2 research outputs found
A Potential New Threat to Wild Life: Presence of UV Filters in Bird Eggs from a Preserved Area
The present study uses bird eggs
of seven wild species as a biomonitoring
tool for sunscreens occurrence. Seven UV filters (UV-Fs), including
3 hydroxy-metabolites of oxybenzone (benzophenone 3, BP3) were characterized
in unhatched eggs from Doñana Natural Space (Spain). High frequency
of detection was observed for all UV-Fs, ranging from 95% to 100%.
The oxybenzone metabolite 4-hydroxybenzophenone (4HB) was ubiquitous
at concentrations in the range 12.0–3348 ng g<sup>–1</sup> dry weight (dw). The parent compound, oxybenzone, was also present
in all samples at lower concentrations (16.9–49.3 ng g<sup>–1</sup> dw). Due to the three BP3′s metabolites, benzophenone
1 (BP1), 4HB, and 4,4′-dihydroxybenzophenone (4DHB) presence
in unhatched eggs, it can be inferred that parent compounds are absorbed
into the bird through the upper gut and the OH-derivatives formed
are transferred by the mother to the egg before the lying. White stork
(<i>Ciconia ciconia</i>) and western marsh harrier (Circus
aeruginosus) were the most contaminated species, with mean total UV-Fs
concentrations of 834 and 985 ng g<sup>–1</sup> dw, respectively.
Results evidenced that biomagnification process across the bird species
studied cannot be ruled out
Structural Elucidation of Sulfaquinoxaline Metabolism Products and Their Occurrence in Biological Samples Using High-Resolution Orbitrap Mass Spectrometry
Four
previously unreported metabolism products of sulfaquinoxaline
(SQX), a widely used veterinary medicine, were isolated and analyzed
using liquid chromatography coupled to high-resolution Orbitrap mass
spectrometry. Metabolites were structurally elucidated, and a fragmentation
pathway was proposed. The combination of high-resolution MS<sup>2</sup> spectra, linear ion trap MS<sup>2</sup>, in-source collision-induced
dissociation (CID) fragmentation, and photolysis were used to analyze
SQX and its metabolites. All metabolism products identified showed
a similar fragmentation pattern to that of the original drug. Differential
product ions were produced at <i>m</i>/<i>z</i> 162 and 253 which contain the radical moiety with more 16 Da units
than sulfaquinoxaline. This occurs by a hydroxyl attachment to the
quinoxaline moiety. With the exception of two low-intensity compounds,
all the mass errors were below 5.0 ppm. The distribution of these
metabolites in some animal species are also presented and discussed