Opportunities proteomic the analysis of fibers of urine for an estimation of progressing of a chronic heart failure

Purpose: To reveal, what changes of fibers of a pattern of urine at sick are connected by a chronic heart failure (CHF) with increase of a functional class (FC) of disease.Materials and Methods: 90 patients with CHF II-IV FC are surveyed. Control group practically healthy 30 patients. Differentiated allocation separate proteins and fibers of urine of patients made by means of weights-spectrometry.Results: At patients CHF in structure of fibers of urine markers of alteration of kidneys, connected with structural transformation. Progressing CHF up to a final stage it is connected with increase of occurrence β-sarcoglican, similar to tolloids fiber 2 and L-antigen. Among contracting fibers in process of increase FC CHFoccurrence cation-transport ATP decreases, and isoforms 1 fiber 6, connected with microtubuls – raises, that causes reduction of activity of receipt of calcium in sarcoplasmic rethiculum in nephrocytes and endoteliocytes vessels of kidneys.Summary: Changes of an albuminous spectrum of urine at patients CHF it is information are significant for the forecast of progressing of a basic disease

Place of Sulodexide in the Renoprotektivе Therapy of Patients with Chronic Kidney Disease

The problem of chronic kidney disease is not only medical but also social and economic importance. Since these diseases annually kill millions and lead to severe complications associated not only with disability but also the need for high-cost treatment.Therefore, an important aspect of therapy in patients with chronic kidney disease is to prevent development and progression of renal failure. Consequently, a major focus of prevention is to conduct renoprotektivе therapy. In connection with what is necessary to develop new therapies aimed at the basic pathophysiological mechanisms of development of nephropathy. One of the new directions of development in renoprotektivе therapy is the use of the drug in the practice of Sulodexide. Considering the basic properties of the drug, currently based on the Nephrology department conducted a clinical study of the properties of Sulodexide and already received the first clinical cases of the positive effect of the therapy Sulodexide. Consequently, we can already assume that this drug has renoprotektivе action

Screeing of Patients with Essential Hypertension as a Prevention Method Hypertensive Nephropathy

The pathogenesis of secondary hyperparathyreosis (SH) is based on three links. First, that may be a decrease of ionize calcium level and a rise of phosphorous level. Second, that may be a diminution of calcitriolґs synthesis. Third, and just as important as the other two, that may be a decrease of calcitriolґs effect for work of parathyreoid glands.The clinical presentation include kidney disease clinical manifestation, ostoedystrophies, metastatic calcification of tissues and vessels, pruritus and pseudogoat syndrome.The most important laboratory and instrumental diagnostic criterions are: the level of parathyrin, calcium, calcitriol, phosphorous; ultrasonic scanning, computer tomography, scintigraphy of parathyreoid glands; bone’s X-ray examination and densitometry.Prevention and treatment of SH presuppose hypophosphatic ration, phosphatbinders, vitamin D and him active metabolites and calcimimetics.The Rostov Center of Hyperparathyreosis was found in 01. September. 2010 in the nephrologic department of the Rostov State Medical University. The main of the centerґs work is to render specialized competent medical aid to patients with nephrology diseases, which associated with supersecretion of parathormone and resulting complications

Screeing of Patients with Essential Hypertension as a Prevention Method Hypertensive Nephropathy

Purpose: To determine prevalence and evaluate the risk of hypertensive nephropathy in patients with hypertension.Materials and Methods: Based on the city polyclinic № 16 Rostov-on-Don and the Center for Restorative Medicine and Rehabilitation, the mines was carried out screening of patients with hypertension. The study included 330 hypertensive patients without chronic kidney disease in history, of which 303 (91.8%) patients were male, 27 (8.2%) patients – women.Results: It was found that not all clinical and laboratory parameters are affecting the risk of kidney damage in patients with high blood pressure.Summary: Hypertension leads to irreversible renal disorders, assessment of risk is an integral part of the MT treatment activities conducted in these patients

Rehabilitation after COVID-19. Resolution of the International Expert Council of the Eurasian Association of Therapists and the Russian Society of Cardiology

By the middle of 2021, the official global number of coronavirus disease 2019 (COVID-19) patients was close to 230 million, but the number accounting for asymptomatic patients was much higher. Consequences and rehabilitation after COVID-19 are of particular interest and raise many controversial and unresolved issues. On May 18, 2021, the Eurasian Association of Therapists organized an international panel of experts to analyze challenges associated with the post-COVID-19 period. This panel aimed to develop approaches to identify gaps in the discussed issues. This interdisciplinary team of leading experts reviewed the current literature and presented their data to formulate practical guidance on management of patients after COVID-19. The panel of experts also presented recommendations on how to implement the gained knowledge into health care practices

Sodium-glucose co-transporter-2 inhibitors in heart failure and chronic kidney disease: the role of empagliflozin

The development of chronic kidney disease (CKD) is a risk factor not only for cardiovascular diseases, but also for heart failure (HF). This article is a literary review on the use of Sodium-glucose co-transporter-2 (NGLT2) inhibitors in patients with CKD and HF. The paper describes in detail the action of NGLT2 inhibitors in the light of nephro- and cardioprotection. In addition to the glucosuric effect of NGLT2 inhibitors, they have a natriuretic and diuretic effect. One of the effects of NGLT2 inhibitors is the ability to lower blood pressure. One of the key effects of NGLT2 inhibitors, explaining nephroprotection, is the influence on glomerular filtration. The ability of NGLT2 inhibitors to suppress the peroxidation in mitochondria of proximal tubular epithelium was shown. Another putative mechanism of the organ protection action of NGLT2 inhibitors is their ability to inhibit the activation of the sympathetic nervous system.The results of studies using empagliflozin in HF and CKD are presented. In particular, the EMPA-REG OUTCOME study showed that in patients with type 2 diabetes and concomitant cardiovascular diseases, empagliflozin led to a 35% decrease in hospitalization risk due to decompensated HF and decrease of cardiovascular death risk by 38% regardless of baseline renal function. According to the EMPEROR-Reduced study, empagliflozin showed a favorable safety profile

MECHANISMS OF RENAL SCARING FROM REFLUX-NEPHROPATHY

There is presentation of paths of the pathogenesis of renal scaring from vesico-ureteral reflux at this article. Author demonstrated the role of macrophage and tissue monocyte in process of the inflammatory remodeling of interstitial renal tissue. Different cell signals affects interstitial tissue and activates fibroblast ploliferation and interstitial volume increasing. Cytokines such us monocyte chemotactic peptide-1, epidermal growth factor, macrophage colony stimulating factor, transforming growth factor-β1plays important role within process renal scaring and remodeling. Urinary tract infection causes expressed medullar renal scaring by toxins and inductive endogenic cytokines

Modernization of 10-year cardiovascular death risk scale SCORE

Ten-year cardiovascular death risk scale SCORE was modified, according to the results of 10-year retrospective population study in 270 families (1513 individuals examined). Among 73 registered deaths, 51 were due to cardiovascular disease. Additionally, quantitative assessment of hereditary cardiovascular risk was performed. In high genotypic risk group, myocardial infarction mortality was higher by 13 times than in low-risk group, stroke mortality - higher by 21.4 times. Scale modification helped to improve prognosis precision, by considering hereditary risk of cardiovascular pathology, that significantly affects mortality risk. Hereditary factors affected cardiovascular mortality more, as 10-year risk increased

Sulodexide. Nephroprotective properties and horizons for use in nephrology

Sulodexide belongs to the class of glycosaminoglycans (GAGs) or mucopolysaccharides. Found in mammalian tissuesm, GAGs regulate the activity of a wide range of proteins (including chemokines, cytokines, growth factors, enzymes, morphogens, and adhesion molecules). GAGs are large, linear, frequently sulfated, negatively charged polysaccharides with a molecular weight ranging 1-2,000 kDa. They are organized as repetitions of disaccharide units of an uronic acid (D-glucuronic acid or L-iduronic acid) and an acetylated amino sugar (N-acetylgalactosamine or N-acetylglucosamine) either sulfated or non-sulfated. [5] The position of sulfation of GAGs is widely variable depending on their cell and tissue localization. GAGs exist both as part of proteoglycans and as free chains. Non-sulfated GAGs include hyaluronic acid and sulfated GAGs include chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin, and heparan sulfate

Population and individual-level predicting of blood pressure

During regional population family survey, 1298 of Rostov-on-Don City and Region citizens were examined. Mean age was 42, 61 ± 0, 58 years. There were 527 men and 771 women; total number of families surveyed was 270. Correlation and regression analyses, as well as special population-level genetic analysis methods, were used. Prognostic models were developed in two- and multivariate regression analysis, with regression equation construction. Multiple regression equations, predicting systolic and diastolic blood pressure levels, could be used in medico-genetic counseling and population screening programs, to identify arterial hypertension high-risk groups