Feeding interventions for growth and development in infants with cleft lip, cleft palate or cleft lip and palate.

BACKGROUND: Cleft lip and cleft palate are common birth defects, affecting about one baby of every 700 born. Feeding these babies is an immediate concern and there is evidence of delay in growth of children with a cleft as compared to those without clefting. In an effort to combat reduced weight for height, a variety of advice and devices are recommended to aid feeding of babies with clefts. OBJECTIVES: This review aims to assess the effects of these feeding interventions in babies with cleft lip and/or palate on growth, development and parental satisfaction. SEARCH STRATEGY: The following electronic databases were searched: the Cochrane Oral Health Group Trials Register (to 27 October 2010), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010, Issue 4), MEDLINE via OVID (1950 to 27 October 2010), EMBASE via OVID (1980 to 27 October 2010), PsycINFO via OVID (1950 to 27 October 2010) and CINAHL via EBSCO (1980 to 27 October 2010). Attempts were made to identify both unpublished and ongoing studies. There was no restriction with regard to language of publication. SELECTION CRITERIA: Studies were included if they were randomised controlled trials (RCTs) of feeding interventions for babies born with cleft lip, cleft palate or cleft lip and palate up to the age of 6 months (from term). DATA COLLECTION AND ANALYSIS: Studies were assessed for relevance independently and in duplicate. All studies meeting the inclusion criteria were data extracted and assessed for validity independently by each member of the review team. Authors were contacted for clarification or missing information whenever possible. MAIN RESULTS: Five RCTs with a total of 292 babies, were included in the review. Comparisons made within the RCTs were squeezable versus rigid feeding bottles (two studies), breastfeeding versus spoon-feeding (one study) and maxillary plate versus no plate (two studies). No statistically significant differences were shown for any of the primary outcomes when comparing bottle types, although squeezable bottles were less likely to require modification. No difference was shown for infants fitted with a maxillary plate compared to no plate. However, there was some evidence of an effect on weight at 6 weeks post-surgery in favour of breastfeeding when compared to spoon-feeding (mean difference 0.47; 95% confidence interval 0.20 to 0.74). AUTHORS' CONCLUSIONS: Squeezable bottles appear easier to use than rigid feeding bottles for babies born with clefts of the lip and/or palate, however, there is no evidence of a difference in growth outcomes between the bottle types. There is weak evidence that breastfeeding is better than spoon-feeding following surgery for cleft. There was no evidence to suggest that maxillary plates assist growth in babies with clefts of the palate. No evidence was found to assess the use of any types of maternal advice and/or support for these babies

New ⁴⁰Ar/³⁹Ar dating of the Grande Ronde lavas, Columbia River Basalts, USA: Implications for duration of flood basalt eruption episodes

Grande Ronde Basalt (GRB) lavas represent the most voluminous eruptive pulse of the Columbia River-Snake River-Yellowstone hotspot volcanism. With an estimated eruptive volume of 150,000 km3, GRB lavas form at least 66% of the total volume of the Columbia River Basalt Group. New 40Ar/39Ar dates for GRB lavas reveal they were emplaced within a maximum period of 0.42 ± 0.18 My. A well-documented stratigraphy indicates at least 110 GRB flow fields (or individual eruptions), and on this basis suggests an average inter-eruption hiatus of less than 4,000 years. Isotopic age-dating cannot resolve time gaps between GRB eruptions, and it is difficult to otherwise form a picture of the durations of eruptions because of non-uniform weathering in the top of flow fields and a general paucity of sediments between GR lavas. Where sediment has formed on top of the GRB, it varies in thickness from zero to 20-30 cm of silty to fine-sandy material, with occasional diatomaceous sediment. Individual GRB eruptions varied considerably in volume but many were greater than 1000 km3 in size. Most probably eruptive events were not equally spaced in time; some eruptions may have followed short periods of volcanic repose (perhaps 102 to 103 of yrs), whilst others could have been considerably longer (many 1000 s to > 104 yrs). Recent improvements in age-dating for other continental flood basalt (CFB) lava sequences have yielded estimates of total eruptive durations of less than 1 My for high-volume pulses of lava production. The GRB appears to be a similar example, where the main pulse occupied a brief period. Even allowing for moderate to long-duration pahoehoe flow field production, the amount of time the system spends in active lava-producing mode is small – less than c. 2.6% (based on eruption durations of approximately 10,000 yrs, as compared to the duration of the entire eruptive pulse of c. 420,000 yrs). A review of available 40Ar/39Ar data for the major voluminous phases of the Columbia River Basalt Group suggests that activity of the Steens Basalt-Imnaha Basalt-GRB may have, at times, been simultaneous, with obvious implications for climatic effects. Resolving intervals between successive eruptions during CFB province construction, and durations of main eruptive pulses, remains vital to determining the environmental impact of these huge eruptions

Kaluza-Klein Dark Matter, Electrons and Gamma Ray Telescopes

Kaluza-Klein dark matter particles can annihilate efficiently into electron-positron pairs, providing a discrete feature (a sharp edge) in the cosmic $e^+ e^-$ spectrum at an energy equal to the particle's mass (typically several hundred GeV to one TeV). Although this feature is probably beyond the reach of satellite or balloon-based cosmic ray experiments (those that distinguish the charge and mass of the primary particle), gamma ray telescopes may provide an alternative detection method. Designed to observe very high-energy gamma-rays, ACTs also observe the diffuse flux of electron-induced electromagnetic showers. The GLAST satellite, designed for gamma ray astronomy, will also observe any high energy showers (several hundred GeV and above) in its calorimeter. We show that high-significance detections of an electron-positron feature from Kaluza-Klein dark matter annihilations are possible with GLAST, and also with ACTs such as HESS, VERITAS or MAGIC.Comment: 10 pages, 2 figure

Two photon annihilation of Kaluza-Klein dark matter

We investigate the fermionic one-loop cross section for the two photon annihilation of Kaluza-Klein (KK) dark matter particles in a model of universal extra dimensions (UED). This process gives a nearly mono-energetic gamma-ray line with energy equal to the KK dark matter particle mass. We find that the cross section is large enough that if a continuum signature is detected, the energy distribution of gamma-rays should end at the particle mass with a peak that is visible for an energy resolution of the detector at the percent level. This would give an unmistakable signature of a dark matter origin of the gamma-rays, and a unique determination of the dark matter particle mass, which in the case studied should be around 800 GeV. Unlike the situation for supersymmetric models where the two-gamma peak may or may not be visible depending on parameters, this feature seems to be quite robust in UED models, and should be similar in other models where annihilation into fermions is not helicity suppressed. The observability of the signal still depends on largely unknown astrophysical parameters related to the structure of the dark matter halo. If the dark matter near the galactic center is adiabatically contracted by the central star cluster, or if the dark matter halo has substructure surviving tidal effects, prospects for detection look promising.Comment: 17 pages, 3 figures; slightly revised versio

Plasma Physics

Contains reports on three research projects.U. S. Atomic Energy Commission (Contract AT(30- 1)- 1842

Identifying experiences of supportive care of children and young people affected by kidney failure: a qualitative systematic review.

Children and young people affected by kidney failure experience complexities in their care. Little is known about the unique needs of this young patient population group living with a long-term condition. A meta-aggregation of all qualitative studies was conducted to identify experiences of supportive care among children and young people living with kidney failure. A systematic review of qualitative studies was conducted following the Joanna Briggs Institute meta-aggregation method. This review has been reported according to the PRISMA statement guidelines. Six electronic databases (CINAHL, Cochrane Library, MEDLINE, Proquest, PsycINFO, and Scopus) were comprehensively searched by an expert systematic review librarian using keywords and subject headings, from inception to September 2022. All studies were accessed using a predetermined inclusion and exclusion criteria. Methodological quality assessment and data extraction performed. Qualitative findings accompanied by illustrative quotes from included studies were extracted and grouped into categories which created the overall synthesised findings. A total of 34 studies were included in this review representing a total of 613 children and young people affected by kidney failure. There was a total of 190 findings which created 13 categories representing experiences of supportive care. The meta-aggregation developed five synthesised findings namely: 'physical needs', 'information and technology', 'treatment and healthcare', 'social needs' and 'psychological impacts'. This systematic review identified that children and young people affected by kidney failure can experience a range of unmet supportive care needs in routine clinical services. Kidney failure impacted children and young people's self-identify, social and peer networks, introduced daily practical needs because of inherent physical and psychological burden due to the failure and associated treatments. Despite improvements in the medical management of kidney failure in children and young people, further attention is needed to optimise supported self-management in this young patient group

Food Insecurity and Eating Disorders: A Review of Emerging Evidence

Purpose of Review: This review summarizes emerging evidence for the relationship between food insecurity and eating disorder (ED) pathology, outlines priorities for future research in this area, and comments on considerations for clinical and public health practice. Recent Findings: Among adults, food insecurity is cross-sectionally associated with higher levels of overall ED pathology, binge eating, compensatory behaviors, binge-eating disorder, and bulimia nervosa. Evidence for similar relationships among adolescents has been less robust; however, compared to studies of adults, there have been substantially fewer studies conducted in adolescents to date. Summary: Emerging evidence consistently indicates that food insecurity is cross-sectionally associated with bulimic-spectrum ED pathology among adults. Findings emphasize the need for ED research to include marginalized populations who have historically been overlooked in the ED field. Much more research is needed to better understand the relationship between food insecurity and ED pathology and to determine effective ways to intervene