Rapid assembly of polycyclic structures via sigmatropic rearrangement of s-propargyl xanthates

International audienceUpon heating in chlorobenzene, propargyl xanthates yield the corresponding 4,5-bis(alkylidene)-1,3-dithiolan-2-ones which are trapped by unactivated olefins in an intramolecular Diels-Alder cycloaddition yielding interesting polycyclic structures

EU law and emotion data

This article sheds light on legal implications and challenges surrounding emotion data processing within the EU's legal framework. Despite the sensitive nature of emotion data, the GDPR does not categorize it as special data, resulting in a lack of comprehensive protection. The article also discusses the nuances of different approaches to affective computing and their relevance to the processing of special data under the GDPR. Moreover, it points to potential tensions with data protection principles, such as fairness and accuracy. Our article also highlights some of the consequences, including harm, that processing of emotion data may have for individuals concerned. Additionally, we discuss how the AI Act proposal intends to regulate affective computing. Finally, the article outlines the new obligations and transparency requirements introduced by the DSA for online platforms utilizing emotion data. Our article aims at raising awareness among the affective computing community about the applicable legal requirements when developing AC systems intended for the EU market, or when working with study participants located in the EU. We also stress the importance of protecting the fundamental rights of individuals even when the law struggles to keep up with technological developments that capture sensitive emotion data.Comment: 8 pages, 2023 11th International Conference on Affective Computing and Intelligent Interaction (ACII

Aging without disorder on long time scales

We study the Metropolis dynamics of a simple spin system without disorder, which exhibits glassy dynamics at low temperatures. We use an implementation of the algorithm of Bortz, Kalos and Lebowitz \cite{bortz}. This method turns out to be very efficient for the study of glassy systems, which get trapped in local minima on many different time scales. We find strong evidence of aging effects at low temperatures. We relate these effects to the distribution function of the trapping times of single configurations.Comment: 8 pages Revtex, 7 figures uuencoded (Revised version: the figures are now present

Generation of Alkyl Radicals:From the Tyranny of Tin to the Photon Democracy

Alkyl radicals are key intermediates in organic synthesis. Their classic generation from alkyl halides has a severe drawback due to the employment of toxic tin hydrides to the point that "flight from the tyranny of tin"in radical processes was considered for a long time an unavoidable issue. This review summarizes the main alternative approaches for the generation of unstabilized alkyl radicals, using photons as traceless promoters. The recent development in photochemical and photocatalyzed processes enabled the discovery of a plethora of new alkyl radical precursors, opening the world of radical chemistry to a broader community, thus allowing a new era of photon democracy

Reversal of diastereoselectivity in the synthesis of Peptidomimetic 3‑Carboxamide-1,4-benzodiazepin-5-ones

Enantiopure 3-carboxamide-1,4-benzodiazepin-5-ones were synthesized via the Ugi reaction followed by the Staudinger/aza-Wittig or reduction reactions in only two steps. A complete reversal of diastereoselectivity was achieved depending on the cyclization methodology employed. The different orientation of the C3 substituent in our 3-substituted 1,4-benzodiazepin-5-ones with respect to the most studied 1,4-benzodiazepin-2-ones makes them complementary in the development of new drugs because the primary source of binding selectivity of 1,4-benzodiazepines is the selective recognition of ligand conformations by the receptor.Ministerio de Economía y Competitividad, Spain (Project CTQ2012-31611), Junta de Castilla y León, Consejería de Educación y Cultura y Fondo Social Europeo (Project BU246A12-1) and the European Commission, Seventh Framework Programme (Project SNIFFER FP7-SEC-2012-312411)