Regioselective synthesis, antitumor and antioxidant activities of some 1,2,4-triazole derivatives based on 4-phenyl-5-(quinolin-8-yloxy)methyl-4<i>H</i>-1,2,4-triazole-3-thiol

<p></p> <p>Regioselective synthesis of some triazole derivatives <b>4–18</b> was achieved from the versatile, readily accessible 4-phenyl-5-(quinolin-8-yloxy)methyl-4<i>H</i>-1,2,4-triazole-3-thiol/thione <b>3.</b> The structures of the newly synthesized products were confirmed and characterized by IR, ¹H NMR, ¹³C NMR, and mass spectral studies. Most of the synthesized compounds were evaluated for their antitumor and antioxidant activities and demonstrated potent to weak activities.</p