29 research outputs found
Superposition rules for higher-order systems and their applications
Superposition rules form a class of functions that describe general solutions
of systems of first-order ordinary differential equations in terms of generic
families of particular solutions and certain constants. In this work we extend
this notion and other related ones to systems of higher-order differential
equations and analyse their properties. Several results concerning the
existence of various types of superposition rules for higher-order systems are
proved and illustrated with examples extracted from the physics and mathematics
literature. In particular, two new superposition rules for second- and
third-order Kummer--Schwarz equations are derived.Comment: (v2) 33 pages, some typos corrected, added some references and minor
commentarie
ΠΡΠΎΠ½Ρ ΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΡ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π»Π΅Π³ΠΊΠΈΡ
Bronchial complications are among the main causes of impairing postoperative period and thansplant failure. Severe bronchial complications are very rare but have a high mortality rate. Light forms decrease transplant function and while progressing can leads to life-threatening conditions without required treatment. Nowadays there is a huge necessity in classification of diagnostic and bronchial complications treatment on different terms after lung transplantation. Methods of observation bronchoscopy and interventional bronchology are allowing us to realize prevention, diagnostic and treatment bronchial complications.ΠΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΡ ΡΠ²Π»ΡΡΡΡΡ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΏΡΠΈΡΠΈΠ½ ΡΡΠΆΠ΅Π»ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠΈΠΎΠ΄Π° ΠΈ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΡΡ
ΠΈΡΡ
ΠΎΠ΄ΠΎΠ² Ρ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² Π΄ΠΎΠ½ΠΎΡΡΠΊΠΈΡ
Π»Π΅Π³ΠΊΠΈΡ
. ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π½ΠΈΠ·ΠΊΡΡ ΡΠ°ΡΡΠΎΡΡ ΡΡΠΆΠ΅Π»ΡΡ
ΡΠΎΡΠΌ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ, ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡ Π²ΡΡΠΎΠΊΡΡ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΡΡΡ, Π² ΡΠΎ Π²ΡΠ΅ΠΌΡ ΠΊΠ°ΠΊ Π»Π΅Π³ΠΊΠΈΠ΅ ΡΠΎΡΠΌΡ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Π±Π΅Π· Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΡ
ΡΠ΄ΡΠ°ΡΡ ΡΡΠ½ΠΊΡΠΈΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠ° ΠΈ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΆΠΈΠ·Π½ΠΈ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠ°, ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΡΡ, ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡ ΠΊ ΠΆΠΈΠ·Π½Π΅ΡΠ³ΡΠΎΠΆΠ°ΡΡΠΈΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΡΠΌ. ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° ΠΎΠ±ΠΈΠ»ΠΈΠ΅ Π½Π°ΡΡΠ½ΡΡ
ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ, ΡΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΡ Π² ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Π½Π° ΡΠ°Π·Π½ΡΡ
ΡΡΠΎΠΊΠ°Ρ
ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ, ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΠΎΠ»ΠΈ ΠΎΠ±ΡΠ΅ΡΠ²Π°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π±ΡΠΎΠ½Ρ
ΠΎΡΠΊΠΎΠΏΠΈΠΈ ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΠ½ΡΠ΅ΡΠ²Π΅Π½ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π±ΡΠΎΠ½Ρ
ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π² ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠ΅, Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ
Π‘ΠΠΠ ΠΠΠΠΠΠ«Π ΠΠ‘ΠΠΠΠ’Π« ΠΠΠ§ΠΠΠΠ― Π‘Π’ΠΠΠΠΠΠ ΠΠΠ Π’ΠΠΠ Π Π’Π ΠΠ₯ΠΠ ΠΠΠ‘ΠΠ Π€Π£ΠΠΠ¦ΠΠΠΠΠΠ¬ΠΠ-Π©ΠΠΠ―Π©ΠΠ₯ ΠΠΠΠ ΠΠ¦ΠΠ
Treatment and rehabilitation of patients with cancer of the larynx is a complex issue, as the majority of patients (60-70%) are diagnosed at the III and IV stages of the disease. The main type of surgery is a laryngectomy which leads to organ dysfunction and disability. It is known that in cases of locally advanced laryngeal tumors resection may be performed. However, after these operations from 22 to 57% of patients couldnβt be rehabilitated due to the difficulty in creating of sufficient lumen of the larynx, development of chondroperihondritis, growth of granulation tissue, fibrosis formation and stenosis of the larynx (Bukhman L.A., 1982; Bityutskij P.T., 1990; Park H.Y., 2009; SoYeonLimatal, 2012).ΠΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΈ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ°ΠΊΠΎΠΌ Π³ΠΎΡΡΠ°Π½ΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ»ΠΎΠΆΠ½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΠΉ, ΡΠ°ΠΊ ΠΊΠ°ΠΊ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ Π±ΠΎΠ»ΡΠ½ΡΡ
(60β70%) ΠΏΠΎΡΡΡΠΏΠ°ΡΡ Π½Π° Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π² 3 ΠΈ 4 ΡΡΠ°Π΄ΠΈΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΡΠ½ΠΎΠ²Π½ΡΠΌ Π²ΠΈΠ΄ΠΎΠΌ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° ΡΠ²Π»ΡΠ΅ΡΡΡ Π»Π°ΡΠΈΠ½Π³ΡΠΊΡΠΎΠΌΠΈΡ ΠΊΠΎΡΠΎΡΠ°Ρ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΉ ΠΎΡΠ³Π°Π½Π° ΠΈ ΠΈΠ½Π²Π°Π»ΠΈΠ΄ΠΈΠ·Π°ΡΠΈΠΈ. ΠΠ·Π²Π΅ΡΡΠ½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ ΠΌΠ΅ΡΡΠ½ΠΎ β ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ
Π³ΠΎΡΡΠ°Π½ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ ΡΠ΅Π·Π΅ΠΊΡΠΈΠΉ. ΠΠ΄Π½Π°ΠΊΠΎ ΠΏΠΎΡΠ»Π΅ ΡΡΠΈΡ
ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΉ Π½ ΡΠ΄Π°Π΅ΡΡΡ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠΈΡΠΎΠ²Π°ΡΡ ΠΎΡ 22 Π΄ΠΎ 57% Π±ΠΎΠ»ΡΠ½ΡΡ
Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΡΡΡΠ΄Π½ΠΎΡΡΠ΅ΠΉ ΠΏΡΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΠΈ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ²Π΅ΡΠ° Π³ΠΎΡΡΠ°Π½ΠΈ, ΡΠ°Π·Π²ΠΈΡΠΈΡ Ρ
ΠΎΠ½Π΄ΡΠΎΠΏΠ΅ΡΠΈΡ
ΠΎΠ½Π΄ΡΠΈΡΠ°, ΡΠΎΡΡΠ° Π³ΡΠ°Π½ΡΠ»ΡΡΠΈΠΉ, ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ±ΡΠΎΠ² ΠΈ ΡΡΠ΅Π½ΠΎΠ·Π° ΡΡΠΎΠ³ΠΎ ΠΎΡΠ³Π°Π½Π°. (Π. Π. ΠΡΡ
ΠΌΠ°Π½ 1982Π³, Π. Π’. ΠΠΈΡΡΡΠΊΠΈΠΉ 1990, Park H. Y., 2009; SoYeonLimatal., 2012 ΠΈ Π΄Ρ. ΡΠΎΠ°Π²ΡΠΎΡΡ)
ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΌΠΈΠΊΡΠΎΠ ΠΠ Ρ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ : ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠΌΠΈ Π΄Π°Π½Π½ΡΠΌΠΈ
Objective: to evaluate the expression levels of miRNA (miR-27, miR-101, miR-142, miR-339 and miR-424) and its relationship with clinical and laboratory parameters in lung transplant recipients. Materials and methods. The study included 57 lung recipients aged 10 to 74 years (35 Β± 15), including six children (9%) β four boys 10, 12, 13 and 17 years and girls 13 and 14 years old β and 51 adult recipients, including 30 men (62.5%). The control group was made up of 14 healthy individuals that were not significantly different by gender and age. Expression levels of the microRNAs studied in blood plasma were determined via quantitative polymerase chain reaction (PCR). Correlations of miRNA expression levels with complete blood count and biochemical blood test indicators were analyzed. Results. Patients with end-stage chronic respiratory failure (potential lung recipients) were found to have significantly higher expression levels of miR-27, miR-101 and miR-339 in plasma than the healthy individuals (p = 0.02, p = 0.03 and p = 0.01, respectively). The expression level of miR-339 correlated with the age of potential lung recipients (p = 0.04). It was a negative correlation (r = β0.46). The expression levels of the other four miRNAs were age independent. The average expression level of miR-424 in lung recipients in the long-term period after lung transplant was higher than in waitlisted patients (p = 0.03). Analysis of the relationship between miRNA expression levels and external respiration function in the long-term post-transplant period showed that miR-142 expression level (r = 0.61; p = 0.04) positively correlates with the Tiffeneau-Pinelli index. This strong correlation, which exceeds 85%, indicates the presence of restrictive lung diseases. A year and more after transplantation, it was found that in the recipients, there were close positive correlations between miR-27, miR-142, miR-424 expression levels and blood leukocyte concentration, as well as between the miR-142 expression level and the sCD40L concentration during this period. Conclusion. A comparative study of the expression level of miRNAs (miR-27, miR-101, miR-142, miR-339 and miR-424) in the blood plasma of patients suffering from end-stage chronic lung diseases of various origin and in lung recipients enables us to conclude that further studies of the miRNA panels are needed in order to assess their effectiveness as potential molecular and genetic markers of post-transplant complications.Π¦Π΅Π»Ρ: ΠΎΡΠ΅Π½ΠΈΡΡ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΌΠΈΠΊΡΠΎΠ ΠΠ (miR-27, miR-101, miR-142, miR-339 ΠΈ miR-424) ΠΈ Π΅Π΅ ΡΠ²ΡΠ·Ρ Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠΌΠΈ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠ°ΠΌΠΈ Ρ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π»Π΅Π³ΠΊΠΈΡ
. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 57 ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ
Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 10 Π΄ΠΎ 74 Π»Π΅Ρ (Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ 35 Β± 15), ΡΡΠ΅Π΄ΠΈ ΠΊΠΎΡΠΎΡΡΡ
ΡΠ΅ΡΡΠ΅ΡΠΎ Π΄Π΅ΡΠ΅ΠΉ (9%) β ΡΠ΅ΡΡΡΠ΅ ΠΌΠ°Π»ΡΡΠΈΠΊΠ° 10, 12, 13 ΠΈ 17 Π»Π΅Ρ ΠΈ Π΄Π΅Π²ΠΎΡΠΊΠΈ 13 ΠΈ 14 Π»Π΅Ρ β ΠΈ 51 Π²Π·ΡΠΎΡΠ»ΡΠΉ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½Ρ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ 30 ΠΌΡΠΆΡΠΈΠ½ (62,5%). ΠΡΡΠΏΠΏΡ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 14 Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π»ΠΈΡ, Π·Π½Π°ΡΠΈΠΌΠΎ Π½Π΅ ΠΎΡΠ»ΠΈΡΠ°ΡΡΠΈΡ
ΡΡ ΠΏΠΎ ΠΏΠΎΠ»Ρ ΠΈ Π²ΠΎΠ·ΡΠ°ΡΡΡ. Π£ΡΠΎΠ²Π½ΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΌΠΈΠΊΡΠΎΠ ΠΠ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΠ΅ΠΏΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ (ΠΠ¦Π ). ΠΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΡΡ Π°Π½Π°Π»ΠΈΠ· ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ²ΡΠ·Π΅ΠΉ ΡΡΠΎΠ²Π½Π΅ΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΌΠΈΠΊΡΠΎΠ ΠΠ Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΠΎΠ±ΡΠ΅Π³ΠΎ ΠΈ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·ΠΎΠ² ΠΊΡΠΎΠ²ΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ miR-27, miR-101 ΠΈ miR-339 Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡΠΎΠ²ΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΡΠ°Π΄ΠΈΠ΅ΠΉ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ (ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ
) ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎ Π·Π΄ΠΎΡΠΎΠ²ΡΠΌΠΈ Π»ΠΈΡΠ°ΠΌΠΈ (Ρ = 0,02, Ρ = 0,03 ΠΈ Ρ = 0,01 ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ). ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΡΠ΅ΡΡΡΠ΅Ρ
ΠΈΠ· ΠΏΡΡΠΈ Π½Π΅ Π·Π°Π²ΠΈΡΠ΅Π»Π° ΠΎΡ Π²ΠΎΠ·ΡΠ°ΡΡΠ°. Π£ΡΠΎΠ²Π΅Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ miR-339 ΠΊΠΎΡΡΠ΅Π»ΠΈΡΠΎΠ²Π°Π» Ρ Π²ΠΎΠ·ΡΠ°ΡΡΠΎΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ
(p = 0,04), ΠΈ ΡΠ²ΡΠ·Ρ Π½ΠΎΡΠΈΠ»Π° ΠΎΠ±ΡΠ°ΡΠ½ΡΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ, r = β0,46. Π‘ΡΠ΅Π΄Π½ΡΡ Π²Π΅Π»ΠΈΡΠΈΠ½Π° ΡΡΠΎΠ²Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ miR-424 Ρ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ
Π² ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ ΠΏΠΎΡΠ»Π΅ Π’Π ΠΎΠΊΠ°Π·Π°Π»Π°ΡΡ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΎΠΆΠΈΠ΄Π°ΡΡΠΈΡ
ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ (Ρ = 0,03). ΠΡΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΡΠ²ΡΠ·ΠΈ ΡΡΠΎΠ²Π½Π΅ΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΌΠΈΠΊΡΠΎΠ ΠΠ Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΡΡΠ½ΠΊΡΠΈΠΈ Π²Π½Π΅ΡΠ½Π΅Π³ΠΎ Π΄ΡΡ
Π°Π½ΠΈΡ Π² ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΠΎΠΌ ΠΏΠΎΡΡΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½Π°Ρ ΠΏΡΡΠΌΠ°Ρ ΡΠ²ΡΠ·Ρ ΡΡΠΎΠ²Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ miR-142 (r = 0,61; p = 0,04) Ρ ΠΈΠ½Π΄Π΅ΠΊΡΠΎΠΌ Π’ΠΈΡΡΠ½ΠΎ, Π²Π΅Π»ΠΈΡΠΈΠ½Π° ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ Π±ΠΎΠ»Π΅Π΅ 85% ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎ ΡΠ΅ΡΡΡΠΈΠΊΡΠΈΠ²Π½ΡΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΡΡ
Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΡΠ΅ΠΉ. Π§Π΅ΡΠ΅Π· Π³ΠΎΠ΄ ΠΈ Π±ΠΎΠ»Π΅Π΅ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Ρ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² Π²ΡΡΠ²Π»Π΅Π½Ρ ΡΠ΅ΡΠ½ΡΠ΅ ΠΏΡΡΠΌΡΠ΅ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΡΡΠΎΠ²Π½Π΅ΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ miR-27, miR-142 ΠΈ miR-424 Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠ΅ΠΉ Π»Π΅ΠΉΠΊΠΎΡΠΈΡΠΎΠ² Π² ΠΊΡΠΎΠ²ΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΡΠΎΠ²Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ miR-142 Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠ΅ΠΉ sCD40L Π² ΡΡΠΎΡ ΠΏΠ΅ΡΠΈΠΎΠ΄. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π‘ΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΌΠΈΠΊΡΠΎΠ ΠΠ (miR-27, miR-101, miR-142, miR-339 ΠΈ miR-424) Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΡΡΡΠ°Π΄Π°ΡΡΠΈΡ
Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Π»Π΅Π³ΠΊΠΈΡ
ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ Π² ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΡΠ°Π΄ΠΈΠΈ, ΠΈ Ρ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ
ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠ΄Π΅Π»Π°ΡΡ Π·Π°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΎ ΡΠ΅Π»Π΅ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎΡΡΠΈ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠ°Π½Π΅Π»ΠΈ ΠΌΠΈΠΊΡΠΎΠ ΠΠ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΈΡ
ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΠΏΠΎΡΡΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ
ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΡΠΈΠΎΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π² ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π»Π΅Π³ΠΊΠΈΡ ΠΈ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-Π»Π΅Π³ΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°
Bronchial complications, along with development and progression of chronic dysfunction on the background of chronic rejection, are factors that reduce the quality and life of lung and heart-lung recipients. They also increase the frequency of hospitalizations. Application of cryotechnology is based on the contact effect of extremely low temperatures on organs and tissues using a cryoprobe. This article demonstrates the experience of using cryotechnology in the diagnosis and treatment of complications in lung and heart-lung recipients.ΠΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΡ Π½Π°ΡΡΠ΄Ρ Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΠΈ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ Π½Π° ΡΠΎΠ½Π΅ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΡΡΠΎΡΠΆΠ΅Π½ΠΈΡ ΡΠ²Π»ΡΡΡΡΡ ΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ, ΡΠ½ΠΈΠΆΠ°ΡΡΠΈΠΌΠΈ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΈ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΆΠΈΠ·Π½ΠΈ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ
ΠΈ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-Π»Π΅Π³ΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°ΡΡΠΈΠΌΠΈ ΡΠ°ΡΡΠΎΡΡ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΉ. Π ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΡΠΈΠΎΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π»Π΅ΠΆΠΈΡ ΠΊΠΎΠ½ΡΠ°ΠΊΡΠ½ΠΎΠ΅ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΡΠ΅Π·Π²ΡΡΠ°ΠΉΠ½ΠΎ Π½ΠΈΠ·ΠΊΠΈΡ
ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡ Π½Π° ΠΎΡΠ³Π°Π½Ρ ΠΈ ΡΠΊΠ°Π½ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΊΡΠΈΠΎΠ·ΠΎΠ½Π΄Π°. Π Π΄Π°Π½Π½ΠΎΠΉ ΡΡΠ°ΡΡΠ΅ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΠ΅ΡΡΡ ΠΎΠΏΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΡΠΈΠΎΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Ρ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ
ΠΈ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-Π»Π΅Π³ΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°
ΠΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΠΊΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΡΠ΅Π½ΠΎΠ·Π° ΡΡΠ°Ρ Π΅ΠΈ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ Π±ΡΠΎΠ½Ρ ΠΎΡΠΊΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ Ρ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠ° Π΄ΠΎΠ½ΠΎΡΡΠΊΠΈΡ Π»Π΅Π³ΠΊΠΈΡ (ΠΏΠ΅ΡΠ²ΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π² Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ)
Lung transplantation is the final treatment option for end-stage lung failure. In 2019, 63,530 lung transplants wereΒ performed worldwide [13]. Due to the variety of diseases causing patients to resort to lung transplant surgeries,Β there is a wide range of different complications and conditions that are subject to an individual clinical approachΒ to determine treatment tactics. Each case is of great clinical interest due to the small amount of these operationsΒ and the complexity of postoperative rehabilitation, which requires a multidisciplinary approach [12]. We present aΒ report on a surgical treatment of expiratory tracheal stenosis in combination with bronchiectasis in a lung recipient.Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ Π»Π΅Π³ΠΊΠΈΡ
β Π΅Π΄ΠΈΠ½ΡΡΠ²Π΅Π½Π½ΡΠΉ ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ Π»Π΅ΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π»Π΅Π³ΠΊΠΈΡ
Π² ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉΒ ΡΡΠ°Π΄ΠΈΠΈ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ. Π 2019 Π³ΠΎΠ΄Ρ Π² ΠΌΠΈΡΠ΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΎ 63 530 ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΉ Π»Π΅Π³ΠΊΠΈΡ
[13].Β Π ΡΠΈΠ»Ρ ΠΌΠ½ΠΎΠ³ΠΎΠΎΠ±ΡΠ°Π·ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡΠΈΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΊ ΠΏΠ΅ΡΠ΅ΡΠ°Π΄ΠΊΠ΅ Π»Π΅Π³ΠΊΠΈΡ
, ΡΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ ΡΠΈΡΠΎΠΊΠΈΠΉΒ ΡΠΏΠ΅ΠΊΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ ΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠΎΠ΄Π»Π΅ΠΆΠ°Ρ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎΠΌΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΡΒ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠ°ΠΊΡΠΈΠΊΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ. ΠΠ°ΠΆΠ΄ΡΠΉ ΡΠ»ΡΡΠ°ΠΉ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΠΎΠ³ΡΠΎΠΌΠ½ΡΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΡΠΊΠΈΒ Π·ΡΠ΅Π½ΠΈΡ Π² ΡΠΈΠ»Ρ Π½Π΅Π±ΠΎΠ»ΡΡΠΎΠ³ΠΎ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π΄Π°Π½Π½ΡΡ
ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΉ ΠΈ ΡΠ»ΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ,Β ΡΡΠ΅Π±ΡΡΡΠ΅ΠΉ ΠΌΡΠ»ΡΡΠΈΠ΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° [12]. ΠΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅ΠΌΒ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠΊΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΡΠ΅Π½ΠΎΠ·Π° ΡΡΠ°Ρ
Π΅ΠΈ Π²Β ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ Π±ΡΠΎΠ½Ρ
ΠΎΡΠΊΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°Β ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π»Π΅Π³ΠΊΠΈΡ
Open laryngectomy: Clinical experience
Introduction. The problem of treatment and rehabilitation of patients with laryngeal cancer has been a complicated and controversial one.Important conditions for selection of the type and scale of functionally sparing surgical intervention are accurate preoperative diagnosis of advancement of the tumor and oncological appropriateness of the intervention. Currently, the problem of single-step reconstruction of lost laryngeal functions after organ-preserving surgeries remains open. For this purpose, researchers use both auto-/homografts and endoprosthetics made of various materials. In some cases, endoprosthetics in lyrengectomy didnβt allow to restore laryngeal lumen due to granulation tissue, cicatricial stenosis, laryngotracheomalacia.The study objective is to increase treatment and rehabilitation effectiveness in patients with laryngeal cancer after open laryngectomy.Materials and methods. Our experience is based on open laryngectomies in 86 patients performed at the Clinical Oncology Dispensary No. 1 of the Moscow Healthcare Department in the period from 2011 to 2014. Primary laryngeal cancer was diagnosed in 84 (97.7 %) patients, recurrent laryngeal cancer after a full course of radiation therapy β in 2 (2.3 %) patients. Vertical laryngectomy was performed in 74 patients, horizontal β in 12 patients.Vertical laryngectomies were performed for tumors located near the vocal and vestibular flaps, anterior commissure, subglottis, laryngeal sinus;horizontal for tumors located near the epiglottis, vestibular flaps, vallecula, root of the tongue if arytenoids were intact and vocal cords were mobile. In the postoperative period, an important factor was restoration of the organβs function through early rehabilitation of respiratory, vocal, and protective functions. Evaluation of the laryngeal lumen was performed using endoscopic examination. Any diagnosed ligatures, granulation tissue, scars were resected. Prior to decannulation, ultrasound examination of the larynx was performed. Effectiveness of vocal function restoration was evaluated using computer acoustic analysis of the voice.Results. Restoration of the lost laryngeal functions after organ-preserving open laryngectomies in patients with laryngeal cancer is achieved through reconstruction of the remaining parts of the organ, formation of an adequate lumen for breathing through postoperative endoscopic correction, and early rehabilitation of respiratory, vocal, and protective function.Conclusion. Open laryngectomies with restoration of the remaining parts and single-step reconstruction of the lumen with an endoprosthesis, as well as subsequent combined treatment, allowed to restore respiratory function in 93.1 % patients, vocal function β in 91.9 % patients