955 research outputs found
Photon polarization entanglement induced by biexciton: experimental evidence for violation of Bell's inequality
We have investigated the polarization entanglement between photon pairs
generated from a biexciton in a CuCl single crystal via resonant hyper
parametric scattering. The pulses of a high repetition pump are seen to provide
improved statistical accuracy and the ability to test Bell's inequality. Our
results clearly violate the inequality and thus manifest the quantum
entanglement and nonlocality of the photon pairs. We also analyzed the quantum
state of our photon pairs using quantum state tomography.Comment: 4 pages, 5 figure
Quantum diffraction and interference of spatially correlated photon pairs and its Fourier-optical analysis
We present one- and two-photon diffraction and interference experiments
involving parametric down-converted photon pairs. By controlling the divergence
of the pump beam in parametric down-conversion, the diffraction-interference
pattern produced by an object changes from a quantum (perfectly correlated)
case to a classical (uncorrelated) one. The observed diffraction and
interference patterns are accurately reproduced by Fourier-optical analysis
taking into account the quantum spatial correlation. We show that the relation
between the spatial correlation and the object size plays a crucial role in the
formation of both one- and two-photon diffraction-interference patterns.Comment: 10 pages, 13 figures, rev.
Relaxing a constraint on the number of messengers in a low-scale gauge mediation
We propose a mechanism for relaxing a constraint on the number of messengers
in low-scale gauge mediation models. The Landau pole problem for the
standard-model gauge coupling constants in the low-scale gauge mediation can be
circumvented by using our mechanism. An essential ingredient is a large
positive anomalous dimension of messenger fields given by a large Yukawa
coupling in a conformal field theory at high energies. The positive anomalous
dimension reduces the contribution of the messengers to the beta function of
the standard-model gauge couplings.Comment: 22pages; v2:explanations expanded in sec.3.2, reference adde
Four-Photon Quantum Interferometry at a Telecom Wavelength
We report the experimental demonstration of four-photon quantum interference
using telecom-wavelength photons. Realization of multi-photon quantum
interference is essential to linear optics quantum information processing and
measurement-based quantum computing. We have developed a source that
efficiently emits photon pairs in a pure spectrotemporal mode at a telecom
wavelength region, and have demonstrated the quantum interference exhibiting
the reduced fringe intervals that correspond to the reduced de Broglie
wavelength of up to the four photon `NOON' state. Our result should open a path
to practical quantum information processing using telecom-wavelength photons.Comment: 4 pages, 4 figure
Static black hole uniqueness and Penrose inequality
Under certain conditions, we give a new way to prove the uniqueness of static
black hole in higher dimensional asymptotically flat spacetimes. In the proof,
the Penrose inequality plays a key role in higher dimensions as well as four
dimensions.Comment: 6 page
Explicit Form of the Evolution Operator of Tavis-Cummings Model : Three and Four Atoms Cases
In this letter the explicit form of evolution operator of the Tavis-Cummings
model with three and four atoms is given. This is an important progress in
quantum optics or mathematical physics.Comment: Latex file, 10 pages. We combined quant-ph/0404034(the three atoms
case) and quant-ph/0406184(the four atoms case) into an article. to appear in
International Journal of Geometric Methods in Modern Physic
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Clinical correlates of blood-derived circulating tumor DNA in pancreatic cancer.
BackgroundTreatment outcomes for patients with advanced pancreatic ductal adenocarcinoma (PDAC) remain dismal. There are unmet needs for understanding the biologic basis of this malignancy using novel next-generation sequencing technologies. Herein, we investigated the clinical utility of circulating tumor DNA (ctDNA) (the liquid biopsy) in this malignancy.MethodsctDNA was analyzed in 112 patients with PDAC (54-73 genes) and tissue DNA in 66 patients (315 genes) (both clinical-grade next-generation sequencing). Number of alterations, %ctDNA, concordance between ctDNA and tissue DNA, and correlation of ctDNA results with survival were assessed.ResultsThe most common genes altered in ctDNA were TP53 (46% of patients, N = 51) and KRAS (44%, N = 49). Median number of characterized ctDNA alterations per patient was 1 (range, 0-6), but patients with advanced PDAC had significantly higher numbers of ctDNA alterations than those with surgically resectable disease (median, 2 versus 0.5, P = 0.04). Overall, 75% (70/94) of advanced tumors had ≥ 1 ctDNA alteration. Concordance rate between ctDNA and tissue DNA alterations was 61% for TP53 and 52% for KRAS. Concordance for KRAS alterations between ctDNA and tissue DNA from metastatic sites was significantly higher than between ctDNA and primary tumor DNA (72% vs 39%, P = 0.01). Importantly, higher levels of total %ctDNA were an independent prognostic factor for worse survival (hazard ratio, 4.35; 95% confidence interval, 1.85-10.24 [multivariate, P = 0.001]). A patient with three ctDNA alterations affecting the MEK pathway (GNAS, KRAS, and NF1) attained a response to trametinib monotherapy ongoing at 6 months.ConclusionsOur findings showed that ctDNA often harbored unique alterations some of which may be targetable and that significantly greater numbers of ctDNA alterations occur in advanced versus resectable disease. Furthermore, higher ctDNA levels were a poor prognostic factor for survival
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Genomic Assessment of Blood-Derived Circulating Tumor DNA in Patients With Colorectal Cancers: Correlation With Tissue Sequencing, Therapeutic Response, and Survival.
PurposeGenomic alterations in blood-derived circulating tumor DNA (ctDNA) from patients with colorectal cancers were correlated with clinical outcomes.Patients and methodsNext-generation sequencing of ctDNA (54- to 73-gene panel) was performed in 94 patients with colorectal cancer.ResultsMost patients (96%) had metastatic or recurrent disease at the time of blood draw. The median number of nonsynonymous alterations per patient was three (range, zero to 30). The most frequently aberrant genes were TP53 (52.1% of patients), KRAS (34%), and APC (28.7%). Concordance between tissue and blood next-generation sequencing ranged from 63.2% (APC) to 85.5% (BRAF). Altogether, 74 patients (79%) had one or more nonsynonymous alterations, 69 (73%) had one or more potentially actionable alterations, and 61 (65%) had an alteration actionable by a drug approved by the US Food and Drug Administration (on or off label). Lung metastases correlated with improved survival from diagnosis in univariable analysis. ctDNA of 5% or more from blood tests as well as EGFR and ERBB2 (HER2) nonsynonymous alterations correlated with worse survival (but only ERBB2 remained significant in multivariable analysis). No two patients had identical molecular portfolios. Overall, 65% versus 31% of patients treated with matched (n = 17) versus unmatched therapy (n = 18) after ctDNA testing achieved stable disease for 6 months or more, partial response, or complete response (P = .045); progression-free survival, 6.1 versus 2.3 months (P = .08); and survival not reached versus 9.4 months (P = .146; all by multivariable analysis).ConclusionPatients with colorectal cancer have heterogeneous ctDNA profiles, and most harbor potentially actionable ctDNA alterations. Matched therapy yielded higher rates of stable disease for 6 months or more, partial response, or complete response. ctDNA assessment may have clinical utility and merits further investigation
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