112 research outputs found
Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice
SummaryDegeneration of dopamine (DA) neurons in Parkinson’s disease (PD) causes hypokinesia, but DA replacement therapy can elicit exaggerated voluntary and involuntary behaviors that have been attributed to enhanced DA receptor sensitivity in striatal projection neurons. Here we reveal that in hemiparkinsonian mice, striatal D1 receptor-expressing medium spiny neurons (MSNs) directly projecting to the substantia nigra reticulata (SNr) lose tonic presynaptic inhibition by GABAB receptors. The absence of presynaptic GABAB response potentiates evoked GABA release from MSN efferents to the SNr and drives motor sensitization. This alternative mechanism of sensitization suggests a synaptic target for PD pharmacotherapy
A pilot study investigating the potential of stable isotope research of 13th-18th century human remains from the St. Catherine's church in Eindhoven, the Netherlands
Projectnr.: 2009-2
Archeologisch bureauonderzoek en inventariserend veldonderzoek door middel van boringen Oostzaan Noordeinde 68 (IVO-O), gemeenmte Oostzaan
Archeologisch bureauonderzoek en inventariserend veldonderzoek door middel van boringen op Haarweg 127 te Gorinchem, gemeente Gorinchem
Inventariserend veldonderzoek (IVO-O) door middel van boringen in de Woudpolder te Krommeniedijk, gemeente Zaanstad.
Archeologisch bureauonderzoek en inventariserend veldonderzoek (IVO) Kerkpad 7 te Krabbendam, gemeente Harenkarsel
Archeologische begeleiding protocol opgraven (AB) van de graafwerkzaamheden op de Raaks te Haarlem
Inventarisrend veldonderzoek door middel van boringen en een archeologische begeleiding op de Kinderhuisvest 47 te Haarlem
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