Towards a characterization of behavior-disease models

The last decade saw the advent of increasingly realistic epidemic models that leverage on the availability of highly detailed census and human mobility data. Data-driven models aim at a granularity down to the level of households or single individuals. However, relatively little systematic work has been done to provide coupled behavior-disease models able to close the feedback loop between behavioral changes triggered in the population by an individual's perception of the disease spread and the actual disease spread itself. While models lacking this coupling can be extremely successful in mild epidemics, they obviously will be of limited use in situations where social disruption or behavioral alterations are induced in the population by knowledge of the disease. Here we propose a characterization of a set of prototypical mechanisms for self-initiated social distancing induced by local and non-local prevalence-based information available to individuals in the population. We characterize the effects of these mechanisms in the framework of a compartmental scheme that enlarges the basic SIR model by considering separate behavioral classes within the population. The transition of individuals in/out of behavioral classes is coupled with the spreading of the disease and provides a rich phase space with multiple epidemic peaks and tipping points. The class of models presented here can be used in the case of data-driven computational approaches to analyze scenarios of social adaptation and behavioral change.Comment: 24 pages, 15 figure

Laser ablation depth profiling of U-series and Sr isotopes in human fossils

We have explored laser depth profiling to obtain data sets for U-series as well as Sr analyses. Laser probing with an 81 μm spot size allows for the exploration of low uranium domains of up to 400 μm below the outer surface in tooth enamel. These low U domains will contain Sr isotope compositions of the individual, that are least affected by diagenetic Sr overprints. The small holes drilled for U surveying are not visible to the naked eye. Using larger spot sizes of around 233 μm, laser drilling can be used to obtain reliable U-series isotope data to a depth of approximately 1000 μm in enamel and around 1300 μm in bone. Furthermore, meaningful 87Sr/86Sr isotope data can also be obtained with this spot size. Using our sampling strategy, the overall damage to a human tooth is minute, as demonstrated on a Neanderthal tooth from Moula-Guercy. We expect that laser ablation depth profiling will become routine for gaining insights into the age of human fossils and the migrations of ancient humans

Moclobemide (ro-11-1163) Vs Clomipramine in the Treatment of Depression - a Double-blind Multicenter Study in Belgium

A multicenter study to compare the antidepressant efficacy and the tolerance of moclobemide (Ro 11-1163) to clomipramine was performed in parallel groups of patients with minor depression. The duration of the study was 6 weeks, with weekly assessments by means of Hamilton Scale of Depression (HRDS) and the Clinical Global Impression (CGI). The efficacy of moclobemide was found to be as good as that of clomipramine. The results for tolerability were possibly in favor of moclobemide. It was recommended that consumption of tyramine-containing foods be kept to a minimum or avoided and no hypertensive crises were reported