Bacterial pathogens causing neonatal sepsis in an out-born neonatal unit in Lagos, Nigeria

No Abstract. NQJHM Vol. 6 (3) 1996: pp. 149-15

A study on pediatric nosocomial methicillin - resistant Staphlococcus aureus in Lagos, Nigeria

This work was undertaken to determine the incidence of nosocomial methicillin–resistant Staphylococcus aureus (MRSA) infections in children at a tertiary hospital and the antibiotic susceptibility profiles of MRSA compared with methicillin–sensitive (MSSA) strains. From 1994 to 1995, 4,981 admissions in the neonatal intensive care, paediatric surgical, general paediatric, and the well–baby wards of the Lagos University Teaching Hospital were prospectively monitored for nosocomial S. aureus infections. Antibiotic testing was performed on a total of 175 isolates of S. aureus obtained from 169 patients with nosocomial infections (NI) using a disk diffusion method and by E test (AB Biodisk, Sweden). In total, nosocomial MRSA infection was identified in 96 (1.9%) patients, rates recorded for patients in the various wards as stated above were 4.2%, 3.2%, 0.5% and 0% respectively. Correspondingly, the rate of nosocomial MRSA amongst all S. aureus infections was 63.6%, 44.7%, 41.7% and 0%, and 54.9% overall. All MRSA and MSSA were sensitive to ciprofloxacin and vancomycin. Clindamycin and rifampin (87-98%) were also highly effective against MRSA and MSSA, 78.3 % of MRSA and 91.7% MSSA were sensitive to fusidic acid. Gentamicin (70.9%) and erythromycin (65.8%) were also active on MSSA. Cotrimoxazole had low activity against all the strains. Following the high rate and multiresistant nature of nosocomial MRSA obtained in this study, there is need for intensive surveillance of such infections and initiation of stringent control measures in Nigeria and Africa at large.International Journal of Biological & Chemical Sciences Vol. 1 (1) 2007: pp. 54-6

Bacterial pathogens and their antimicrobial susceptibitily patterns in the Out-Patient setting in Lagos

No Abstract. NQJHM Vol. 8 (4) 1998: pp. 256-26

Neonatal Mortality of Inborns in the Neonatal Unit of a Tertiary Centre in Lagos, Nigeria.

Background: Neonatal mortality is a useful index of assessing the socioeconomic development of an area. Its periodic evaluation is therefore a necessary and valuable audit index of the care given. The aim of this study is to document the neonatal mortality rate of inborn babies at Lagos University Teaching Hospital (LUTH) and describe the pattern of these deaths. Study Design: In-born neonatal admissions at the LUTH over a five-year period (January 1996 – December 2000) were retrospectively reviewed. Data on mortality, pregnancy, delivery and neonatal indices were extracted from ward records. Results: There were a total of 6,272 live births of whom 2,496 (39.8%) were admitted into the neonatal unit. One hundred and forty one of the neonates died giving a mortality rate of 22.5/1000. The neonatal deaths comprised of 120 early neonatal deaths and 39 late neonatal deaths. The yearly neonatal mortality rate showed a steady decline except for 1999 during which there was a slight rise. The incidence of neonatal deaths decreased with age, weight at birth and maturity. Low birth weight and birth asphyxia were the leading associated causes of death. Complications of pregnancy occurred in 45.4% of the mothers of these neonates with pregnancy induced hypertension as the most prevalent (62.5%). Conclusion: An overall inborn neonatal mortality rate of 22.5/1000 in our institution is still high but a declining trend is portrayed and will be further improved with the institution of measures to control or reduce the incidence of pregnancy induced hypertension, low birth weight and birth asphyxia. Keywords: Neonatal mortality, inborn babies, low birth-weight, hypertension, birth asphyxia, Lagos, Nigeria.NQJHM Vol. 15 (2) 2005: pp. 55-5

Prune Belly Syndrome: A case Report

The Prune Belly Syndrome (PBS) is a anomaly. It comprises of a lax abdominal wall musculature, urinary tract anomalies, and cryptorchidism. Our patients had urinary tract infection and renal failure. These are well described consequences of the syndrome and are poor prognostic indices. This case report was undertaken in order to highlight the occurrence of this rare syndrome in our environment and to review its pathogenesis, presentation and management approach. The case for prenatal diagnosis and early integrated treatment is further discussed. Keywords: Prune belly syndrome, presentation, management. NQJHM Vol. 14 (2) 2004: pp. 175-17

Congenical malformations in Lagos: a survey of 22,288 consecutive newborns in the Lagos University Teaching Hospital (LUTH) over a 10-year period

No Abstract. NQJHM Vol. 8 (4) 1998: pp. 272-27