Edifici universitari ai Mercati Generali a Roma

All’interno di un settore urbano di grande importanza strategica, vengono analizzati i possibili modi di riuso dei Mercati Generali, complesso umbertino costruito agli inizi del ‘900 per dotare la nuova capitale del Regno delle necessarie attrezzature. Il progetto suddivide il complesso in due comparti. Quello occupato dai padiglioni storici è destinato a spazi commerciali, servizi al pubblico e uffici circoscrizionali, mentre l’altro ospita i nuovi insediamenti dell’Università di RomaTre

EPR and Fluorescence Spectroscopy in the Photodegradation Study of Arabian and Colombian Crude Oils

EPR and fluorescence spectroscopy were used to evaluate the degradation of crude oils of different origins that were submitted to photochemical weathering under tropical conditions. The EPR spectra obtained showed signals of the paramagnetic species: the vanadyl VO2+ ion and organic free radicals. A decrease in linewidth of free radical signals was observed for both oils irradiated for 100 hours with sunlight of 350 W/m2. The reduction in the linewidth of the free radical of 9.8% in Arabian oil and 18.5% in Colombian oil, as well as the decrease in radical numbers, indicated photochemical degradation, especially in Colombian oil. The linewidth narrowing corresponding to free radicals in the irradiated oils occurred due to the rearrangement among radicals and aromatic carbon consumption. The irradiated oils showed a reduction in the relative intensity of fluorescence of the aromatics with high molecular mass, polar aromatics, and asphaltene. The fluorescent fraction was reduced by 61% in Arabian oil and 72% in Colombian oil, corresponding to photochemical degradation of crude oil aromatic compounds

Optimal predictive sample size for case-control studies

The identification of factors that increase the chances of a certain disease is one of the classical and central issues in epidemiology. In this context, a typical measure of the association between a disease and risk factor is the odds ratio. We deal with design problems that arise for Bayesian inference on the odds ratio in the analysis of case-control studies. We consider sample size determination and allocation criteria for both interval estimation and hypothesis testing. These criteria are then employed to determine the sample size and proportions of units to be assigned to cases and controls for planning a study on the association between the incidence of a non-Hodgkin's lymphoma and exposition to pesticides by eliciting prior information from a previous study. Copyright 2004 Royal Statistical Society.

Endovascular repair of an aorto-iliac aneurysm succeeded by kidney transplantation Tratamento endovascular de aneurisma aorto-ilíaco sucedido por transplante renal

We present the case of aorto-iliac aneurysm in a patient with chronic renal failure requiring dialysis who were treated with an endovascular stent graft and, later on, submitted to kidney transplantation. A 53-year-old male with renal failure requiring dialysis presented with an asymptomatic abdominal aorto-iliac aneurysm measuring 5.0cm of diameter. He was treated with endovascular repair technique, being used an endoprosthesis Excluder®. After four months, he was successfully submitted to kidney transplantation (dead donor), with anastomosis of the graft renal artery in the external iliac artery distal to the endoprosthesis. The magnetic resonance imaging, carried out 30 days after the procedure, showed a good positioning of the endoprosthesis and adequate perfusion of the renal graft. In the follow-up, the patient presented improvement of nitrogenous waste, good positioning of the endoprosthesis without migration or endoleak. The endovascular repair of aorto-iliac aneurysm in a patient with end-stage renal failure under hemodialysis treatment showed to be feasible, safe and efficient, as it did not prevent the success of the posterior kidney transplantation.<br>Apresentamos o caso de aneurisma aortoilíaco em um paciente com insuficiência renal crônica dialítica tratado com uma endoprótese vascular, sendo, após, submetido a transplante renal. Um homem de 53 anos com insuficiência renal dialítica apresentava um aneurisma abdominal aortoilíaco assintomático com 5,0cm de diâmetro. Foi tratado com técnica endovascular com uma endoprótese Excluderâ. Após quatro meses, foi submetido a transplante renal (doador cadáver) com sucesso, com anastomose da artéria renal do enxerto na artéria ilíaca externa distal à endoprótese. A ressonância magnética 30 dias após o procedimento mostrou a endoprótese bem posicionada e o enxerto renal bem perfundido. No seguimento, o paciente evoluiu com melhora das escórias nitrogenadas, bom posicionamento da endoprótese, sem migração ou endoleak. O reparo endovascular do aneurisma aortoilíaco em paciente com insuficiência renal terminal em hemodiálise mostrou-se exequível, seguro e eficaz, e não comprometeu o sucesso do transplante renal posterior

Estudo da isquemia e reperfusão em retalhos cutâneos de ratos The study of the ischemia and reperfusion in skin flaps of rats

INTRODUÇÃO: Múltiplos fatores têm sido implicados na patogênese da lesão de isquemia/reperfusão da pele, incluindo as espécies reativas de oxigênio. OBJETIVO: Estudar a lesão de isquemia/reperfusão em retalhos cutâneos de ratos avaliando os níveis teciduais do malonildialdeído (MDA) e xantina oxidase (XO). MÉTODOS: Foram utilizados 8 ratos Wistar, com peso entre 300 - 400g, sendo confeccionados 2 retalhos epigástricos por animal (controle e experimento), um deles submetido à 16h de isquemia (RI) seguida de 45 min de reperfusão (RR) e o outro controle (RC). Foram colhidas 3 biópsias de pele dos retalhos (RC, RI, RR) e encaminhadas para dosagem de MDA e XO. RESULTADOS: A análise bioquímica mostrou aumento significativo dos níveis teciduais de MDA e XO após a reperfusão em relação aos retalhos controles. CONCLUSÃO: Retalhos epigástricos de ratos submetidos à 16h de isquemia e 45min de reperfusão apresentam elevação dos níveis teciduais de MDA e XO, caracterizando a lipoperoxidação da membrana celular.<br>INTRODUCTION: Multiple factors have been implicated in the pathogenesis of reperfusion injury in the skin, including the reactive oxygen species. OBJECTIVE: The aim was to evaluate the effect of reperfusion injury in the rat skin flap evaluated by tissue assay for malonyldialdehyde (MDA) and xanthine oxidase (XO). METHODS: 8 Wistar rats were used, between 300-400g weight and two identical epigastric flaps were raised in each animal (control and experiment), the vasculature of one flap was left intact and in the second flap the arterial pedicle was clamped for 16 hours and reperfused for 45 minutes. Skin samples were obtained from each flap after these periods of time and submitted to MDA and XO analysis. RESULTS: Reperfused flaps had significantly increased MDA and XO values compared to the control flaps biopsies. CONCLUSION: The lipid peroxidation levels were higher in the rat epigastric skin flaps subjected to 16 hours of ischemia and 45 minutes of reperfusion