37 research outputs found
Comparative study of sustained-release lipid microparticles and solid dispersions containing ibuprofen
Antibody-Mediated âUniversalâ Osteoclast Targeting Platform using Calcitonin as a Model Drug
Fizikokemijska karakterizacija Ävrstih disperzijskih sustava tadalafila s poloksamerom 407
Dissolution behaviour of a poorly water-soluble drug, tadalafil, from its solid dispersion systems with poloxamer 407 has been investigated. Solid dispersion systems of tadalafil were prepared with poloxamer 407 in 1:0.5, 1:1.5 and 1:2.5 ratios using the melting method. Characterization of binary systems with FTIR and powder XRPD studies demonstrated the presence of strong hydrogen bonding interactions, a significant decrease in crystallinity and the possibility of existence of amorphous entities of the drug. In the binary systems tested, 1:0.5 proportion of tadalafil/poloxamer 407 showed rapid dissolution of tadalafil (DE30 70.9 ± 3.6 %). In contrast, higher proportions of poloxamer 407 (1:1.5 and 1:2.5) offered no advantage towards dissolution enhancement of the drug from corresponding binary systems indicating altered rheological characteristics of the polymer, at its higher concentration, which might have retarded the release rate of tadalafil.U radu je ispitivano oslobaÄanje u vodi teĆĄko topljivog lijeka tadalafila iz Ävrstih disperzijskih sustava. Ti sustavi pripravljeni su s poloksamerom 407 u omjeru lijeka i polimera 1:0,5, 1:1,5 i 1:2,5, koristeÄi metodu taljenja. Karakterizacija binarnih sustava s FTIR i rendgenskom difrakcijom praha XRD ukazuje na prisutnost snaĆŸnih vodikovih veza, znaÄajno smanjenje kristaliniÄnosti i moguÄu prisutnost amorfnog lijeka. Iz binarnog sustava tadalafil/poloksamer 1:0,5 oslobaÄanje ljekovite tvari je brzo (DE30 70,9 ± 3,6 %). Nasuprot tome, iz pripravaka s viĆĄim omjerima lijeka i polimera (1:1,5 i 1:2,5) oslobaÄanje ljekovite tvari nije poveÄano. Usporavanje oslobaÄanja tadalafila moglo bi biti posljedicom promjene reoloĆĄkih svojstava polimera pri viĆĄim koncentracijama