Estimation of surface potential of lymphocytes from patients with leukemia using kelvin probe mode

The feasibilities of the Kelvin probe mode were shown to estimate a surface potential of lympho cytes from the patients with leukemia. Having compared the values of the surface potential obtained by the traditional method of microelectrophoresis and by the Kelvin probe mode, it was established that the use of the atomic force microscope made it possible to obtain data which were of specified diagnostic importance while studying lymphocyte functional status at different stages in leucopoiesis and indicated progression of the pathological proces

Changes of the biophysical properties of blood corpuscles from the elderly under mechanical stress in vitro

Features of biophysical properties in blood cells from the elderly under mechanical stress applied in vitro have been studied. This stress was reported to trigger the signaling pathway engaged by purinergic receptor activation. The stiffness of the cell surfaces of red blood cells, granulocytes, lymphocytes, and platelets decreased, and the surface potential became more positive. Our findings add to the knowledge of the effect of mechanical deformation on leukocytes and platelets, which are the key regulators of homeostatic processes in the microvasculature, and on red blood cells involved in the regulation of vascular tone in arterioles and tissue oxygenation in the elderl

The Gnevyshev Gap Effect in Galactic Cosmic Rays

Abstract During the last three solar cycles and in a wide energy range of galactic cosmic rays both the modulation and the variability of the intensity demonstrate effects related to the Gnevyshev Gap (GG) -a substantial decrease once or twice during the maximum phase of each solar cycle of a parameter that generally varies in phase with the cycle. The GG-effect also manifests itself in the behaviour of both the strength of the average interplanetary magnetic field and the power of its fluctuating component. The energy dependence of the GGeffect in the modulation and in the variability of the cosmic ray intensity was found to be different. The start of the GG-effect in the cosmic ray modulation practically coincides with a change in the energy dependence of the cosmic ray modulation

Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-ligand pathway in mice

Peer reviewedPublisher PD