Genodermatoses (Inherited Diseases with Cutaneous Manifestations): Molecular Biology and Diagnosis

Genodermatoses are a variable group of inherited diseases that initially, or at least very early in life, present with cutaneous findings. They include divergent diseases, which could be divided into, for instance, disorders of pigmentation (example - albinism); disorders of keratinization (example - congenitalichthyosi form erythroderma), etc. The focus of this article is a subset of genodermatoses that are associated with increased risk of various skin neoplasms that develop either very early or later in life. Thus, this subset has often been dubbed as "inherited or heritable cancer syndromes". However, it is important to realize that not all of inherited cancer syndromes have protean skin manifestations, and that indeed, not all of the genodermatoses have neoplastic associations. The particular diseases this article deals with are Muir-Torre syndrome, Cowden\u27s disease, and Carney\u27s complex

Momentum distribution of a freely expanding Lieb-Liniger gas

We numerically study free expansion of a few Lieb-Liniger bosons, which are initially in the ground state of an infinitely deep hard-wall trap. Numerical calculation is carried out by employing a standard Fourier transform, as follows from the Fermi-Bose transformation for a time-dependent Lieb-Liniger gas. We study the evolution of the momentum distribution, the real-space single-particle density, and the occupancies of natural orbitals. Our numerical calculation allows us to explore the behavior of these observables in the transient regime of the expansion, where they are non-trivially affected by the particle interactions. We derive analytically (by using the stationary phase approximation) the formula which connects the asymptotic shape of the momentum distribution and the initial state. For sufficiently large times the momentum distribution coincides (up to a simple scaling transformation) with the shape of the real-space single-particle density (the expansion is asymptotically ballistic). Our analytical and numerical results are in good agreement.Comment: small changes; references correcte

Anderson localization of a Tonks-Girardeau gas in potentials with controlled disorder

We theoretically demonstrate features of Anderson localization in the Tonks-Girardeau gas confined in one-dimensional (1D) potentials with controlled disorder. That is, we investigate the evolution of the single particle density and correlations of a Tonks-Girardeau wave packet in such disordered potentials. The wave packet is initially trapped, the trap is suddenly turned off, and after some time the system evolves into a localized steady state due to Anderson localization. The density tails of the steady state decay exponentially, while the coherence in these tails increases. The latter phenomenon corresponds to the same effect found in incoherent optical solitons

The Comparison of Forensic-Psychiatric Traits between Female and Male Perpetrators of Murder or Attempted Murder

The aim of this investigation was to define more clearly specific forensic-psychiatric characteristics of female murder or attempted murder perpetrators. The retrospective method applied was based on the comparison of the data from forensic-psychiatric assessments carried out in the Center for Forensic Psychiatry, Psychiatric Hospital Vrapče, Zagreb, from 1983 to 1997 (including 70 female and 70 male subjects – who committed murder or attempted murder). Compared with men, female offenders were most often in some way emotionally related to their victims, and they were more often victimized themselves before committing the crime. In men alcoholism was a more significant circumstantial factor in the assessment of their accountability. Psychiatric security measures were more often given to male offenders. The intensity of aggression was lower in females than in males. This investigation reveals that there are some sex specific forensic-psychiatric traits of murder or attempted murder perpetrators. The obtained results could be of help in everyday forensic-psychiatric practice, both in assessments and treatment

Bewertung der bei Basketballeuropameisterschaft in Barcelona1997 verzeichneten variablen des Schießens aufs ziel

The research was conducted in order to determine the size of the influence that the variables regarding throwing the ball into the basket have on the final basketball match score. For data acquisition the sample of 62 European Championship matches held in Barcelona was used. The sample of manifested variables consisted of seven standard indicators of situation related efficiency concerning shooting and assists that were officially registered for each team. The data, gathered from the official basketball] game statistics, were processed by means of basic statistical procedures, while the main research problem was analyzed by applying the classical algorithm of the regression analysis. The significant difference was determined between the winning and losing teams in variables of shooting and assists, the winning teams achieving the better results. The difference in the total match score averages between the winning and losing teams was 11 points. Regression analysis revealed interesting information on the relation of the predicting variables regarding ball throws and assists with the final game score in a basketball match. Multiple and partial regression coefficients suggest that the final match score could be predicted on the basis of the predicting variables. Multiple correlation of .59 is statistically significant and there is no doubt that 35% of the variance is common to the predicting variables and to the final match score. In the partial regression coefficients three variables (SUT2NE - two-point field goal-unsuccessful, SUT3NE - three-point field goal unsuccessful, and SLBAUS- free throws-successful) appeared to be the significant predictors. The obtained results support the tactical requirements for a high quality of the play organization on the phase of offence, which should provide a rational selection of shootings and minimize the number of unsuccessful throws. The SLBAUS variable displays that the losing teams were repeatedly forced to commit a considerable number of personal fouls which was, from the aspect of the success criterion, i.e. the final match outcome, beneficial for the winning teams that were successful in performing free throws. This study is a continuation of the research, established long ago, on the influence of standard indicators of the situation-related efficiency on a match outcome or success in the basketball game. It opens further possibilities for enlarging the basis of knowledge concerning this important segment of exact, objective monitoring of sports games, especially basketball.Das Ziel der Untersuchung war, den Einflussausmaß der die Korbeinwürfe betreffenden Variablen auf das Endresultat eines Basketballspieles festzustellen. Die Daten wurden aus 62 Spielen der Europameisterschaft in Barcelona abgenommen. Das Variablenmuster umfasste 7 gewöhnliche Anzeigen der situationsbezogenen Effizienz bezüglich Einwürfe und Assistenzen, die für jede Mannschaft offiziel verzeichnet wurden. Die aus der offizielen Spielstatistik erworbenen Daten wurden mittels statistischer Grundverfahren bearbeitet, während das Hauptproblem durch den klassischen Algorithmus der Regressionsanalyse analysiert wurde. Ein statistisch bedeutender Unterschied zwischen den erfolgreichen und den verlierenden Mannschaften wurde in den Variablen der Einwürfe und der Assistenzen zugunsten des Gewinners festgestellt. Der durchschnittliche Endergebnisunterschied zwischen den Gewinnern und den Verlierern war 11 Punkte. Mittels der Regressionsanalyse wurden interessante Informationen über die Beziehung der Prädiktorvariablen des Ballwurfs und der Assistenzen mit dem Endergebnis des Spieles entdeckt. Multiple und partiale Regressionskoeffiziente zeigen, dass das Endergebnis aufgrund der Prädiktorvariablen vorausgesehen werden kann. Die multiple Korrelation von 0,59 ist statistisch bedeutend und zweifellos ist 35% der Varianz den Prädiktorvariablen und dem Endergebnis gemeinsam. Unter den partialen Regressionskoeffizienten schienen 3 Variablen als bedeutende Anzeigen (SUT2NE — unerfolgreicher 2-Punkte-Schuß, SUT3NE- unerforlgreicher 3-Punkte-Schuß und SLBAUS - erfolgreicher Freiwurf). Die erworbenen Ergebnisse unterstützen den taktischen Bedarf nach guter Spielorganisation in der Verteidigungsphase, um eine rationale Ballwurfselektion zu ermöglichen und damit die Zahl unerfolgreicher Ballwürfe zu vermindern. Die Variable “SLBAUS” zeigt, dass die verlierende Mannschaft immer wieder dazu gezwungen war, mehrere Personalfouls zu machen, was vom Erfolgsamkeitsaspekt (Endresultat) für die in den Freischüssen erfolgreiche Gewinnermannschaft günstig war. Diese Studie ist die Fortsetzung einer vor langer Zeit durchgeführten Untersuchung über den Einfluss der Standardanzeigen der situationsbezogenen Effizienz auf das Endresultat oder die Leistung in einem Basketballspiel. Sie gibt weitere Möglichkeiten, um die Kenntnisbasis in diesem wichtigen Segment der exakten und objektiven Beobachtung der Ballspiele, besonders Basketballs, zu erweitern

Bewertung der bei Basketballeuropameisterschaft in Barcelona1997 verzeichneten variablen des Schießens aufs ziel

The research was conducted in order to determine the size of the influence that the variables regarding throwing the ball into the basket have on the final basketball match score. For data acquisition the sample of 62 European Championship matches held in Barcelona was used. The sample of manifested variables consisted of seven standard indicators of situation related efficiency concerning shooting and assists that were officially registered for each team. The data, gathered from the official basketball] game statistics, were processed by means of basic statistical procedures, while the main research problem was analyzed by applying the classical algorithm of the regression analysis. The significant difference was determined between the winning and losing teams in variables of shooting and assists, the winning teams achieving the better results. The difference in the total match score averages between the winning and losing teams was 11 points. Regression analysis revealed interesting information on the relation of the predicting variables regarding ball throws and assists with the final game score in a basketball match. Multiple and partial regression coefficients suggest that the final match score could be predicted on the basis of the predicting variables. Multiple correlation of .59 is statistically significant and there is no doubt that 35% of the variance is common to the predicting variables and to the final match score. In the partial regression coefficients three variables (SUT2NE - two-point field goal-unsuccessful, SUT3NE - three-point field goal unsuccessful, and SLBAUS- free throws-successful) appeared to be the significant predictors. The obtained results support the tactical requirements for a high quality of the play organization on the phase of offence, which should provide a rational selection of shootings and minimize the number of unsuccessful throws. The SLBAUS variable displays that the losing teams were repeatedly forced to commit a considerable number of personal fouls which was, from the aspect of the success criterion, i.e. the final match outcome, beneficial for the winning teams that were successful in performing free throws. This study is a continuation of the research, established long ago, on the influence of standard indicators of the situation-related efficiency on a match outcome or success in the basketball game. It opens further possibilities for enlarging the basis of knowledge concerning this important segment of exact, objective monitoring of sports games, especially basketball.Das Ziel der Untersuchung war, den Einflussausmaß der die Korbeinwürfe betreffenden Variablen auf das Endresultat eines Basketballspieles festzustellen. Die Daten wurden aus 62 Spielen der Europameisterschaft in Barcelona abgenommen. Das Variablenmuster umfasste 7 gewöhnliche Anzeigen der situationsbezogenen Effizienz bezüglich Einwürfe und Assistenzen, die für jede Mannschaft offiziel verzeichnet wurden. Die aus der offizielen Spielstatistik erworbenen Daten wurden mittels statistischer Grundverfahren bearbeitet, während das Hauptproblem durch den klassischen Algorithmus der Regressionsanalyse analysiert wurde. Ein statistisch bedeutender Unterschied zwischen den erfolgreichen und den verlierenden Mannschaften wurde in den Variablen der Einwürfe und der Assistenzen zugunsten des Gewinners festgestellt. Der durchschnittliche Endergebnisunterschied zwischen den Gewinnern und den Verlierern war 11 Punkte. Mittels der Regressionsanalyse wurden interessante Informationen über die Beziehung der Prädiktorvariablen des Ballwurfs und der Assistenzen mit dem Endergebnis des Spieles entdeckt. Multiple und partiale Regressionskoeffiziente zeigen, dass das Endergebnis aufgrund der Prädiktorvariablen vorausgesehen werden kann. Die multiple Korrelation von 0,59 ist statistisch bedeutend und zweifellos ist 35% der Varianz den Prädiktorvariablen und dem Endergebnis gemeinsam. Unter den partialen Regressionskoeffizienten schienen 3 Variablen als bedeutende Anzeigen (SUT2NE — unerfolgreicher 2-Punkte-Schuß, SUT3NE- unerforlgreicher 3-Punkte-Schuß und SLBAUS - erfolgreicher Freiwurf). Die erworbenen Ergebnisse unterstützen den taktischen Bedarf nach guter Spielorganisation in der Verteidigungsphase, um eine rationale Ballwurfselektion zu ermöglichen und damit die Zahl unerfolgreicher Ballwürfe zu vermindern. Die Variable “SLBAUS” zeigt, dass die verlierende Mannschaft immer wieder dazu gezwungen war, mehrere Personalfouls zu machen, was vom Erfolgsamkeitsaspekt (Endresultat) für die in den Freischüssen erfolgreiche Gewinnermannschaft günstig war. Diese Studie ist die Fortsetzung einer vor langer Zeit durchgeführten Untersuchung über den Einfluss der Standardanzeigen der situationsbezogenen Effizienz auf das Endresultat oder die Leistung in einem Basketballspiel. Sie gibt weitere Möglichkeiten, um die Kenntnisbasis in diesem wichtigen Segment der exakten und objektiven Beobachtung der Ballspiele, besonders Basketballs, zu erweitern

Effect of apple by-product as a supplement on antioxidant activity and quality parameters of pasta

In this study, pasta was prepared by replacement of durum semolina (DS) with 10% and 15% of apple peel powder (APP). The control sample was pasta made from 100% DS. Total phenolic content (TPC), antioxidant capacity (AOA) and quality parameters of pasta were determined before and after cooking. Extraction of phenolics with methanol and ethanol, assisted with ultrasound (15 min) and by stirring (with magnetic stirrer for 1 h) was also compared. Results showed that addition of APP increased cooking loss and the amount of absorbed water of the pasta samples. Hardness and adhesiveness of pasta samples was decreased with APP addition. Pasta with added APP had significant higher levels of TPC and AOA compared with pasta without addition of APP. The highest TPC (1.4 g of gallic acid equivalents/kg) was in raw pasta with addition of 15% APP from which phenolics were extracted with ultrasound assisted extraction and methanol. Regarding AOA, the highest antioxidant activity (0.8 mg gallic acid equivalents/100g) was also in raw pasta with 15% APP, from which phenolics were extracted by stirring and ethanol. In cooked pasta, the levels of TPC and AOA, were significantly lower compared to raw pasta (p≤0.05). Sensory evaluation showed that there was no significant difference between DS and DS + 10% APP. Apple peel powder (APP) could be a food by-product, conveniently used as additive, for delivering health-promoting bioactive compounds such as polyphenols