Dynamic acoustic field activated cell separation (DAFACS)

Advances in diagnostics, cell and stem cell technologies drive the development of application-specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for highthroughput, label-free, high recovery, cell and particle separation and isolation in regenerative medicine. Here, we demonstrate a novel approach utilizing a dynamic acoustic field that is capable of separating an arbitrary size range of cells. We first demonstrate the method for the separation of particles with different diameters between 6 and 45 μm and secondly particles of different densities in a heterogeneous medium. The dynamic acoustic field is then used to separate dorsal root ganglion cells. The shearless, label-free and low damage characteristics make this method of manipulation particularly suited for biological applications. Advantages of using a dynamic acoustic field for the separation of cells include its inherent safety and biocompatibility, the possibility to operate over large distances (centimetres), high purity (ratio of particle population, up to 100%), and high efficiency (ratio of separated particles over total number of particles to separate, up to 100%)

Formation of Millisecond Pulsars in Globular Clusters

In this contribution we discuss how neutron stars are produced and retained in globular clusters, outlining the most important dynamical channels and evolutionary events that affect thepopulation of mass-transferring binaries with neutron stars and result in the formation of recycled pulsars. We confirm the importance of electron-capture supernovae in globular clusters as the major supplier of retained neutron stars.By comparing the observed millisecond pulsar population and the results obtained from simulations, we discuss several constraints on the evolution of mass-transferring systems.In particular, we find that in our cluster model the following mass-gaining events create populations of MSPs that do not match the observations (with respect to binary periods and companion masses or the number of produced systems) and therefore likely do not lead to NSs spun up to millisecond periods: (i) accretion during a common envelope event with a NS formed through accretion-induced collapse, and (ii) mass transfer from a WD donor. By restricting ourselves to the evolutionary and dynamical paths that most likely lead to neutron star recycling, we obtain good agreement between our models and the numbers and characteristics of observed millisecond pulsars in the clusters Terzan 5 and 47 Tuc.Comment: 6 pages, 3 figures, to appear in the proceedings of the 40 Years of Pulsars conference held at McGill University in August 200

Theory of cooling neutron stars versus observations

We review current state of neutron star cooling theory and discuss the prospects to constrain the equation of state, neutrino emission and superfluid properties of neutron star cores by comparing the cooling theory with observations of thermal radiation from isolated neutron stars.Comment: 9 pages, 4 figures, 3 tables, to appear in the proceedings of "40 Years of Pulsars" held in Montreal, Canada, August 12-17, 2007, eds. C. Bassa, Z. Wang, A. Cumming, V. Kaspi, AIP, in press (v.2 - minor bibliography corrections

Hydrostatic Expansion and Spin Changes During Type I X-Ray Bursts

We present calculations of the spin-down of a neutron star atmosphere due to hydrostatic expansion during a Type I X-ray burst. We show that (i) Cumming and Bildsten overestimated the spin-down of rigidly-rotating atmospheres by a factor of two, and (ii) general relativity has a small (5-10%) effect on the angular momentum conservation law. We rescale our results to different neutron star masses, rotation rates and equations of state, and present some detailed rotational profiles. Comparing with recent observations of large frequency shifts in MXB 1658-298 and 4U 1916-053, we find that the spin-down expected if the atmosphere rotates rigidly is a factor of two to three less than the observed values. If differential rotation is allowed to persist, we find that the upper layers of the atmosphere spin down by an amount comparable to the observed values; however, there is no compelling reason to expect the observed spin frequency to be that of only the outermost layers. We conclude that hydrostatic expansion and angular momentum conservation alone cannot account for the largest frequency shifts observed during Type I bursts.Comment: Submitted to the Astrophysical Journal (13 pages, including 4 figures

SAX J1808.4-3657 in Quiescence: A Keystone for Neutron Star Science

The accreting millisecond pulsar SAX J1808.4-3658 may be a transition object between accreting X-ray binaries and millisecond radio pulsars. We have constrained the thermal radiation from its surface through XMM-Newton X-ray observations, providing strong evidence for neutrino cooling processes from the neutron star core. We have also undertaken simultaneous X-ray and optical (Gemini) observations, shedding light on whether the strong heating of the companion star in quiescence may be due to X-ray irradiation, or to a radio pulsar turning on when accretion stops.Comment: To appear in the proceedings of "Forty Years of Pulsars: Millisecond Pulsars, Magnetars and More" held in Montreal, Canada, August 12-17, 2007. 4 page

The rp Process Ashes from Stable Nuclear Burning on an Accreting Neutron Star

We calculate the nucleosynthesis during stable nuclear burning on an accreting neutron star. This is appropriate for weakly magnetic neutron stars accreting at near-Eddington rates in low mass X-ray binaries, and for most accreting X-ray pulsars. We show that the nuclear burning proceeds via the rapid proton capture process (rp process), and makes nuclei far beyond the iron group. The final mixture of nuclei consists of elements with a range of masses between approximately A=60 and A=100. The average nuclear mass of the ashes is set by the extent of helium burning via (alpha,p) reactions, and depends on the local accretion rate. Our results imply that the crust of these accreting neutron stars is made from a complex mixture of heavy nuclei, with important implications for its thermal, electrical and structural properties. A crustal lattice as impure as our results suggest will have a conductivity set mostly by impurity scattering, allowing more rapid Ohmic diffusion of magnetic fields than previously estimated.Comment: To appear in the Astrophysical Journal (33 pages, LaTeX, including 11 postscript figures

Periodic Thermonuclear X-ray Bursts from GS 1826-24 and the Fuel Composition as a Function of Accretion Rate

We analyze 24 type I X-ray bursts from GS 1826-24 observed by the Rossi X-ray Timing Explorer between 1997 November and 2002 July. The bursts observed between 1997-98 were consistent with a stable recurrence time of 5.74 +/- 0.13 hr. The persistent intensity of GS 1826-24 increased by 36% between 1997-2000, by which time the burst interval had decreased to 4.10 +/- 0.08 hr. In 2002 July the recurrence time was shorter again, at 3.56 +/- 0.03 hr. The bursts within each epoch had remarkably identical lightcurves over the full approx. 150 s burst duration; both the initial decay timescale from the peak, and the burst fluence, increased slightly with the rise in persistent flux. The decrease in the burst recurrence time was proportional to Mdot^(-1.05+/-0.02) (where Mdot is assumed to be linearly proportional to the X-ray flux), so that the ratio alpha between the integrated persistent and burst fluxes was inversely correlated with Mdot. The average value of alpha was 41.7 +/- 1.6. Both the alpha value, and the long burst durations indicate that the hydrogen is burning during the burst via the rapid-proton (rp) process. The variation in alpha with Mdot implies that hydrogen is burning stably between bursts, requiring solar metallicity (Z ~ 0.02) in the accreted layer. We show that solar metallicity ignition models naturally reproduce the observed burst energies, but do not match the observed variations in recurrence time and burst fluence. Low metallicity models (Z ~ 0.001) reproduce the observed trends in recurrence time and fluence, but are ruled out by the variation in alpha. We discuss possible explanations, including extra heating between bursts, or that the fraction of the neutron star covered by the accreted fuel increases with Mdot.Comment: 9 pages, 6 figures, accepted by ApJ. Minor revisions following the referee's repor

Mitigation of Moral Hazard and Adverse Selection in Venture Capital Financing: The Influence of the Country’s Institutional Setting

A venture capitalist (VC) needs to trade off benefits and costs when attempting to mitigate agency problems in their investor-investee relationship. We argue that signals of ventures complement the VC’s capacity to screen and conduct a due diligence during the pre-investment phase, but its attractiveness may diminish in institutional settings supporting greater transparency. Similarly, whereas a VC may opt for contractual covenants to curb potential opportunism by ventures in the post-investment phase, this may only be effective in settings supportive of shareholder rights enforcement. Using an international sample of VC contracts, our study finds broad support for these conjectures. It delineates theoretical and practical implications for how investors can best deploy their capital in different institutional settings whilst nurturing their relationships with entrepreneurs

Machine Learning Models that Remember Too Much

Machine learning (ML) is becoming a commodity. Numerous ML frameworks and services are available to data holders who are not ML experts but want to train predictive models on their data. It is important that ML models trained on sensitive inputs (e.g., personal images or documents) not leak too much information about the training data. We consider a malicious ML provider who supplies model-training code to the data holder, does not observe the training, but then obtains white- or black-box access to the resulting model. In this setting, we design and implement practical algorithms, some of them very similar to standard ML techniques such as regularization and data augmentation, that "memorize" information about the training dataset in the model yet the model is as accurate and predictive as a conventionally trained model. We then explain how the adversary can extract memorized information from the model. We evaluate our techniques on standard ML tasks for image classification (CIFAR10), face recognition (LFW and FaceScrub), and text analysis (20 Newsgroups and IMDB). In all cases, we show how our algorithms create models that have high predictive power yet allow accurate extraction of subsets of their training data

Models of Type I X-ray Bursts from GS 1826-24: A Probe of rp-Process Hydrogen Burning

The X-ray burster GS 1826-24 shows extremely regular Type I X-ray bursts whose energetics and recurrence times agree well with thermonuclear ignition models. We present calculations of sequences of burst lightcurves using multizone models which follow the rp-process nucleosynthesis with an extensive nuclear reaction network. The theoretical and observed burst lightcurves show remarkable agreement. The models naturally explain the slow ~5s rise and long ~100s tails of these bursts, as well as their dependence on mass accretion rate. This comparison provides further evidence for solar metallicity in the accreted material in this source, and constrains the distance to the source. The main difference is that the observed lightcurves do not show the distinct two-stage rise of the models. This may reflect the time for burning to spread over the stellar surface, or may indicate that our treatment of heat transport or nuclear physics needs to be revised. The trends in burst properties with accretion rate are well-reproduced by our spherically symmetric models which include chemical and thermal inertia from the ashes of previous bursts. Changes in the covering fraction of the accreted fuel are not required.Comment: 5 pages, 4 figures, to appear in ApJ letter