were searched until the end of September 2018, for this purpose. Auraptene has been suggested to be effective in the treatment of a broad range of disorders including inflammatory disorders, dysentery, wounds, scars, keloids, and pain. In addition, different studies have demonstrated that auraptene possesses numerous pharmacological properties including anti‐inflammatory, anti‐oxidative, anti‐diabetic, anti‐hypertensive and anti‐cancer as well as neuroprotective effects. The present review provides a detailed survey of scientific researches regarding pharmacological properties and therapeutic effects of auraptene