One pot synthesis of 3-(1<i>H</i>-imidazo[4,5-<i>f</i>]quinolin-2-yl)-chromen-2-one under microwave irradiation

417-419Rapid and efficient method for the synthesis of imidazoquinolinyl- chromen-2-ones under microwave (MW) irradiation is described. A comparative study of conventional and MW methods is briefly discussed

Synthesis of biologically active angularly fused bisaroylbenzodifurans by PTC and solvent free microwave irradiation

425-428Angularly fused bisaroylbenzodifurans 3a-f have been synthesized by condensing 2,4-diacetyl resorcinol 1 with various p-substituted phenacyl bromides 2a-f under (a) phase transfer catalysis method and (b) microwave irradiation method. A comparison has been made between the two methods. Microwave irradiation has been found to be an efficient route for the synthesis of angularly fused bisaroylbenzodifurans. All the compounds 3a-f have been screened for anti-bacterial activity. The benzodifurans 3c and 3f have shown excellent activity against gram-positive (Staphylococcus aureus) bacteria at both 600 and 900 μg/mL and the compound 3b and 3d are found active at 900 μg/mL on the same bacteia. The bisaroylbenzodifurans 3a-f have also been screened for anti-fungal activity. The compounds 3c, 3d and 3f have shown maximum spore germination inhibition on Drechslera halodes fungi and the compounds 3a, 3b, 3c, 3d, and 3f have shown maximum spore germination inhibition on Fusarium oxysporum fungi at 960μg/mL. The bisaroylbenzodifurans 3a and 3e have been screened for anti-implantation activity as well and found to be inactive at 10 mg/kg/rat/day

Synthesis of 2, 3-diphenyl-5-methyl-6-aroylbenzo[1,2-<i>b</i>:5,4-<i>b</i>']difurans under PTC conditions and their anti-microbial activity

479-4832, 3-Diphenyl-6-hydroxybenzofuran 1 and 2, 3-diphenyl-5-acetyl-6-hydroxybenzofuran 3 have been synthesized under microwave irradiation. 2,3-Diphenyl-5-acetyl-6-aroylbenzo[1 ,2-b:5,4-b']difurans 5a-h and 6a-e have been synthesized from the reaction of 3 and phenacyl bromides 4a-h under PTC conditions using TBAHS4 (Tetrabutylammonium hydrogen sulphate) as a catalyst in good yields. The compounds 5a-h and 6a-e have been screened for antibacterial and antifungal activities. Compounds 5b and 5e have shown maximum inhibitory activity against E. coli and S. aureus, while compounds 5b, 5e-g and 6a show maximum spore germination inhibition against Fusarium moniforme

Design and synthesis of aroylbenzodifurans as anti-implantation agents

938-941<span style="font-size:12.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-in;mso-fareast-language:en-in;mso-bidi-language:ar-sa"="" lang="EN-IN">Bisaroylbenzodifurans namely, 3, 5-dimethyl-2, 6-dibenzoyl-(3a); 2, 6-di(4-methylbenzoyl)-(3b); 2, 6-di(4-chlorobenzoyl-(3c); 2,6-di(4-bromobenzoyl)-(3d); 2, 6-di-(4-nitrobenzoyl)-(3e); 2, 6-di-(4-phenylbenzoyI)-(3f) and 2, 6-di-(4- methoxybenzoyl)-(3g)-benzo[1,2-<i style="mso-bidi-font-style: normal">b: 5,4-b'] difurans have been synthesized by condensing resdiacetophenone with phenacyl bromide in (a) baked K2CO3,-dry acetone and (b) under phase transfer catalytic conditions. A comparison has been made between the two methods. PTC procedure is observed as an effective route for the synthesis of bisaroyl benzodifurans. All the seven compounds are screened for anti-implantation activity. 3a is found to be active in preventing implantation in albino rats at 2 mg/kg/rat/day.</span