Study of acute and subacute action of iron-molybdenum nanocluster polyoxometalates

There were no significant deviations from the norm in the functional state of the liver, kidneys, and pancreas in the study of the acute toxicity of iron-molybdenum buckyballs intended for targeted drug delivery. No accumulation of nanoparticles or deviation from the norm in any investigated parameter was detected in the study of subacute toxicity. © 2013 Pleiades Publishing, Ltd

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

The paper discusses the results of a research on physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs), which show promise in the field of biomedicine as a means of targeted drug delivery, including the transport to immune privileged organs. POMs can be considered as components of releasing systems, including the long-acting ones with feedback (for controlling the drug active component release rate). POMs are promising drugs for the treatment of anemia. Also, the paper deals with the results of studies of POM effect on living systems at the molecular and cellular levels, at that of individual organs, and on the organism as a whole. The mechanism and kinetics of POM destruction and possibilities of stabilization, the oscillatory phenomena manifestation, the formation of POM conjugates with bioactive substances which can be released during the destruction of POM, with polymer components, and with indicator fluorescent dyes, as well as forecasts for further research, are considered. © 2021, ITMO University. All rights reserved.The paper was prepared in the framework of implementation of the State Assignment from the Ministry of Education and Science of the Russian Federation (Projects Nos. AAAA-A20-120061990010-7 (FEUZ-2020-0052) and AAAA-A18-118020590107-0), as well as of the Program for Increasing Competitiveness of UrFU (financially supported according to the Decree No. 211 of the Government of the Russian Federation, Contract No. 02.A03.21.0006). The research aimed at creating the long-time drug release systems with feedback was carried out within the framework of the project of the Russian Science Foundation No. 19-73-00177

Studying of safety of molybden nanocluster polyoxometalates intended for address delivery of medicinal substances

The chemical structure of buckyballs on a basis of polyoxometalates defines possibility of their use in quality nanocarriers for carrying over of medical products to the damaged fabrics. Buckyballs on the basis of molybdenum stability research is carried out in liquids with various pH, and also studying of their toxicity and accumulation after introduction in an organism. It is revealed that buckyballs on the basis of molybdenum possess low accumulation and high toxicity in relation to hepatocytes that is shown increase in an index of alteration of the last, damage microcirculation liver channels.Химическая структура букиболов на основе полиоксометаллатов определяет возможность их использования в качестве наноконтейнеров для переноса лекарственных средств в поврежденные ткани. Проведено исследование устойчивости букиболов на основе молибдена в жидкостях с различными pH, а также изучение их токсичности и кумулятивности при введении в организм. Обнаружено, что букиболы на основе молибдена обладают низкой кумулятивностью и высокой токсичностью по отношению к гепатоцитам, что проявляется в увеличении индекса альтерации последних, повреждении микроциркуляторного русла печени

Investigation of chronical toxicity of molybdenum and iron-molybdenum nanocluster polyoxometallates

It was conducted research of chronical toxicity of nanocluster polyoxometallates with type structure of buckyball (fullerene) intended for address delivery of medicines in an organism. Absence of accumulation of molybdenum in an organism of rats was established at daily intramuscular introduction of water solutions of both preparations within a month. On the basis of the analysis of biochemical tests and indicators of peripheral blood essential decrease in toxicity iron- molybdenum buckyballs in comparison with molybdenum ones was revealed (there was absence of an inflammation, cytolysis and infringements of a functional condition of bodies at chronic action iron- molybdenum polyoxometallates).Проведено исследование хронической токсичности нанокластерных полиоксометаллатов со структурой типа букибола (фуллерена), предназначенных в качестве средств адресной доставки лекарственных веществ в организме. Установлено отсутствие аккумулирования молибдена в организме крыс при ежедневном внутримышечном введении водных растворов обоих препаратов в течение месяца. На основании анализа биохимических тестов и показателей периферической крови выявлено существенное снижение токсичности железо-молибденовых букиболов по сравнению с молибденовыми (отсутствие воспаления, цитолиза и нарушения функционального состояния органов при хроническом действии железо-молибденовых полиоксометаллатов)

Stability of the Mo72Fe30 polyoxometalate buckyball in solution

The stability of the [Mo 72Fe 30O 252(CH 3COO) 12{Mo 2O 7(H 2O)} 2{H 2Mo 2O 8(H 2O)}(H 2O) 91] · ̃150H 2O polyoxometalate (Mo 72Fe 30) with a buckyball framework structure in solution has been investi- gated as a function of the solute concentration, illuminance, the presence/absence of a polymer, and the acid- ity of the medium. The polyoxometalate ions can form association species with molecules of water-soluble nonionic polymers, such as polyvinyl alcohol and polyvinylpyrrolidone. Electrotransport properties of the polyoxometalate ions-mobility, transport number, and diffusion coefficient-have been measured. The catalytic activity and stability of Mo 72Fe 30 in a redox reaction have been evaluated. © Pleiades Publishing, Ltd., 2012

Electrotransport, sorption, and photochemical properties of nanocluster polyoxomolybdates with a toroidal structure

The electrotransport, sorption, and photochemical properties of polyoxometalate NH 4) 32[M VI 110 M V 28 O 416H 6(H 2O) 58(CH 3CO 2) 6]· xH 2O (x ~ 250) with a toroidal structure are studied. Conditions for studying these characteristics are selected on the basis of data on the stability of POM, in dependence on the concentration and acidity of the medium and the processes of thermal decomposition. A set of independent physical and chemical methods of analysis is used. The possibility of the complexation of toroidal POM with polymer molecules is established. The photostabilizing effect of this POM on polymer molecules is revealed. © Pleiades Publishing, Ltd., 2012

Study of the Stability of Solid Polyoxometalate Mo72Fe30 with a Buckyball Structure

Samples of polyoxometalate Mo 72Fe 30: [Mo 72Fe 30O 252 (CH 3COO) 12{Mo 2O 7 (H 2O)} 2 {H 2Mo 2O 8(H 2O)}(H 2O) 91] · ≈150H 2O with a buckyball structure, which can be both crystalline and amorphous, were synthesized. It was shown that such samples can be studied by neutron diffraction. The stability of Mo 72Fe 30 to heating and UV light exposure (in poly(vinyl alcohol) and polyvinylpyrrolidone films) was studied by IR, EPR, and electronic absorption spectroscopy; thermal analysis; and mass spectrometry. Mo 72Fe 30 was found to be less stable to heating and irradiation in a poly(vinyl alcohol) film as compared with the related polyoxometallate Mo 132 free of iron. The sorption properties of Mo 72Fe 30 to organic vapors and its stability under sorption conditions were studied. It was demonstrated that, in addition to sorption, organic substances cause the destruction of buckyballs. © Pleiades Publishing, Ltd., 2012